2024 Articles
Accepted articles
Doping control analysis of methylsulfonylmethane in horses.
Wong JKY, Choi TLS, Wong COL, Curl P, Wan TSM, Ho ENM.
Drug Test. Anal., DOI 10.1002/dta.3844.
Abstract
Detection of over 110 anabolic-androgenic steroids, corticosteroids and/or their esters in horse hair using ultra-high-performance liquid chromatography-high-resolution nass spectrometry and gas chromatography-tandem mass spectrometry after solid-supported liquid extraction.
So YM, Kwok WH, Ching CCW, Wong COL, Wan TSM, Ho ENM.
Drug Test. Anal., DOI 10.1002/dta.3837.
Abstract
Doping control analysis of total carbon dioxide (TCO2) in equine plasma by headspace gas chromatography-mass spectrometry (HS-GC/MS).
Kwok KY, Kwok WH, Wan TSM, Brooks L, Popot MA, Jaubert M, Bailly-Chouriberry L, Heffron BT, Choo CK, Tso J, Tso R, McKenzie B, Selvadurai N, Batty D, Gray B, Hudson A, Ragazzoni S, Claudio M, Ho ENM.
Drug Test. Anal., DOI 10.1002/dta.3832.
Abstract
Investigation into the equine metabolism of phosphodiesterase-4 inhibitor roflumilast for potential doping control.
Philip M, Karakka Kal AK, Subhahar MB, Karatt TK, Graiban FM, Ajeebsanu MM, Joseph M, Jose SV.
Drug Test. Anal., DOI 10.1002/dta.3822.
Abstract
New transcriptomic biomarkers for detection of the recombinant human erythropoietin (rHuEPO) MirCERA in horses.
Loup B, André F, Leuenberger N, Marchand A, Barnabé A, Delcourt V, Garcia P, Popot MA, Bailly-Chouriberry L.
Drug Test. Anal., DOI 10.1002/dta.3812.
Abstract
Discovery of biomarkers of a recombinant human erythropoietin administration to Thoroughbred geldings by label-free proteomics.
Cheung HW, Wong KS, Tam JCL, Farrington AF, Bond AJ, Wan TSM, Ho ENM.
Drug Test. Anal., DOI 10.1002/dta.3810.
Abstract
Equine doping controls of thymosin β4: A population study and strategy for misuse detection.
Delcourt V, Garcia P, Chabot B, Aber N, Pescher M, Cacault M, Scholtes P, Loup B, Barnabé A, Popot MA, Bailly-Chouriberry L.
Drug Test. Anal., DOI 10.1002/dta.3806.
Abstract
Pharmacokinetics of ethyl glucuronide and ethyl sulfate and pharmacodynamic effects following intravenous and oral administration of ethanol to exercised horses.
Knych HK, Blea J, Scollay M, Kass PH, McKemie DS.
Drug Test. Anal., DOI 10.1002/dta.3803.
Abstract
Doping control analysis of perfluorocarbons in equine plasma by headspace gas chromatography-tandem mass spectrometry.
Kong FKW, Wong ASY, Cheung RKK, Wan TSM, Ho ENM.
Drug Test. Anal., DOI 10.1002/dta.3801.
Abstract
High-throughput equine doping controls on a trapped ion mobility quadrupole-time-of-flight mass spectrometer: Technical considerations of dia/slice/prmPASEF applied to the long-term detection of monoclonal antibodies.
Delcourt V, Pinetre J, Chabot B, Barnabé A, Cacault M, Loup B, Becher F, Fenaille F, Popot MA, Garcia P, Bailly-Chouriberry L.
Drug Test. Anal., DOI 10.1002/dta.3797.
Abstract
Bayesian individual limits for IGF-1 monitoring in equine plasma: Implementation in the equine biological passport.
Barnabé A, Loup B, Cawley A, Delcourt V, Garcia P, Popot MA, Keledjian J, Bailly-Chouriberry L.
Drug Test. Anal., DOI 10.1002/dta.3795.
Abstract
In vivo comparative study of hemp straw exposure and cannabidiol oil administration in horse urine.
Trevisiol S, Popot MA, Garcia P, Boyer S, Caroff M, Drif L, Taleb W, Tendon S, Moulard Y, Bailly-Chouriberry L.
Drug Test. Anal., DOI 10.1002/dta.3783.
Abstract
Development and validation of general plasma screening method for performance enhancing drugs in racehorses utilizing liquid chromatography-high-resolution mass spectrometry (LC-HRMS).
Lomnicka I, Dubey S, Waller P, Vora D, Dirikolu L.
Drug Test. Anal., DOI 10.1002/dta.3774.
Abstract
Published articles
Detection of levamisole and its metabolites in horses after oral levamisole administration over seven days.
Adam E, Scollay M, Howard B, Taormina J, Hartmann P, Knych H.
J. Am. Vet. Med. Assoc., 2024, 262, 1632-1638.
Abstract
The effects of food on the pharmacokinetics of mycophenolate mofetil in healthy horses.
Bello K, Lorch G, Papich MG, Kim K, Toribio RE, Yan L, Xie Z, Hill K, Phelps MA.
J. Vet. Pharmacol. Ther., 2024, 47, 280-287.
Abstract
UPLC-MS/MS analysis of axitinib and pharmacokinetic application in beagle dogs.
Bi H, Wang Y, Ding X, Li J, Qi H, Qiu X.
Heliyon., 2024, 10, e39422.
Abstract
Evaluation of pharmacokinetics of metoclopramide administered via subcutaneous bolus and intravenous constant rate infusion to adult horses.
Brandon AM, Williams JM, Davis JL, Martin EG, Capper AM, Crabtree NE.
Vet. Surg., 2024, 53, 1111-1122.
Abstract
Simultaneous determination of five compounds of fried Radix Paeoniae Alba extract in beagle dogs plasma by ultra performance liquid chromatography tandem mass spectrometry and its application in a pharmacokinetic study.
Cheng W, Yuan Z, Wu S, Yu X, Xia K, Zhao L, Wang Y, Kang C, Yang W, Liu L, Li Y.
Biomed. Chromatogr., 2024, 38, e5803.
Abstract
Identification of the dermorphin tetrapeptide [Dmt1]-DALDA in a seized unlabelled vial and its first detection in horse urine: A case report.
Choi TLS, Lau MY, Wong JKY, Wan TSM, Ho ENM.
Drug Test. Anal., 2024, 16, 268-276.
Abstract
Pharmacokinetics of subcutaneous ketamine administration via the Omnipod® system in dogs.
Colón C, Early P, Muñana K, Olby N, Mariani C, Mancini S, Fefer G, Li Z, Briley J, Bailey K, Lascelles D, Messenger K.
J. Vet. Pharmacol. Ther., 2024, 47, 353-358.
Abstract
Cannabidiol and cannabidiolic acid: Preliminary in vitro evaluation of metabolism and drug-drug interactions involving canine cytochrome P-450, UDP-glucuronosyltransferase, and P-glycoprotein.
Court MH, Mealey KL, Burke NS, Jimenez TP, Zhu Z, Wakshlag JJ.
J. Vet. Pharmacol. Ther., 2024, 47, 1-13.
Abstract
Detection of FG-4592 and metabolites in equine plasma, urine and hair following oral administration.
Cutler C, Viljanto M, Taylor P, Hincks P, Habershon-Butcher J, Gray B, Scarth J.
Drug Test. Anal., 2024, 16, 1167-1181.
Abstract
Assessment of remdesivir and its nucleoside metabolite in beagle dogs and healthy humans by liquid chromatography coupled with triple quadrupole mass spectrometry.
Dubey NK, Jain P, Raj A, Tiwari S.
Biomed. Chromatogr., 2024, 10, e5965.
Abstract
Exploring montelukast in dogs: a preliminary pharmacokinetic study following oral administration under fasted and fed conditions.
Fadel C, Łebkowska-Wieruszewska B, Lisowski A, Serih F, Poapolathep A, Giorgi M.
Vet. J., 2024, 307, 106210.
Abstract
Detection of doping peptides and basic drugs in equine urine using liquid chromatography-mass spectrometry.
Flores L, Hargrave S, Clifford A, Alarcio G, Moeller BC.
Drug Test. Anal., 2024, 16, 406-419.
Abstract
Non-targeted detection of synthetic oligonucleotides in equine serum using liquid chromatography-high-resolution mass spectrometry.
Helmes E, Montgomery J, Alarcio G, Mendoza HG, Blea JA, Beal PA, Moeller BC.
Int. J. Mol. Sci., 2024, 25, 5752.
Abstract
The effects of formulation on the pharmacokinetics of itraconazole and amiodarone in dogs after oral administration of a combination product, commercial products, and compounded products.
Hunter RP, Madigan R.
J. Vet. Pharmacol. Ther., 2024, 47, 65-72.
Abstract
Pharmacokinetic study of osilodrostat and identification of mono-hydroxylated metabolite in equine plasma for the purpose of doping control.
Ishii H, Ishikawa Y, Mizobe F, Nomura M, Yamanaka T, Tanabe S, Nagata SI, Yamada M, Leung GN.
Rapid Commun. Mass Spectrom., 2024, 38, e9695.
Abstract
Metabolic pathway of osilodrostat in equine urine established through high-resolution mass spectrometric characterization for doping control.
Ishii H, Shigematsu R, Takemoto S, Ishikawa Y, Mizobe F, Nomura M, Arima D, Kunii H, Yuasa R, Yamanaka T, Tanabe S, Nagata SI, Yamada M, Leung GN.
Curr. Drug Metab., 2024, 25, 489-504.
Abstract
Quantification of osilodrostat in horse urine using LC/ESI-HRMS to establish an elimination profile for doping control.
Ishii H, Shigematsu R, Takemoto S, Ishikawa Y, Mizobe F, Nomura M, Arima D, Kunii H, Yuasa R, Yamanaka T, Tanabe S, Nagata SI, Yamada M, Leung GN.
Bioanalysis, 2024, 16, 947-958.
Abstract
Pharmacokinetics and tolerability of a veterinary phenobarbital product in healthy dogs.
Jukier T, Gross A, Boothe D.
Front. Vet. Sci., 2024, 10, 1307888.
Full article
Detection of sildenafil and its 9 metabolites in a post-race horse urine sample: A case report.
Kabi L E, Zor TA, Göktaş EF, Güneş E, Yatanaslan L, Tektaş MH, İnceman B, Tufan M.
J. Pharm. Biomed. Anal., 2024, 249, 116343.
Abstract
Analysis of the polymeric mixture in hypoxen, using high-performance liquid chromatography coupled with high-resolution mass spectrometry.
Karakka Kal AK, Subhahar MB, Philip M, Karatt TK.
Rapid. Commun. Mass Spectrom., 2024, 38, e9918.
Abstract
Ketoprofen in horses: Metabolism, pharmacokinetics, and effects on inflammatory biomarkers.
Knych HK, McKemie DS, Kass PH, Stanley SD, Blea J.
Drug Test. Anal., 2024, 16, 289-302.
Abstract
Pharmacokinetics and thermal anti-nociceptive effects of oral morphine in horses.
Knych HK, Steinmetz SJ, Traynham ML, McKemie DS, Kass PH.
Front. Vet. Sci., 2024, 11, 1461648.
Abstract
Population pharmacokinetics of butorphanol following intramuscular administration to exercised thoroughbred horses.
Knych HK, Weiner D, McKemie DS, Traynham M, Blea J.
J. Vet. Pharmacol. Ther., 2024, 47, 372-379.
Abstract
Rational quinidine dosage regimen for atrial fibrillation in Thoroughbred racehorses based on population pharmacokinetics.
Kuroda T, Minamijima Y, Kinman CK, Takahashi Y, Ebisuda Y, Inoue K, Ishikawa H, Mita H, Tamura N, Nukada T, Toutain PL, Ohta M.
Front. Vet. Sci., 2024, 11, 1454342.
Abstract
Rapid investigating of phase I metabolites of SR9009 in vitro horse liver microsomes via feature-based molecular networking approach: Potential applications in doping control.
Kwak YB, Yoon J, Yoo HH.
J. Pharm. Biomed. Anal., 2024, 246, 116190.
Abstract
The stereoselective pharmacokinetics of the desmethyl-phencynonate hydrochloride in beagle dogs.
Li J, Yin L, Li Y, Sun J, Wang X, Zhang Z, Xiong S.
Chirality, 2024, 36, e23669.
Abstract
Pharmacokinetics behavior of four cannabidiol preparations following single oral administration in dogs.
Limsuwan S, Phonsatta N, Panya A, Asasutjarit R, Tansakul N.
Front. Vet. Sci., 2024, 11, 1389810.
Full article
omparative analysis of posiphen pharmacokinetics across different species-similar absorption and metabolism in mouse, rat, dog and human.
Maccecchini ML, Mould DR.
Biomolecules, 2024, 14, 582.
Full article
Administration and detection of a multi-target rAAV gene doping vector in horses using multiple matrices and molecular techniques.
Maniego J, Harding C, Habershon-Butcher J, Hincks P, Ryder E.
Gene Ther., 2024, 31, 477-488.
Abstract
Evaluation of plasma and urine pharmacokinetics of tranexamic acid for equine medication control.
Minamijima Y, Kuroda T, Kamiya T, Sone Y, Wakuno A, Ito H, Nomura M, Leung GN, Kinoshita K, Yamada M.
J. Vet. Pharmacol. Ther., 2024, 47, 21-27.
Abstract
Comprehensive metabolic investigation of dopamine reuptake inhibitor HDMP-28 in equine liver microsomes and Cunninghamella elegans for doping control.
Muhammed Ajeebsanu M, Subhahar MB, Karakka Kal AK, Philip M, Perwad Z, Karatt TK, Graiban FM, Joseph M, Jose SV.
Drug Test. Anal., 2024, 16, 1182-1194.
Abstract
Characterizing lomerizine metabolites in camel urine: High-resolution mass spectrometry method development and validation for enhanced doping control.
Nalakath J, Rasik RP, Kadry A, Babu A, Waseem I, Ok P, Hebel C, Selvapalam N, Nagarajan ER.
Rapid Commun. Mass Spectrom., 2024, 38, e9846.
Abstract
Pharmacokinetics, pharmacodynamics and antinociceptive effects of buprenorphine following transdermal administration to horses.
Nelson GR, Mama KR, Weiner D, McKemie DS, Kass PH, Steinmetz SJ, Knych HK.
Vet. Anaesth. Analg., 2024, 51, 520-530.
Abstract
A broad-spectrum peptide screening method using an optimized solid-phase extraction and liquid chromatography-high-field asymmetric ion mobility spectrometry-mass spectrometry for doping control in equine urine.
Ohnuma K, Hirano-Kodaira M, Bannai M, Shimizu Y, Yamada M, Kinoshita K, Ngai-Wa Leung G, Ishii H.
Anal. Methods, 2024, 16, 8250-8267.
Abstract
Stereoselective pharmacokinetics of ketamine administered at a low dose in awake dogs.
Pargätzi G, Bergadano A, Spadavecchia C, Theurillat R, Thormann W, Levionnois OL.
J. Vet. Pharmacol. Ther., 2024, 14, 1012.
Abstract
Detection times of clodronic acid in horses with orthopedic disease.
Pedrosa BS, Dujardin C, Moses B, Thompson C, Sarasola P, Gattacceca F, Loup B, Garcia P, Popot MA, Bailly-Chouriberry L.
J. Vet. Pharmacol. Ther., 2024, 47, 380-389.
Abstract
Equine metabolic investigation of the phosphodiesterase-4 inhibitor ibudilast as a potential performance enhancer.
Philip M, Karakka Kal AK, Subhahar MB, Karatt TK, Graiban FM, Ajeebsanu MM, Joseph M, Jose SV.
Rapid. Commun. Mass Spectrom., 2024, 38, e9916.
Abstract
High-throughput untargeted screening of biotherapeutic macromolecules in equine plasma by UHPLC-HRMS/MS: Application to monoclonal antibodies and Fc-fusion proteins for doping control.
Pinetre J, Delcourt V, Becher F, Garcia P, Barnabé A, Loup B, Popot MA, Fenaille F, Bailly-Chouriberry L.
Drug Test. Anal., 2024, 16, 199-209.
Abstract
The pharmacokinetics and pharmacodynamics of fentanyl administered via transdermal patch in horses.
Reed RA, Berghaus LJ, Reynolds RM, Holmes BT, Krikorian AM, Sakai DM, Ishikawa Y, Knych HK.
Front. Pain Res. (Lausanne), 2024, 5, 1373759.
Full article
Identification and differentiation of somapacitan, a long-acting growth hormone derivative, and recombinant human growth hormone in equine plasma by LC-HRMS for doping control purpose.
Shimizu Y, Sugai-Bannai M, Saito K, Hirano-Kodaira M, Leung GN.
Growth Horm. IGF Res., 2024, 80, 101628.
Abstract
Identification of erythropoietin mimetic peptide 1 linear form in a sealed vial and its administration study in horses for doping control purpose.
So YM, Wong JKY, Wong ASY, Tse ATL, Wan TSM, Ho ENM.
Drug Test. Anal., 2024, 16, 71-82.
Abstract
Development of a simple and validated LC-MS/MS method for quantitative determination of ketotifen in beagle dog plasma and its application to bioequivalence study of ketotifen syrup dosage form.
Song E, Shim WS, Choi D, Song Y, Jo HG, Lee S, Jung SH, Choi YJ, Lee KT.
Molecules, 2024, 29, 4505.
Abstract
Doping control approach: Identification of equine in vitro metabolites of voxelotor (GBT440), a hemoglobin S polymerization inhibitor.
Subhahar MB, Karakka Kal AK, Philip M, Muhammed Ajeebsanu M, Karatt TK, Perwad Z.
Rapid Commun. Mass Spectrom., 2024, 38, e9671.
Abstract
Population pharmacokinetics, pharmacodynamics and safety properties of trametinib in dogs with cancer: A phase I dose escalating clinical trial.
Takada M, Kitagawa K, Zhang Y, Bulitta JB, Moirano S, Jones A, Borgen J, Onsager A, Thaiwong T, Vail DM.
Vet. Comp. Oncol., 2024, 22, 410-421.
Abstract
Pharmacokinetics and tolerability of single-dose enteral cannabidiol and cannabidiolic acid rich hemp in horses (Equus caballus).
Thomson ACS, McCarrel TM, Zakharov A, Gomez B, Lyubimov A, Schwark WS, Mallicote MF, Portela DA, Bisiau AL, Wakshlag JJ.
Front. Vet. Sci., 2024, 11, 1356463.
Full article
Broad-spectrum and sensitive screening of more than 1000 compounds in equine urine using liquid chromatography/highresolution mass spectrometry.
Uchida T, Kisugi T, Ishii H, Yamada M, Kinoshita K, Leung GNW.
Rapid Commun. Mass Spectrom., 2024, 38, e9856.
Abstract
Exploring methandienone metabolites generated via homogenized camel liver: Advancements for anti-doping applications through high resolution-liquid chromatography mass spectrometry analysis.
Vazhat RA, Farook NAM, Nalakath J, Komathu PO.
Rapid Commun. Mass Spectrom., 2024, 38, e9902.
Abstract
Presence and detection of endogenous steroids in the horse—A review.
Viljanto M, Gray B, Scarth J.
Drug Test. Anal., 2024, 16, 1044-1065.
Abstract
Detection of boldenone in the urine of female horses-ex vivo formation versus administration.
Viljanto M, Kaabia Z, Taylor P, Hincks P, Muir T, Habershon-Butcher J, Bailly-Chouriberry L, Scarth J.
Drug Test. Anal., 2024, 16, 112-126.
Abstract
Detection of methandienone and its metabolites in equine urine, plasma and hair following a multidose oral administration.
Viljanto M, Love C, White D, Habershon-Butcher J, Hincks P, Gray B, Scarth J.
Drug Test. Anal., 2024, 16, 1203-1218.
Abstract
A rapid, sensitive, and high-throughput method for the simultaneous determination of antihypertensive drug combinations in dog plasma by UHPLC-MS/MS: The assessment of predicable bioequivalence of in-vitro dissolution condition.
Wang Y, Wang R, Wang H, Liu R, Bi K, Li Q.
Curr. Pharm. Des., 2024, 30, 2574-2585.
Abstract
Herb-drug interactions of silybinin and cilofexor in beagle dogs based on pharmacokinetics by UPLC-MS/MS.
Wei X, Su Y, Cheng Q, Liang S, Zhang T, Duan L, Shen X, Qiu X.
Front. Pharmacol., 2024, 15, 1334402.
Abstract
Effect of clodronate on gene expression in the peripheral blood of horses.
Wilcox CV, Knych HK, Katzman SA, Arthur RM, Rodriguez V, Finno CJ.
J. Vet. Pharmacol. Ther., 2024, 47, 187-192.
Abstract
PCR-based equine gene doping test for the Australian horseracing industry.
Wilkin T, Hamilton NA, Cawley AT, Bhat S, Baoutina A.
Int. J. Mol. Sci., 2024, 25, 2570.
Full article
Pharmacokinetics of a continuous intravenous infusion of hydromorphone in healthy dogs.
Wimbish C, Lynch AM, Knych HK, Ueda Y, Messenger KM.
Front. Vet. Sci., 2024, 11, 1362730.
Full article
Screening and confirmation of recombinant human follistatin in equine plasma for doping control purposes.
Wong KS, Cheung HW, Choi YC, To NS, Wan TSM, Ho ENM.
Drug Test. Anal., 2024, 16, 259-267.
Abstract
Gene doping control analysis of human erythropoietin transgene in equine plasma by PCR-liquid chromatography high-resolution tandem mass spectrometry.
Yuen BP, Wong KS, So YM, Kwok WH, Cheung HW, Wan TSM, Ho EN, Wong WT.
Anal. Chem., 2024, 96, 5307-5314.
Abstract
Application of newly developed and validated UPLC-MS/MS method for pharmacokinetic study of ROS1/NTRK inhibitor taletrectinib in beagle dog plasma.
Zhu Y, Wang F, Wang X, Cheng Y, Wang X, Fan A, Chang J.
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 2024, 1247, 124305.
Abstract
