2022 Articles
Single dose and chronic oral administration of cannabigerol and cannabigerolic acid-rich hemp extract in fed and fasted dogs: Physiological effect and pharmacokinetic evaluation.
Amstutz K, Schwark WS, Zakharov A, Gomez B, Lyubimov A, Ellis K, Venator ZP, Wakshlag JJ.
J. Vet. Pharmacol. Ther., 2022, 45, 245-254.
Abstract
Effect of Chaihu Shugan pills on the pharmacokinetics of duloxetine and its metabolite 4-hydroxyduloxetine in beagle dogs: A herb-drug interaction study.
Bi YT, Kang YR, Woshur G, Ding HZ, Wang SS, Qiu XJ.
Evid. Based Complement. Alternat. Med., 2022, 2022, 2350560.
Abstract
Metabolites identification and species comparison of Oroxylin A, an anti-cancer flavonoid, in vitro and in vivo by HPLC-Q-TOF-MS/MS.
Bian Y, Sun M, Chen H, Ren G, Fu K, Yang N, Zhang M, Zhou N, Lu Y, Li N, Zhang Y, Chen X, Zhao D.
Xenobiotica, 2022, 52, 165-176.
Abstract
Case report: Synephrine, a plant substance yielding classic environmental clusters of hay related identifications in equine urine.
Brewer K,Machin JJ, Maylin G, Fenger C, Morales-Briceño A,Neidhart MM, Tobin T.
Drug Test. Anal., 2022, 14, 774-780.
Abstract
Gabapentin, a human therapeutic medication and an environmental substance transferring at trace levels to horses: a case report.
Brewer K, Machin J, Maylin G, Fenger C, Morales-Briceño A, Tobin T.
Ir. Vet. J., 2022, 75, 19.
Abstract
Biomarker ratios.
Cawley A, Keen B, Tou K, Elbourne M, Keledjian J.
Drug Test. Anal., 2022, 14, 983-990.
Abstract
Pharmacokinetic exposures associated with oral administration of sorafenib in dogs with spontaneous tumors.
Cawley JR, Stewart SD, Mochel JP, Veluvolu S, Khanna C, Fenger JM.
Front. Vet. Sci., 2022, 9, 888483.
Abstract
Optimization and implementation of four duplex quantitative polymerase chain reaction assays for gene doping control in horseracing.
Cheung HW, Wong KS, Lin VYC, Farrington AF, Bond A, Wan TSM, Ho ENM.
Drug Test. Anal., 2022, 14, 1587-1598.
Abstract
Novel dapagliflozin di-L-proline cocrystal-loaded tablet: Preparation, physicochemical characterization, and pharmacokinetics in beagle dogs and mini-pigs.
Cho HJ, Woo MR, Cho JH, Kim YI, Choi HG.
Pharm. Dev. Technol., 2022, 27, 331-340.
Abstract
From a non-targeted metabolomics approach to a targeted biomarkers strategy to highlight testosterone abuse in equine. Illustration of a methodological transfer between platforms and laboratories.
Cloteau C, Dervilly G, Kaabia Z, Bagilet F, Delcourt V, Loup B, Guitton Y, Royer AL, Monteau F, Garcia P, Ma P, Le Bizec B, Bailly-Chouriberry L.
Drug Test. Anal., 2022, 14, 864-878.
Abstract
Equine metabolism of the growth hormone secretagogue MK-0677 in vitro and in urine and plasma following oral administration.
Cutler C, Viljanto M, Taylor P, Habershon-Butcher J, Van Eenoo P.
Drug Test. Anal., 2022, 14, 1273-1290.
Abstract
Identification of equine in vitro metabolites of seven non-steroidal selective androgen receptor modulators for doping control purposes.
Cutler C, Viljanto M, Taylor P, Hincks P, Biddle S, Van Eenoo P.
Drug Test. Anal., 2022, 14, 349-370.
Abstract
In vitro metabolism of the REV-ERB agonist SR-9009 and subsequent detection of metabolites in associated routine equine plasma and urine doping control samples.
Cutler C, White D, Viljanto M.
Drug Test. Anal., 2022, 14, 169-174.
Abstract
Absorption, distribution, metabolism and excretion of [14C]-sotorasib in rats and dogs: Interspecies differences in absorption, protein conjugation and metabolism.
Dahal UP, Rock BM, Rodgers J, Shen X, Wang Z, Wahlstrom JL.
Drug Metab. Dispos., 2022, 50, 600-612.
Abstract
Preclinical drug pharmacokinetic, tissue distribution and excretion profiles of the novel limonin derivate HY-071085 as an anti-inflammatory and analgesic candidate in rats and beagle dogs.
Dong L, Liu W, Zhao X, Yu F, Xu Y, Su M.
Pharmaceuticals (Basel), 2022, 15, 801.
Abstract
Intelligence benefit of the 3-methoxytyramine to tyramine ratio in equine urine.
Elbourne M, Cawley A, Stanley S, Bowen C, Fu S.
Drug Test. Anal., 2022, 14, 936-942.
Abstract
Pharmacokinetics of intravenous, oral transmucosal, and intranasal buprenorphine in healthy male dogs.
Enomoto H, Love L, Madsen M, Wallace A, Messenger KM.
J. Vet. Pharmacol. Ther., 2022, 45, 358-365.
Abstract
Lithium concentration in biological samples and gender difference in athletic horses.
Fazio F, Aragona F, Piccione G, Arfuso F, Giannetto C.
J. Equine Vet. Sci., 2022, 117, 104081.
Abstract
Simultaneous quantification of caffeine and its main metabolites by gas chromatography mass spectrometry in horse urine.
Göktaş EF, Kabil E, Yatanaslan L, Güneş E, Dirikolu L.
Biomed. Chromatogr., 2022, 36, e5445.
Abstract
In vitro and in vivo metabolism of the anabolic-androgenic steroid oxandrolone in the horse.
Harding C, Viljanto M, Cutler C, Habershon-Butcher J, Biddle S, Scarth J.
Drug Test. Anal., 2022, 14, 39-55.
Abstract
Pharmacokinetics of glaucine after intravenous and oral administrations and detection of systemic aporphine alkaloids after ingestion of tulip poplar shavings in horses.
Haughan JE, Missanelli JR, You Y, Stefanovski D, Soma LR, Robinson MA.
J. Vet. Pharmacol. Ther., 2022, 45, 273-282.
Abstract
Pharmacokinetics of grapiprant and effects on TNF-alpha concentrations following oral administration to horses.
Hoffmann SL, Seminoff K, McKemie DS, Kass PH, Knych HK.
J. Vet. Pharmacol. Ther., 2022, 45, 467-472.
Abstract
Pharmacokinetics of a single dose of oclacitinib maleate as a top dress in adult horses.
Hunyadi L, Datta P, Rewers-Felkins K, Sundman E, Hale T, Fajt V, Wagner S.
J. Vet. Pharmacol. Ther., 2022, 45, 320-324.
Abstract
Comprehensive metabolic study of nicotine in equine plasma and urine using liquid chromatography/high-resolution mass spectrometry for the identification of unique biomarkers for doping control.
Ishii H, Leung GN, Yamashita S, Nagata SI, Kushiro A, Sakai S, Toju K, Okada J, Kawasaki K, Kusano K, Kijima-Suda I.
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 2022, 1190, 123100.
Abstract
Identification of potential biomarkers in urine and plasma after consumption of tobacco product in horses.
Ishii H, Leung GN, Yamashita S, Nagata SI, Kushiro A, Sakai S, Toju K, Okada J, Kawasaki K, Kusano K, Kijima-Suda I.
Drug Test. Anal., 2022, 14, 902-914.
Abstract
Generic approach for the discovery of drug metabolites in horses based on data-dependent acquisition by liquid chromatography high-resolution mass spectrometry and its applications to pharmacokinetic study of daprodustat.
Ishii H, Shibuya M, Kusano K, Sone Y, Kamiya T, Wakuno A, Ito H, Miyata K, Sato F, Kuroda T, Yamada M, Leung GN.
Anal. Bioanal. Chem., 2022, 414, 8125-8142.
Abstract
Pharmacokinetic study of vadadustat and high-resolution mass spectrometric characterization of its novel metabolites in equines for the purpose of doping control.
Ishii H, Shibuya M, Kusano K, Sone Y, Kamiya T, Wakuno A, Ito H, Miyata K, Sato F, Kuroda T, Yamada M, Leung GN.
Curr. Drug Metab., 2022, 23, 850-865.
Abstract
Additional studies on nicotine exposure in horses: Accurate quantification and elimination profiles of potential biomarkers in plasma and urine.
Ishii H, Shibuya M, Leung GN, Yamashita S, Nagata SI, Kushiro A, Sakai S, Toju K, Okada J, Kawasaki K, Kusano K, Kijima-Suda I.
Rapid Commun. Mass Spectrom., 2022, 36, e9396.
Abstract
Comprehensive metabolic study of IOX4 in equine urine and plasma using liquid chromatography/electrospray ionization Q Exactive high-resolution mass spectrometer for the purpose of doping control.
Ishii H, Shibuya M, So YM, Wong JKY, Ho ENM, Kusano K, Sone Y, Kamiya T, Wakuno A, Ito H, Miyata K, Yamada M, Leung GN.
Drug Test. Anal., 2022, 14, 233-251.
Abstract
Long-term monitoring of IOX4 in horse hair and its longitudinal distribution with segmental analysis using liquid chromatography/electrospray ionization Q Exactive high-resolution mass spectrometry for the purpose of doping control.
Ishii H, Shibuya M, So YM, Wong JKY, Ho ENM, Kusano K, Sone Y, Kamiya T, Wakuno A, Ito H, Miyata K, Yamada M, Leung GN.
Drug. Test. Anal., 2022, 14, 1244-1254.
Abstract
Gene transcripts expressed in equine white blood cells are potential biomarkers of extracorporeal shock wave therapy.
Jiang Z, Chen JW, Haughan J, Stefanovski D, Soma LR, Robinson MA.
Drug Test. Anal., 2022, 14, 973-982.
Abstract
A quantitative PCR screening method for adeno-associated viral vector 2-mediated gene doping.
Jiang Z, Haughan J, Moss KL, Stefanovski D, Ortved KF, Robinson MA.
Drug Test. Anal., 2022, 14, 963-972.
Abstract
Bioanalysis of lanreotide in dog plasma using liquid chromatography-tandem mass spectrometry and its application in a pharmacokinetic study of beagle dogs after single subcutaneous injection.
Kim T, Choi S, Lim DS, Yun HY.
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 2022, 1188, 123078.
Abstract
Detection and residence time of bisphosphonates in bone of horses.
Knych HK, Janes J, Kennedy L, McKemie DS, Arthur RM, Samol MA, Uzal FA, Scollay M.
J. Vet. Diagn. Invest., 2022, 34, 23-27.
Abstract
Characterization of the pharmacokinetics, behavioral effects and effects on thermal nociception of morphine 6-glucuronide and morphine 3-glucuronide in horses.
Knych HK, Kanarr K, Fang Y, McKemie DS, Kass PH.
Vet. Anaesth. Analg., 2022, 49, 634-644.
Abstract
Medication control of flunixin in racing horses: possible detection times using Monte Carlo simulations.
Kuroda T, Minamijima Y, Nomura M, Yamashita S, Yamada M, Nagata S, Mita H, Tamura N, Fukuda K, Kuwano A, Kusano K, Toutain PL, Sato F.
Equine Vet. J., 2022, 54, 979-988.
Abstract
Study of cobalt doping control via various routes in thoroughbred horses.
Kwak YB, Yu J, Im EJ, Jeong BS, Yoo HH.
Drug Test. Anal., 2022, 14, 718-723.
Abstract
A quantitative method for the simultaneous detection of SR9009 and SR9011 in equine plasma using liquid chromatography-electrospray ionization-tandem mass spectrometry.
Kwak YB, Yu J, Yoo HH.
Drug Test. Anal., 2022, 14, 1532-1538.
Abstract
Intravenous magnesium sulphate in standing horses: effects on physiological parameters, plasma concentration of magnesium and nociceptive threshold tests.
La Rosa L, Twele L, Duchateau L, Gasthuys F, Kästner SB, Schauvliege S.
J. Equine Vet. Sci., 2022, 118, 104103.
Abstract
Enantiospecific pharmacokinetics of intravenous dexmedetomidine in beagles.
Levionnois OL, Barbarossa A, Bardhi A, Siegenthaler J, Forss Pleyers T, Guidi M, Spadavecchia C, Raillard M.
J. Vet. Pharmacol. Ther., 2022, 45, 366-372.
Abstract
miRNAs detection in equine plasma by quantitative polymerase chain reaction for doping control: Assessment of blood sampling and study of eca-miR-144 as potential erythropoiesis stimulating agent biomarker.
Loup B, André F, Avignon J, Lhuaire M, Delcourt V, Barnabé A, Garcia P, Popot MA, Bailly-Chouriberry L.
Drug Test. Anal., 2022, 14, 953-962.
Abstract
Pharmacokinetics and pharmacodynamics of oral and intravenous metoprolol tartrate in clinically healthy horses.
Luethy D, Robinson MA, Stefanovski D, Haughan J, Torcivia C, Kowalski A, Ford M, You Y, Missanelli J, Slack J.
J. Vet. Pharmacol. Ther., 2022, 45, 177-187.
Abstract
Use of mitochondrial sequencing to detect gene doping in horses via gene editing and somatic cell nuclear transfer.
Maniego J, Pesko B, Habershon-Butcher J, Hincks P, Taylor P, Tozaki T, Ohnuma A, Stewart G, Proudman C, Ryder E.
Drug Test. Anal., 2022, 14, 1429-1437.
Abstract
Screening for gene doping transgenes in horses via the use of massively parallel sequencing.
Maniego J, Pesko B, Habershon-Butcher J, Huggett J, Taylor P, Scarth J, Ryder E.
Gene Ther., 2022, 29, 236-246.
Abstract
Direct sequence confirmation of qPCR products for gene doping assay validation in horses.
Maniego J, Pesko B, Hincks P, Taylor P, Stewart G, Proudman C, Scarth J, Ryder E.
Drug Test. Anal., 2022, 14, 1017-1025.
Abstract
A separate assay of released and liposomal encapsulated eribulin in dog plasma by liquid chromatography with tandem mass spectrometry for its application to a pharmacokinetic study.
Mano Y.
J. Sep. Sci., 2022, 45, 1636-1645.
Abstract
Clinical effects and pharmacokinetics of nebulized lidocaine in healthy horses.
Minuto J, Bedenice D, Ceresia M, Zaghloul I, Böhlke M, Mazan MR.
Front. Vet. Sci., 2022, 9, 984108.
Abstract
Detection and confirmation of zilpaterol in equine hair using liquid chromatography-mass spectrometry.
Moeller BC, Clifford A, Emery RT, Alarcio G, Favro G, Arthur RM.
Drug Test. Anal., 2022, 14, 31-38.
Abstract
Establishment of a post-race biomarkers database and application of pathway analysis to identify potential biomarkers in post-race equine plasma.
Ohnuma K, Uchida T, Leung GN, Ueda T, Obara T, Ishii H.
Drug Test. Anal., 2022, 14, 915-928.
Abstract
Plasma and urine pharmacokinetics of hydroxyzine and cetirizine following repeated oral administrations to exercised horses.
Paine SW, Aldurdunji M, Garth-Greeves A, Muir T, Hincks PR.
J. Vet. Pharmacol. Ther., 2022, 45, 46-53.
Abstract
Cardiopulmonary effects and pharmacokinetics of dexmedetomidine used as an adjunctive analgesic to regional anesthesia of the oral cavity with levobupivacaine in dogs.
Pavlica M, Kržan M, Nemec A, Kosjek T, Baš A, Seliškar A.
Animals (Basel), 2022, 12, 1217.
Abstract
Pharmacokinetics of paracetamol in the Thoroughbred horse following an oral multi-dose administration.
Pesko B, Habershon-Butcher J, Muir T, Gray B, Taylor P, Fenwick S, Hincks P, Scarth J, Paine S.
J. Vet. Pharmacol. Ther., 2022, 45, 54-62.
Abstract
Metabolic study of hypoxia-inducible factor stabilizers BAY 87-2243, MK-8617, and PT-2385 in equine liver microsomes for doping control.
Philip M, Karakka Kal AK, Mathew B, Subhahar MB, Karatt TK, Perwad Z.
Drug Test. Anal., 2022, 14, 1703-1723.
Abstract
Characterization of growth hormone secretagogue small molecule ibutamoren (MK-0677) and its possible metabolites in thoroughbred horses for doping control.
Philip M, Karakka Kal AK, Subhahar MB, Karatt TK, Mathew B, Koshy SA.
Rapid Commun. Mass Spectrom., 2022, 36, e9337.
Abstract
In vitro studies of hypoxia inducible factor-prolyl hydroxylase inhibitors daprodustat, desidustat and vadadustat for equine doping control.
Philip M, Karakka Kal AK, Subhahar MB, Karatt TK, Mathew B, Perwad Z.
Drug Test. Anal., 2022, 14, 317-348.
Abstract
Pharmacokinetics of cannabidiol following intranasal, intrarectal, and oral administration in healthy dogs.
Polidoro D, Temmerman R, Devreese M, Charalambous M, Ham LV, Cornelis I, Broeckx BJG, Mandigers PJJ, Fischer A, Storch J, Bhatti SFM.
Front. Vet. Sci., 2022, 9, 899940.
Abstract
Pharmacokinetics of diphenhydramine following single-dose intravenous and oral administration in non-fasted adult horses.
Redmond JS, Stang BV, Schlipf JW, Christensen JM.
J. Vet. Pharmacol. Ther., 2022, 45, 188-195.
Abstract
In vivo joint synovial fluid disposition of a novel sustained-release formulation of diclofenac and hyaluronic acid in horses.
Rhodin M, Andersen PH, Forsström KH, Ekstrand C.
J. Vet. Pharmacol. Ther., 2022, 45, 167-176.
Abstract
The pharmacokinetics of a fentanyl matrix patch applied at three different anatomical locations in horses.
Skrzypczak H, Reed R, Brainard B, Sakai D, Barletta M, Quandt J, Smyth C, Ruch M, Kynch H.
Equine Vet. J., 2022, 54, 153-158.
Abstract
Selective inhibition of cyclooxygenase-2 by enflicoxib, its enantiomers and its main metabolites in vitro in canine blood.
Solà J, Menargues À, Homedes J, Salichs M, Álvarez I, Romero L, Vela JM.
J. Vet. Pharmacol. Ther., 2022, 45, 235-244.
Abstract
Pharmacokinetics and anti-nausea effects of intravenous ondansetron in hospitalized dogs exhibiting clinical signs of nausea.
Sotelo CK, Shropshire SB, Quimby J, Simpson S, Gustafson DL, Zersen KM.
J. Vet. Pharmacol. Ther., 2022, 45, 508-515.
Abstract
The equine metabolism of the catechol-O-methyltransferase enzyme inhibitor nitecapone.
Stanley S, Deng D, Van den Berg K, Foo HC.
Drug Test. Anal., 2022, 14, 929-935.
Abstract
Defining the specificity of recombinant human erythropoietin confirmation in equine samples by liquid chromatography-tandem mass spectrometry.
Timms M, Steel R.
Drug Test. Anal., 2022, 14, 676-689.
Abstract
Measurements of hydrocortisone and cortisone for longitudinal profiling of equine plasma by liquid chromatography–tandem mass spectrometry.
Tou K, Cawley A, Bowen C, Sornalingam K, Fu S.
Drug Test. Anal., 2022, 14, 943-952.
Abstract
Control of gene doping in human and horse sports.
Tozaki T, Hamilton NA.
Gene Ther., 2022, 29, 107-112.
Abstract
Sequence determination of phosphorothioated oligonucleotides using MALDI-TOF mass spectrometry for controlling gene doping in equestrian sports.
Tozaki T, Kwak HG, Nakamura K, Takasu M, Ishii H, Ohnuma A, Kikuchi M, Ishige T, Kakoi H, Hirota KI, Kusano K, Hirata M, Nirasawa T, Nagata SI.
Drug Test. Anal., 2022, 14, 175-180.
Abstract
Low-copy transgene detection using nested digital PCR for gene doping control.
Tozaki T, Ohnuma A, Hamilton NA, Kikuchi M, Ishige T, Kakoi H, Hirota KI, Kusano K, Nagata SI.
Drug Test. Anal., 2022, 14, 382-387.
Abstract
Identification of processed pseudogenes in the genome of Thoroughbred horses: Possibility of gene-doping detection considering the presence of pseudogenes.
Tozaki T, Ohnuma A, Kikuchi M, Ishige T, Kakoi H, Hirota KI, Kusano K, Nagata SI.
Anim. Genet., 2022, 53, 183-192.
Abstract
Detection of indiscriminate genetic manipulation in Thoroughbred racehorses by targeted resequencing for gene-doping control.
Tozaki T, Ohnuma A, Nakamura K, Hano K, Takasu M, Takahashi Y, Tamura N, Sato F, Shimizu K, Kikuchi M, Ishige T, Kakoi H, Hirota KI, Hamilton NA, Nagata SI.
Genes (Basel)., 2022, 13, 1589.
Abstract
LC-HRMS/MS study of the prodrug ciclesonide and its active metabolite desisobutyryl-ciclesonide in plasma after an inhalative administration to horses for doping control purposes.
Trevisiol S, Moulard Y, Kaabia Z, Delcourt V, Loup B, Garcia P, Boyer S, Dauriac K, Groseille G, Rouger S, Narbe R, Popot MA, Bailly-Chouriberry L.
Drug Test. Anal., 2022, 14, 252-261.
Abstract
Pharmacokinetics of cannabidiol in a randomized crossover trial in senior horses.
Turner SE, Knych HK, Adams AA.
Am. J. Vet. Res., 2022, 83, ajvr.22.02.0028.
Abstract
Differentiation of boldenone administration from ex vivo transformation in the urine of castrated male horses.
Viljanto M, Kaabia Z, Taylor P, Muir T, Habershon-Butcher J, Bailly-Chouriberry L, Scarth J.
Drug Test. Anal., 2022, 14, 887-901.
Abstract
Pharmacokinetics of fluoxetine in horses following oral administration.
Waitt Wolker LH, Veltri CA, Pearman K, Lozoya M, Norris JW.
J. Vet. Pharmacol. Ther., 2022, 45, 63-68.
Abstract
Simultaneous determination of eight analytes of Fuzheng Huayu recipe in beagle dog plasma by UHPLC-Q/Exactive Orbitrap HRMS and its application to toxicokinetics.
Wang YL, Yang M, Li RS, Hu YQ, Pan YF, Tao Y.
Biomed. Chromatogr., 2022, 36, e5329.
Abstract
Pharmacokinetic evaluation of a cannabidiol supplement in horses.
Williams MR, Holbrook TC, Maxwell L, Croft CH, Ientile MM, Cliburn K.
J. Equine Vet. Sci., 2022, 110, 103842.
Abstract
Pharmacokinetics, safety, and synovial fluid concentrations of single- and multiple-dose oral administration of 1 and 3 mg/kg cannabidiol in horses.
Yocom AF, O'Fallon ES, Gustafson DL, Contino EK.
J. Equine Vet. Sci., 2022, 113, 103933.
Abstract
Simultaneous determination and pharmacokinetic study of six components in beagle dog plasma by UPLC-MS/MS after oral administration of Astragalus membranaceus aqueous extract.
Yu X, Xia K, Wu S, Wang Q, Cheng W, Ji C, Yang W, Kang C, Yuan Z, Li Y.
Biomed. Chromatogr., 2022, 36, e5488.
Abstract
A fully automated method to quantitate total carbon dioxide in equine plasma by headspace GCMS.
Zahra PW, Jayasinghe NS, Selvadurai NS, Willers SJ, Krsta D, Batty DC, Vine JH.
Drug Test. Anal., 2022, 14, 1724-1731.
Abstract
Characterization of the metabolites of tirabrutinib generated from rat, dog and human liver microsomes by ultra-high performance liquid chromatography combined with high resolution mass spectrometry.
Zhang H, Hu Z, Zhang H, Sun X, Yang J, Yuan J.
Rapid Commun. Mass Spctrom., 2022, 15, e9240.
Abstract
