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2016 Articles

Plasma and serum concentrations of cytarabine administered via continuous intravenous infusion to dogs with meningoencephalomyelitis of unknown etiology.
Early PJ, Crook KI, Williams LM, Davis EG, Muñana KR, Papich MG, Messenger KM.
J. Vet. Pharmacol. Ther., doi 10.1111/jvp.12360.

Quantification of furosemide in camel plasma by high resolution mass spectrometry, application on pharmacokinetics.
Wasfi IA, Wajid SA, Agha BA, Kamel AM, Al Biriki NA, Al Neaimi KM, Al Ali WA.
Biomed. Chromatogr., doi 10.1002/bmc.3902.

Rapid isolation and detection of erythropoietin in blood plasma by magnetic core gold nanoparticles and portable Raman spectroscopy.
Agoston R, Izake EL, Sivanesan A, Lott WB, Sillence M, Steel R.
Nanomedicine, 2016, 12, 633–641.

Drug residues after intravenous anesthesia and intrathecal lidocaine hydrochloride euthanasia in horses.
Aleman M, Davis E, Knych H, Guedes A, Smith F, Madigan JE.
J. Vet. Intern. Med., 2016, 30, 1322–1326.

The pharmacokinetics of pimobendan enantiomers after oral and intravenous administration of racemate pimobendan formulations in healthy dogs.
Bell T, Devi JL, Chiu S, Zahra P, Whittem T.
J. Vet. Pharmacol. Ther., 2016, 39, 54–61.

Blood concentrations of remifentanil during and after infusion in horses anesthetized with isoflurane and dexmedetomidine.
Benmansour P, Billinsky J, Duke-Novakovski T, Alcorn J.
Res. Vet. Sci., 2016, 107, 202–206.

Pharmacokinetics of ketorolac tromethamine in horses after intravenous, intramuscular, and oral single-dose administration.
Bianco AW, Constable PD, Cooper BR, Taylor SD.
J. Vet. Pharmacol. Ther., 2016, 39, 167–175.

A cluster of trace-concentration methamphetamine identifications in racehorses associated with a methamphetamine-contaminated horse trailer: A report and analysis.
Brewer K, Shults TF, Machin J, Kudrimoti S, Eisenberg RL, Hartman P, Wang C, Fenger C, Beaumier P, Tobin T.
Can. Vet. J., 2016, 57, 860–864.

Pharmacokinetics of intravenously and orally administered sotalol hydrochloride in horses and effects on surface electrocardiogram and left ventricular systolic function.
Broux B, De Clercq D, Decloedt A, De Baere S, Devreese M, Van Der Vekens N, Ven S, Croubels S, van Loon G.
Vet. J., 2016, 208, 60–64.

Detection and metabolic investigations of a novel designer steroid: 3-chloro-17α-methyl-5α-androstan-17β-ol.
Cawley AT, Blakey K, Waller CC, McLeod MD, Boyd S, Heather A, McGrath KC, Handelsman DJ, Willis AC.
Drug Test. Anal., 2016, 8, 621–632.

Detection of the selective androgen receptor modulator andarine (S-4) in a routine equine blood doping control sample.
Cawley AT, Smart C, Greer C, Lau ML, Keledjian J.
Drug Test. Anal., 2016, 8, 257–261.

Targeted metabolomics approach to detect the misuse of steroidal aromatase inhibitors in equine sports by biomarkers profiling.
Chan GH, Ho EN, Leung DK, Wong KS, Wan TS.
Anal. Chem., 2016, 88, 764–72.

Dextromethorphan and debrisoquine metabolism and polymorphism of the gene for cytochrome P450 isozyme 2D50 in Thoroughbreds.
Corado CR, McKemie DS, Knych HK.
Am. J. Vet. Res., 2016, 77, 1029–1035.

Mouldy feed: A possible explanation for the excretion of anabolic-androgenic steroids in horses.
Decloedt AI, Bailly-Chouriberry L, Vanden Bussche J, Garcia P, Popot MA, Bonnaire Y, Vanhaecke L.
Drug Test Anal., 2016, 8, 525–534.

An LC-MS/MS method for the determination of budesonide and 16α-hydroxyprednisolone in dog plasma.
Gazzotti T, Barbarossa A, Zironi E, Roncada P, Pietra M, Pagliuca G.
MethodsX., 2016, 24, 139–143.

Disposition of firocoxib in late pregnant and early postpartum mares.
Giguère S, Macpherson ML, Benson SM, Cox S, McNaughten JW. Pozor MA.
J. Vet. Pharmacol. Ther., 2016, 39, 196–198.

Pharmacokinetics and disposition of flupirtine in the horse.
Giorgi M, De Vito V, Poapolathep A, Rychshanova R, Sgorbini M, Owen H.
Vet. J., 2016, 208, 76–80.

Investigation of the selective androgen receptor modulators S1, S4 and S22 and their metabolites in equine plasma using high-resolution mass spectrometry.
Hansson A, Knych H, Stanley S, Thevis M, Bondesson U, Hedeland M.
Rapid Commun. Mass Spectrom., 2016, 30, 833–842.

Responses to commentary on paper: “Controlling the misuse of cobalt in horses”.
Ho ENM, Curl P, Sykes D, Wan TSM.
Drug Test. Anal., 2016, 8, 882–884.

Serum concentration of ketamine and antinociceptive effects of ketamine and ketamine-lidocaine infusions in conscious dogs.
Kaka U, Saifullah B, Abubakar AA, Goh YM, Fakurazi S, Kaka A, Behan AA, Ebrahimi M, Chen HC.
BMC Vet. Res., 2016, 9, 198.

Towards the elimination of excessive cobalt supplementation in racing horses: a pharmacological review.
Kinobe RT.
Res. Vet. Sci., 2016, 104, 106–112.

Disposition of isoflupredone acetate in plasma, urine and synovial fluid following intra-articular administration to exercised Thoroughbred horses.
Knych HK, Harrison LM, White A, McKemie DS.
Drug Test. Anal., 2016, 8, 142–148.

Pharmacokinetics of guaifenesin following administration of multiple doses to exercised thoroughbred horses.
Knych HK, Stanley SD, Benson D, Arthur RM.
J. Vet. Pharmacol. Ther., 2016, 39, 416–419.

Pharmacokinetics of methocarbamol and phenylbutazone in exercised Thoroughbred horses.
Knych HK, Stanley SD, Seminoff KN, McKemie DS, Kass PH.
J. Vet. Pharmacol. Ther., 2016, 39, 469–477.

Pharmacokinetics and pharmacodynamics of oral acetaminophen in combination with codeine in healthy Greyhound dogs.
KuKanich B.
J. Vet. Pharmacol. Ther., 2016, 39, 514–517.

Pharmacokinetics of procaterol in thoroughbred horses.
Kusano K, Nomura M, Toju K, Ishikawa Y, Minamijima Y, Yamashita S, Nagata S.
J. Vet. Pharmacol. Ther., 2016, 39, 264–270.

Doping control analysis of 46 polar drugs in horse plasma and urine using a 'dilute-and-shoot' ultra high performance liquid chromatography-high resolution mass spectrometry approach.
Kwok WH, Choi TL, Kwok KY, Chan GH, Wong JK, Wan TS.
J. Chromatogr. A, 2016, 1451, 41–49.

The detection of a synthetic interleukin-1 receptor antagonist peptide in a seized product from a racing stable.
Levina V, Timms M, Vine J, Steel R.
Drug Test. Anal., 2016, 8, 957–965.

Long-term monitoring of opioid, sedative and anti-inflammatory drugs in horse hair using a selective and sensitive LC-MS/MS procedure.
Madry MM, Spycher BS, Kupper J, Fuerst A, Baumgartner MR, Kraemer T, Naegeli H.
BMC Vet. Res., 2016, 12, 84.

Pharmacokinetics of intra-articular betamethasone sodium phosphate and betamethasone acetate and endogenous hydrocortisone suppression in exercising horses.
Menendez MI, Phelps MA, Bertone AL.
J. Vet. Pharmacol. Ther., 2016, 39, 22–26.

Pharmacokinetics of detomidine following intravenous or oral-transmucosal administration and sedative effects of the oral-transmucosal treatment in dogs.
Messenger KM, Hopfensperger M, Knych HK, Papich MG.
Am. J. Vet. Res., 2016, 77, 413-420.

Carprofen pharmacokinetics in plasma and in control and inflamed canine tissue fluid using in vivo ultrafiltration.
Messenger KM, Wofford JA, Papich MG.
J. Vet. Pharmacol. Ther., 2016, 39, 32–39.

Pharmacokinetics of zonisamide following rectal administration to healthy dogs.
Michaels JR, Hodshon AJ, Thomas WB, Boothe DM, Williams L.
Am. J. Vet. Res., 2016, 77, 1374–1380.

Characterization of equine cytochrome P450: role of CYP3A in the metabolism of diazepam.
Nakayama SM, Ikenaka Y, Hayami A, Mizukawa H, Darwish WS, Watanabe KP, Kawai YK, Ishizuka M.
J. Vet. Pharmacol. Ther., 2016, 39, 478–487.

Pharmacokinetics of centhaquin citrate in a dog model.
O'Donnell JN, O'Donnell EP, Kumar EJ, Lavhale MS, Andurkar SV, Gulati A, Scheetz MH.
J. Pharm. Pharmacol., 2016, 68, 803–809.

A pharmacokinetic/pharmacodynamic model capturing the time course of torasemide-induced diuresis in the dog.
Paulin A, Schneider M, Dron F, Woehrlé F.
J. Vet. Pharmacol. Ther., 2016, 39, 547–559.

Development of a new benazepril hydrochloride chewable tablet and evaluation of its bioequivalence for treatment of heart failure in dogs.
Qian M, Chen T, Zhou D, Zhang Z, Zhang Q, Tang S, Xiao X.
J. Vet. Pharmacol. Ther., 2016, 39, 98–101.

Pharmacokinetic comparison of oral tablet and suspension formulations of grapiprant, a novel therapeutic for the pain and inflammation of osteoarthritis in dogs.
Rausch-Derra LC, Rhodes L, Freshwater L, Hawks R.
J. Vet. Pharmacol. Ther., 2016, 39, 566–571.

The pharmacokinetics of DPH after the administration of a single intravenous or intramuscular dose in healthy dogs.
Sanchez A, Valverde A, Sinclair M, Mosley C, Singh A, Mutsaers AJ, Hanna B, Gu Y, Johnson R.
J. Vet. Pharmacol. Ther., 2016, 39, 452–459.

Equine hepatocytes: isolation, cryopreservation, and applications to in vitro drug metabolism studies.
Shibany KA, Tötemeyer S, Pratt SL, Paine SW.
Pharmacol. Res. Perspect., 2016, 4, e00268.

Pharmacokinetics and bioequivalence testing of five commercial formulations of omeprazole in the horse.
Sykes BW, Underwood C, Greer R, McGowan CM, Mills PC.
J. Vet. Pharmacol. Ther., 2016, 39, 78–83.

In vitro metabolism of l-corydalmine, a potent analgesic drug, in human, cynomolgus monkey, beagle dog, rat and mouse liver microsomes.
Tang X, Di X1, Zhong Z, Xie Q, Chen Y, Wang F, Ling Z, Xu P, Zhao K, Wang Z, Liu L, Liu X.
J. Pharm. Biomed. Anal., 2016, 128, 98–105.

Identification of recombinant human EPO variants in greyhound plasma and urine by ELISA, LC-MS/MS and western blotting: a comparative study.
Timms M, Steel R, Vine J.
Drug Test. Anal., 2016, 8, 164–176.

The metabolism of the dual endothelin receptor antagonist macitentan in rat and dog.
Treiber A, Miraval T, Bolli MH, Funel JA, Segrestaa J, Seeland S.
Xenobiotica, 2016, 46, 253–267.

Generation of phase II in vitro metabolites using homogenized horse liver.
Wong JKY, Chan GHM, Leung DKK, Tang FPW, Wan TSM.
Drug Test. Anal., 2016, 8, 241–247.

Simultaneous detection of recombinant growth hormones in equine plasma by liquid chromatography/high-resolution tandem mass spectrometry for doping control.
Wong KS, Chan GH, Ho EN, Wan TS.
J. Chromatogr. A, 2016, 1478, 35–42.

Pharmacokinetics and cardiovascular effects following a single oral administration of a nonaqueous pimobendan solution in healthy dogs.
Yata M, McLachlan AJ, Foster DJR, Page SW, Beijerink NJ.
J. Vet. Pharmacol. Ther., 2016, 39, 45–43.