2023 Articles
Pharmacokinetics and pharmacodynamics of intramuscular dexmedetomidine in dogs.
Aarnes TK, Dent BT, Lakritz J, KuKanich B, Wavreille VA, Lerche P, Ricco Pereira CH, Bednarski RM.
Am. J. Vet. Res., 2023, 84, ajvr.22.10.0184.
Abstract
Single-dose pharmacokinetics of telmisartan oral solution and effect of feeding in dogs.
Bechtel AG, Reinhart JM, Li Z.
J. Vet. Pharmacol. Ther., 2023, 46, 17-24.
Abstract
Equine in vivo metabolite profiling of the selective androgen receptor modulator LGD-3303 for doping control.
Broberg MN, Knych H, Bondesson U, Pettersson C, Tidstedt B, Stanley S, Thevis M, Hedeland M.
J. Pharm. Biomed. Anal., 2023, 233, 115468.
Abstract
Tolerability and pharmacokinetics of intravenous allopregnanolone with and without midazolam pretreatment in two healthy dogs.
Bruun DA, Ma B, Chen YJ, Wu CY, Aleman M, Zolkowska D, Smiley-Jewell SM, Rogawski MA, Lein PJ.
Epilepsia Open, 2023, 8, 666-672.
Abstract
Pharmacokinetics of intra-articular buprenorphine in horses with lipopolysaccharide-induced synovitis.
Castro-Cuellar G, Cremer J, Queiroz-Williams P, Knych HK, Leise BS.
J. Vet. Pharmacol. Ther., 2023, 46, 229-237.
Abstract
A validated chiral LC-MS/MS method for the enantioselective determination of (S)-(+)- and (R)-(-)-ibuprofen in dog plasma: Its application to a pharmacokinetic study.
Choi S, Shim WS, Yoon J, Choi D, Lee J, Paik SH, Chung EK, Lee KT.
Pharmaceutics, 2023, 15, 824.
Abstract
Performance assessment of an equine metabolomics model for screening a range of anabolic agents.
Cloteau C, Dervilly G, Loup B, Delcourt V, Kaabia Z, Bagilet F, Groseille G, Dauriac K, Fisher S, Popot MA, Garcia P, Le Bizec B, Bailly-Chouriberry L.
Metabolomics, 2023, 19, 38.
Abstract
TB500/TB1000 and SGF1000: A scientific approach for a better understanding of misbranded and adulterated drugs.
Delcourt V, Garcia P, Chabot B, Barnabé A, Bouscarel M, Loup B, Popot MA, Bailly-Chouriberry L.
Drug Test. Anal., 2023, 15, 458-464.
Abstract
Pharmacokinetics of dexmedetomidine in anesthetized horses: Comparison between repeated subcutaneous administration and continuous rate infusion.
Di Cesare F, Draghi S, Amari M, Rabbogliatti V, Brioschi FA, Villa R, Ravasio G, Cagnardi P.
J. Vet. Pharmacol. Ther., 2023, 46 (S1), 31.
Abstract
Pharmacokinetics, efficacy, and safety of cannabidiol in dogs: an update of current knowledge.
Di Salvo A, Conti MB, Della Rocca G.
Front. Vet. Sci., 2023, 10, 1204526.
Abstract
A review of current chemistry, pharmacology, and regulation of endogenous anabolic steroids testosterone, boldenone, and nandrolone in horses.
Dirikolu L, Lehner AF.
J. Vet. Pharmacol. Ther., 2023, 46, 201-217.
Abstract
Total carbon dioxide (TCO2) concentrations in Thoroughbred and Quarter racehorses in Louisiana.
Dirikolu L, Waller P, Malveaux K, Lucas CH, Lomnicka I, Pourciau A, Bennadji H, Liu C CC.
J. Equine Vet. Sci., 2023, 121, 104220.
Abstract
Pharmacokinetic modeling of orally administered cannabidiol and implications for medication control in horses.
Eichler F, Poźniak B, Machnik M, Schenk I, Wingender A, Baudisch N, Thevis M, Bäumer W, Lischer C, Ehrle A.
Front. Vet. Sci., 2023, 10, 1234551.
Abstract
Factors affecting untargeted detection of doping agents in biological samples.
Guan F, You Y, Fay S, Adreance MA, McGoldrick LK, Robinson MA.
Talanta, 2023, 258, 124446.
Abstract
Equine metabolism of the selective androgen receptor modulator YK-11 in urine and plasma following oral administration.
Harding C, Viljanto M, Habershon-Butcher J, Taylor P, Scarth J.
Drug Test. Anal., 2023, 15, 388-407.
Abstract
Administration and detection of gene therapy in horses: A systematic review.
Haughan J, Ortved KF, Robinson MA.
Drug Test. Anal., 2023, 15, 143-162.
Abstract
The pharmacokinetics of fentanyl administered via transdermal matrix patch applied to at three different dosages in horses.
Holmes BT, Krikorian AM, Reynolds RM, Berghaus L, Knych H, Reed RA.
J. Vet. Pharmacol. Ther., 2023, 46 (S1), 49.
Abstract
First evidence of the incorporation of daprodustat and other hypoxia-inducible factor stabilizers into equine hair by passive transfer based on segmental quantitative analysis.
Ishii H, Shibuya M, Kusano K, Sone Y, Kamiya T, Wakuno A, Ito H, Miyata K, Yamada M, Leung GN.
J. Pharm. Biomed. Anal., 2023, 235, 115600.
Abstract
Segmental analysis and long-term monitoring of vadadustat in equine hair for the purpose of doping control.
Ishii H, Shibuya M, Kusano K, Sone Y, Kamiya T, Wakuno A, Ito H, Miyata K, Yamada M, Leung GN.
J. Anal. Toxicol., 2023, 47, 623-631.
Abstract
Cocktail drug usage and etofenamate detection in post-race equine urine sample: A case report.
Kabil E, Göktaş EF, Güneş E, Yatanaslan L, Zor TA, Tektaş MH, Inceman B, Tufan M.
Biomed. Chromatogr., 2023, 37, e5556.
Abstract
Electrospray ionisation mass spectrometry adduct formation by mobile phase additives: A case study using nitrile functional groups containing selective androgen receptor modulators (SARMs).
Karatt TK, Muhammed Ajeebsanu MP, Karakka Kal AK, Subhahar MB, Sathiq MA, Laya S.
Rapid Commun. Mass Spectrom., 2023, 37, e9530.
Abstract
An extensive screening method for the identification and quantitation of ecdysteroids in equine urine and plasma using liquid chromatography coupled with mass spectrometry.
Karatt TK, Sathiq MA, Laya S, Muhammed Ajeebsanu MP, Karakka Kal AK, Subhahar MB, Perwad Z.
Rapid Commun. Mass Spectrom., 2023, 37, e9611.
Abstract
Metabolic study of selective androgen receptor modulator LY2452473 in thoroughbred horses for doping control.
Karatt TK, Sathiq MA, Laya S, Karakka Kal AK, Subhahar MB, Muhammed Ajeebsanu MP, Philip M, Graiban FM, Caveney MR.
Rapid Commun. Mass Spectrom., 2023, 37, e9491.
Abstract
In-depth metabolic study of non-steroidal selective androgen receptor modulator GSK2881078 in thoroughbred horses and horse liver microsomes for doping control.
Karatt TK, Sathiq MA, Laya S, Karakka Kal AK, Subhahar MB, Muhammed Ajeebsanu MP, Philip M, Caveney MR, Graiban FM.
Drug Test. Anal., 2023, 15, 757-768.
Abstract
Investigation of in vitro generated metabolites of GLPG0492 using equine liver microsomes for doping control.
Karatt TK, Sathiq MA, Laya S, Philip M, Karakka Kal AK, Subhahar MB.
Drug Test. Anal., 2023, 15, 605-628.
Abstract
3-Methoxytyrosine as an indicator of dopaminergic manipulation in equine plasma.
Keen B, Cawley A, Reedy B, Noble G, Loy J, Fu S.
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 2023, 1220, 123652.
Abstract
Identification of potential miRNA biomarkers to detect hydrocortisone administration in horses.
Kikuchi M, Ishige T, Minamijima Y, Hirota KI, Nagata SI, Tozaki T, Kakoi H, Ishiguro-Oonuma T, Kizaki K.
Int. J. Mol. Sci., 2023, 24, 14515.
Abstract
Clodronate detection and effects on markers of bone resorption are prolonged following a single administration to horses.
Knych HK, Finno CJ, Katzman S, Ryan D, McKemie DS, Kass PH, Arthur RM.
Equine Vet. J., 2023, 55, 696-706.
Abstract
Pharmacokinetics and metabolism of lidocaine HCl 2% with epinephrine in horses following a palmar digital nerve block.
Knych HK, Katzman S, McKemie DS, Arthur RM, Blea J.
BMC Vet. Res., 2023, 19, 225.
Abstract
Long-term monitoring of clodronate in equine hair using liquid chromatography-tandem mass spectrometry.
Knych HK, McKemie DS, Yim S, Stanley SD, Arthur RM.
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 2023, 1226, 123789.
Abstract
Identification of a metabolite for the detection of the hydrophilic drug diisopropylamine for doping control.
Kwak YB, Choi MS.
J. Pharm. Biomed. Anal., 2023, 234, 115576.
Abstract
Pharmacokinetics of the novel 5-HT4 receptor agonist, DA-6886, in dogs.
Lee DY, Kang HE.
Xenobiotica, 2023, 53, 438-444.
Abstract
Preclinical pharmacokinetics and metabolism study of SCO-267, a GPR40 full agonist, in beagle dogs using ultra-high performance liquid chromatography coupled to tandem mass spectrometry.
Li H, Liu Y, Xiao J, Huang J, Zhang Y.
Biomed. Chromatogr., 2023, 37, e5685.
Abstract
Absorption, metabolism, and excretion of taselisib (GDC-0032), a potent β-sparing PI3K inhibitor, in rats, dogs, and humans.
Ma S, Cho S, Sahasranaman S, Zhao W, Pang J, Ding X, Dean B, Wang B, Hsu JY, Ware J, Salphati L.
Drug Metab. Dispos., 2023, 53, 436-450.
Abstract
UPLC-MS/MS method development and application to pharmacokinetic study in rats and dogs of flonoltinib maleat.
Ma Z, Tang M, Pu Q, Wei P, Wu R, Zhao J, Zhou Y, Yang Z, Ye H, Chen L.
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 2023, 1223, 123696.
Abstract
Long-read sequencing assays designed to detect potential gene editing events in the myostatin gene revealed distinct haplotype signatures in the Thoroughbred horse population.
Maniego J, Giles O, Hincks P, Stewart G, Proudman C, Ryder E.
Anim. Genet., 2023, 54, 470-482.
Abstract
Pharmacokinetics of aminocaproic acid in Thoroughbred horses.
Maxwell L, McCarrel TM, Hay S, Cole C.
J. Vet. Pharmacol. Ther., 2023, 46, 250-256.
Abstract
Pharmacokinetics, clinical efficacy and safety of acetaminophen (paracetamol) in adult horses with naturally occurring chronic lameness.
Mercer MA, Davis JL, McKenzie HC, Byron CR, Kelleher ME, Trager L, Cecere TE, Wilson KE, Council-Troche RM, Werre SR.
Equine Vet. J., 2024, 56, 202-214.
Abstract
Pharmacokinetics and clinical efficacy of acetaminophen (paracetamol) in adult horses with mechanically induced lameness.
Mercer MA, McKenzie HC, Byron CR, Pleasant RS, Bogers SH, Council-Troche RM, Werre SR, Burns T, Davis JL.
Equine Vet. J., 2023, 55, 524-533.
Abstract
Comprehensive metabolite profiling of trimetazidine in camels using high-resolution accurate mass spectrometry: Implications for doping control.
Nalakath J, Pt R, Kadry A, Palathinkal AB, Praseen OK, Nelliyott I, Hebel C, Selvapalam N, Nagarajan ER.
Rapid Commun. Mass Spectrom., 2023, 37, e9626.
Abstract
Phenylbutazone concentrations in synovial fluid following administration via intravenous regional limb perfusion in the forelimbs of six adult horses.
O'Brien M, Mochel JP, Kersh K, Wang C, Troy J.
Front. Vet. Sci., 2023, 10, 1236976.
Abstract
Multiplex detection of transgenes using πCode technology for gene doping control.
Ohnuma A, Tozaki T, Kikuchi M, Ishige T, Kakoi H, Hirota KI, Takahashi Y, Nagata SI.
Anal. Chem., 2023, 95, 10149-10154.
Abstract
Investigation of in vitro generated metabolites of LGD-4033, a selective androgen receptor modulator, in homogenized camel liver for anti-doping applications.
Ondern Komathu P, Padusha MKSA, Laya S, Nalakath J, Palathinkal AB, Nelliyott I.
Rapid Commun. Mass Spectrom., 2023, 37, e9633.
Abstract
Novel holistic pharmacokinetic model applied to plasma and urine concentrations of 2,5-dihydroxybenzene sulphonate following administrations of calcium dobesilate and etamsylate to exercised horses.
Paine SW, Harding C, Waller CC, Zemenova J, Viljanto M, Habershon Butcher J, Hincks PR.
J. Vet. Pharmacol. Ther., 2023, 46, 365-374.
Abstract
Hydroxy levamisole and its phase II conjugates as potential indicators of levamisole doping in thoroughbred horses.
Philip M, Karakka Kal AK, Subhahar MB, Karatt TK, Mathew B, Perwad Z, Graiban FM, Caveney MR, Sayed R, Kadry AM.
Rapid Commun. Mass Spectrom., 2023, 37, e9430.
Abstract
Concentrations, pharmacokinetics and selected pharmacodynamics of morphine and its active metabolites following oral administration to horses.
Poth MKM, McKemie DS, Traynham M, Kass PH, Knych HK.
J. Vet. Pharmacol. Ther., 2023, 46, 238-249.
Abstract
The in vivo metabolism of Jungle Warfare in greyhounds.
Pranata A, Yamada S, Weththasinghe S, Caldwell K, Zahra PW, Karamatic SL, Gardiner MG, McLeod MD.
Steroids, 2023, 190, 109150.
Abstract
Citalopram in vitro metabolism in a beagle dog: A role for CYP2D15 in the production of toxic didesmethylcitalopram?.
Rochat B, Paus E, Maitre C, Baumann P.
Vet. Med. (Praha), 2023, 68, 135-144.
Abstract
Pharmacokinetics and oral bioavailability of cannabidiol in horses after intravenous and oral administration with oil and micellar formulations.
Sánchez de Medina A, Serrano-Rodríguez JM, Díez de Castro E, García-Valverde MT, Saitua A, Becero M, Muñoz A, Ferreiro-Vera C, Sánchez de Medina V.
Equine Vet. J., 2023, 55, 1094-1103.
Abstract
Control of a sulfadoxine/trimethoprim combination in the competition horse: Elimination, metabolism and detection following an intravenous administration.
Schenk I, Broussou D, Roques B, Lagershausen H, Machnik M, Röttgen H, Toutain PL, Thevis M.
Drug Test. Anal., 2023, 15, 629-645.
Abstract
Innovative detection of testosterone esters in camel hair: Unravelling the mysteries of dromedary endocrinology.
Shah I, Hakeem MK, Alraeesi A, Barker J.
Molecules, 2023, 29, 97.
Abstract
Effect of storage duration on carprofen concentration measurements in dog plasma.
Shuttleworth JR, Behrens KN, Biggo MR, Horne RL, Cox S, Lakritz J, Tinga S.
Vet. Med. Sci., 2023, 9, 2022-2025.
Abstract
Short insertion and deletion discoveries via whole-genome sequencing of 101 Thoroughbred racehorses.
Tozaki T, Ohnuma A, Kikuchi M, Ishige T, Kakoi H, Hirota KI, Takahashi Y, Nagata SI.
Genes (Basel), 2023, 14, 638.
Abstract
Pharmacokinetics and effects of codeine in combination with acetaminophen on thermal nociception in horses.
Tueshaus T, McKemie DS, Kanarr K, Kass PH, Knych HK.
J. Vet. Pharmacol. Ther., 2023, 46, 311-325.
Abstract
Detection of the growth hormone secretagogue MK-0677 in equine hair following oral administration.
Viljanto M, Cutler C, Taylor P, Habershon-Butcher J, Gray B.
Drug Test. Anal., 2023, 15, 361-367.
Abstract
A multiplex qPCR assay for transgenes detection - a novel approach for gene doping control in horseracing using conventional laboratory setup.
Wong KS, Cheung HW, Szeto CWL, Tsang CYN, Wan TSM, Ho ENM.
Drug Test. Anal., 2023, 15, 879-888.
Abstract
Development and validation a UPLC-MS/MS method for quantification of pentoxifylline in beagle plasma: Application for pharmacokinetic study of food effect.
Xu Y, Gao X, Zhu Y, Zhang Q, Qie H, Zhao H, Gao J, Wang M.
Drug Des. Devel. Ther., 2023, 17, 3551-3561.
Abstract
Use of liquid chromatography-tandem mass spectrometry to quantify and confirm the fentanyl metabolite N-[1-(2-phenethy-4-piperidinyl)]maloanilinic acid in equine urine for doping control.
You Y, Proctor RM, Haughan J, Missanelli JR, Robinson MA.
J. Anal. Toxicol., 2023, 47, 393-402.
Abstract
Trace quantification of GL-V9 and its glucuronide metabolites (5-O-glucuronide GL-V9) in beagle dog plasma by UPLC-MS/MS and its application to a pharmacokinetic study.
Zhang X, Liu G, Sang Z, Guo Q, Zhou Y.
PLoS One, 2023, 18, e0286467.
Abstract
