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2018 Articles

The pharmacokinetics study of ginkgolide A, B and the effect of food on bioavailability after oral administration of ginkgolide extracts in beagle dogs.
Aa L, Fei F, Tan Z, Aa J, Wang G, Liu C.
Biomed. Chromatogr., 2018, 32, e4212.

Pharmacokinetic and pharmacodynamic properties of orally administered torsemide in healthy horses.
Agne GF, Jung SW, Wooldridge AA, Duran SH, Ravis W, Toribio R.
J. Vet. Intern. Med., 2018, 32, 1428–1435.

Pharmacokinetics of single-dose sildenafil administered orally in clinically healthy dogs: effect of feeding and dose proportionality.
Akabane R, Sato T, Sakatani A, Miyagawa Y, Tazaki H, Takemura N.
J. Vet Pharmacol. Ther., 2018, 41, 457‐462.

Pharmacokinetic evaluation of novel midazolam gel formulations following buccal administration to healthy dogs.
Aldawsari MF, Lau VW, Babu RJ, Arnold RD, Platt SR.
Am. J. Vet. Res., 2018, 79, 73–82.

Use of split-free nLC-MS/HRMS interface to improve the detection of α-cobratoxin in equine plasma for doping control.
Bailly-Chouriberry L, Garcia P, Cormant F, Loup B, Popot MA, Bonnaire Y.
Drug Test. Anal., 2018, 10, 880885.

The pharmacokinetics and analgesic effects of extended-release buprenorphine administered subcutaneously in healthy dogs.
Barletta M, Ostenkamp SM, Taylor AC, Quandt J, Lascelles BDX, Messenger KM.
J. Vet. Pharmacol. Ther., 2018, 41, 502–512.

In vitro anti-LPS dose determination of ketorolac tromethamine and in vivo safety of repeated dosing in healthy horses.
Bianco AW, Moore GE, Cooper BR, Taylor SD.
J. Vet. Pharmacol. Ther., 2018, 41, 98–104.

Pharmacokinetics and electrophysiological effects of sotalol hydrochloride in horses.
Broux B, De Clercq D, Decloedt A, Vera L, Devreese M, Gehring R, Croubels S, van Loon G.
Equine Vet. J., 2018, 50, 377–383.

Disposition of levetiracetam in healthy adult horses.
Cesar FB, Stewart AJ, Boothe DM, Ravis WR, Duran SH, Wooldridge AA.
Vet. Pharmacol. Ther., 2018, 41, 92–97.

LC-ESI-MS/MS determination of 4-methylpyrazole in dog plasma and its application to a pharmacokinetic study in dogs.
Chandrasekhar DV, S SP, Dittakavi S, Hiremath RA, Bhamidipati RK, Richter W, Srinivas NR, Mullangi R.
Biomed. Chromatogr., 2018, 32, e4065.

Metabolic study of methylstenbolone in horses using liquid chromatography-high resolution mass spectrometry and gas chromatography-mass spectrometry.
Choi TLS, Wong JKY, Kwok WH, Curl P, Mechie S, Wan TSM.
J. Chromatogr. A, 2018, 1546, 106–118.

Pharmacokinetics, pharmacodynamics and clinical use of trazodone and its active metabolite m-chlorophenylpiperazine in the horse.
Davis JL, Schirmer J, Medlin E.
J. Vet Pharmacol. Ther., 2018, 41, 393–401.

Determination of testosterone esters in the hair of male greyhound dogs using liquid chromatography high resolution mass spectrometry.
Devi JL, Zahra P, Vine JH, Whittem T.
Drug Test. Anal., 2018, 10, 460–473.

Efficacy, chondrotoxicity and plasma concentrations of tramadol following intra-articular administration in horses undergoing arthroscopy: preliminary findings.
Di Salvo A, Chiaradia E, Della Rocca G, Giorgi M, Mancini F, Marenzoni ML, Conti MB, Nannarone S.
Vet. Q., 2018, 38, 129–137.

Postoperative pharmacokinetics of meloxicam in horses after surgery for colic syndrome.
Di Salvo A, Giorgo M, Nannarone S, Lee HK, Corsalini J, della Rocca G.
J. Vet. Pharmacol. Ther., 2018, 41, 369–373.

Determination of human insulin in dog plasma by a selective liquid chromatography-tandem mass spectrometry method: Application to a pharmacokinetic study.
Dong S, Zeng Y, Wei G, Si D, Liu C.
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 2018, 1077-1078, 85–91.

The construction and application of a population physiologically based pharmacokinetic model for methadone in Beagles and Greyhounds.
Elwell‐Cuddy T, Li M, KuKanich B, Lin Z.
J. Vet. Pharmacol. Ther., 2018, 41, 670–683.

Gut microbiota-regulated pharmacokinetics of berberine and active metabolites in Beagle dogs after oral administration.
Feng R, Zhao ZX, Ma SR, Guo F, Wang Y, Jiang JD.
Front. Pharmacol., 2018, 9, 214.

Effects of three infusion fluids with different sodium chloride contents on steady‐state serum concentrations of bromide in dogs.
Fukunaga K, Matsumoto H, Wate M, Misawa K, Saito M, Matsuda H, Orito K.
J. Vet. Pharmacol. Ther., 2018, 41, 684–690.

Pharmacokinetic profiles of the active metamizole metabolites after four different routes of administration in healthy dogs.
Giorgi M, Łebkowska-Wieruszewska B, Lisowski A, Owen H, Poapolathep A, Kim TW, De Vito V.
J. Vet Pharmacol. Ther., 2018, 41, 428–436.

Detection of prohibited substances in equine hair by ultra-high performance liquid chromatography-triple quadrupole mass spectrometry – application to doping control samples.
Gray B, Viljanto M, Menzies E, Vanhaecke L.
Drug Test. Anal., 2018, 10, 1050–1060.

Detection and confirmation of α-cobratoxin in equine plasma by solid-phase extraction and liquid chromatography coupled to mass spectrometry.
Guan F, You Y, Li X, Robinson MA.
J. Chromatogr. A, 2018, 1533, 38–48.

Bioavailability and tolerability of nebulised dexamethasone sodium phosphate in adult horses.
Haspel AD, Giguère S, Hart KA, Berghaus LJ, Davis JL.
Equine Vet. J., 2018, 50, 85–90.

Pharmacokinetics of inorganic cobalt and a vitamin B12 supplement in the Thoroughbred horse: differentiating cobalt abuse from supplementation.
Hillyer LL, Ridd Z, Fenwick S, Hincks P, Paine SW.
Equine Vet. J., 2018, 50, 343–349.

Accurate determination of a novel vasodilatory β-blocker TJ0711 using LC-MS/MS: resolution of an isobaric metabolite interference in dog plasma.
Hu Y, Zhu W, Guan Y, Wu S, Zhang X, Li G, Si L, Huang J.
Biomed. Chromatogr., 2018, 32, e4196.

Pharmacokinetics and safety of oral glyburide in dogs with acute spinal cord injury.
Jeffery N, Boudreau CE, Konarik M, Mays T, Fajt V.
PeerJ, 2018, 6, e4387.

Mass spectrometric method for distinguishing isomers of dexamethasone via fragment mass ratio: An HRMS approach.
Karatt TK, Nalakath J, Perwad Z, Albert PH, Karakka Kal AK, Padusha MSA, Laya S.
J. Mass Spectrom., 2018, 53, 1046–1058.

Separation and identification of the epimeric doping agents - dexamethasone and betamethasone in equine urine and plasma: A reversed phase chiral chromatographic approach.
Karatt TK, Sayed R, Nalakath J, Perwad Z, Albert PH, Karakka Kal AK.
Steroids, 2018, 140, 77–82.

Enhanced bioavailability of tadalafil after intranasal administration in beagle dogs.
Kim JS, Kim MS, Baek IH.
Pharmaceutics, 2018, 10, 187.

Analysis of loxoprofen in tablets, patches and equine urine as tert-butyldimethylsilyl derivative by gas chromatography-mass spectrometry.
Kim Y, Seo C, Oh S, Kwak J, Jung S, Sin E, Kim H, Ji M, Lee HS, Park HJ, Lee G, Yu J, Kim M, Lee W, Paik MJ.
Arch. Pharm. Res., 2018, 41, 459–466.

L‐ and D‐threo ethylphenidate concentrations, pharmacokinetics, and pharmacodynamics in horses.
Knych HK, McKemie DS, Seminoff K, Hartmann P, Hovda L, Benson D.
Drug Test. Anal., 2018, 10, 1508–1517.

Detection and pharmacokinetics of grapiprant following oral administration to exercised Thoroughbred horses.
Knych HK, Seminoff K, McKemie DS.
Drug Test. Anal., 2018, 10, 1237–1243.

Pharmacokinetics, pharmacodynamics, and metabolism of acepromazine following intravenous, oral, and sublingual administration to exercised Thoroughbred horses.
Knych HK, Seminoff K, McKemie DS, Kass PH.
J. Vet. Pharmacol. Ther., 2018, 41, 522–535.

Pharmacokinetics of furosemide administered 4 and 24 hours prior to high-speed exercise in horses.
Knych HK, Vale A, Wilson WD, Kass PH, Arthur RM, Jones JH.
J. Vet. Pharmacol. Ther., 2018, 41, 224–229.

Pharmacogenetics of opioid analgesics in dogs.
Kongara K.
J. Vet. Pharmacol. Ther., 2018, 41, 195–204.

Pharmacokinetic profiles of 5 mg/kg ibudilast, a phosphodiesterase inhibitor, orally administered to dogs in fasted and non-fasted states. A preliminary study.
Łebkowska-Wieruszewska B, De Vito V, Kowalski CJ, Owen H, Poapolathep A, Lisowski A, Giorgi M.
Pol. J. Vet. Sci., 2018, 21, 281–285.

Determination of d-amphetamine and diphenhydramine in beagle dog plasma by a 96-well formatted liquid-liquid extraction and capillary zone electrophoresis with field-amplified sample stacking.
Li J, Zhang L, Cheng X, Zhang L, Shen B, Qing C, Fan G.
J. Pharm. Biomed. Anal., 2018, 156, 263–271.

A validated LC-MS/MS method for the determination of senkyunolide I in dog plasma and its application to a pharmacokinetic and bioavailability studies.
Li JQ, Wang JF, Li J, Zhang SH, He D, Tong RS, She SY.
Biomed. Chromatogr., 2018, 32, e4182.

A rapid analysis of piroxicam in beagle plasma applying evaporation-free liquid-liquid extraction by supercritical fluid chromatography-tandem mass spectrometry.
Li X, Gao Y, Liu J, Zhang G, Zhang T.
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 2018, 1100-1101, 93–99.

Metoclopramide nasal spray in vitro evaluation and in vivo pharmacokinetic studies in dogs.
Li Y, Fan X, Li W, Yang P, Zhang H, Tang D, Yin X, Sun J, Zheng A.
Pharm. Dev. Technol., 2018, 23, 275–281.

Quantitative determination of levonorgestrel in Beagle dog plasma after vaginal administration of intravaginal ring by high performance liquid chromatography-tandem mass spectrometry.
Liu Z, Qiu S, Gu Y, Ning M.
Biomed. Chromatogr., 2018, 32, e4367.

Pharmacokinetics of the anti-convulsant levetiracetam in neonatal foals.
MacDonald KD, Hart KA, Davis JL, Berghaus LJ, Giguère S.
Equine Vet. J., 2018, 50, 532–536.

Pharmacokinetics of intravenous lithium chloride and assessment of agreement between two methods of lithium concentration measurement in the horse.
Martin LM, Bukoski AD, Whelchel DD, Evans TJ, Wiedmeyer CE, Black SJ, Johnson PJ.
Equine Vet. J., 2018, 50, 537–543.

Quantification of doping compounds in faecal samples from racing pigeons, by liquid chromatography-tandem mass spectrometry.
Moreira FX, Silva R, André MB, de Pinho PG, Bastos ML, Ruivo J, Ruivo P, Carmo H.
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 2018, 1089, 33–42.

The pharmacokinetics of orally administered butylscopolamine in greyhound dogs.
Morris T, Paine SW, Viljanto M, Hudson S, Gower S, Pittorino M, Colgan S.
J. Vet. Pharmacol. Ther., 2018, 41, 790–794.

Impact of ABCB1 genotype in Collies on the pharmacokinetics of R‐ and S‐fexofenadine.
Myers MJ, Martinez M, Li F, Howard K, Yancy HF, Troutman L, Sharkey M.
J. Vet. Pharmacol. Ther., 2018, 41, 805–814.

The pharmacokinetics of cytarabine administered subcutaneously, combined with prednisone, in dogs with meningoencephalomyelitis of unknown etiology.
Pastina B, Early PJ, Bergman RL, Nettifee J, Maller A, Bray KY, Waldron RJ, Castel AM, Munana KR, Papich MG, Messenger KM.
Pharmacokinet. Report, 2018, 41, 638–l643.

Pharmacokinetics of tiludronate in horses: a field population study.
Popot MA, Jacobs M, Garcia P, Loup B, Guyonnet DJ, Toutain PL, Bailly-Chouriberry L, Bonnaire Y.
Equine Vet. J., 2018, 50, 488–492.

Pharmacokinetics of low-dose methotrexate in healthy Beagle dogs.
Rostang A, Mosca M, Jeannin M, Luissiez C, Berny P, Fourel I, Pin D, Prouillac C.
J. Vet. Pharmacol. Ther., 2018, 41, 659–669.

A novel and innovative hair test to determine glucocorticoid levels in racing camels for use in assessment of doping, health and disease.
Shah I, Haddow JD, Ibrahim HA, Sheikh MVA, Alhemeiri FSA.
Drug Test. Anal., 2018, 10, 742–749.

Bioavailability of suppository acetaminophen in healthy and hospitalized ill dogs.
Sikina ER, Bach JF, Lin Z, Gehring R, KuKanich B.
J. Vet. Pharmacol. Ther., 2018, 41, 652–658.

Pharmacokinetics, disposition, and plasma concentrations of dimethyl sulfoxide (DMSO) in the horse following topical, oral, and intravenous administration.
Soma LR, Robinson MA, You Y, Boston RC, Rudy J.
J. Vet Pharmacol. Ther., 2018, 41, 384–392.

Pharmacokinetics of intravenous, subcutaneous, and topical administration of lidocaine hydrochloride and metabolites 3-hydroxylidocaine, monoethylglycinexylidide, and 4-hydroxylidocaine in horse.
Soma LR, You Y, Robinson MA, Boston RC.
J. Vet. Pharmacol. Ther., 2018 41, 825–837.

Determination of a astragaloside IV derivative LS-102 in plasma by ultra-performance liquid chromatography-tandem mass spectrometry in dog plasma and its application in a pharmacokinetic study.
Sun WX, Zhang ZF, Xie J, He Y, Cheng Y, Ding LS, Luo P, Qing LS.
Phytomedicine, 2018, 53, 243–251.

Prediction of human pharmacokinetics of ulixertinib, a novel ERK1/2 inhibitor from mice, rats, and dogs pharmacokinetics.
Suresh PS, Jairam RK, Chandrasekhar DV, Vinod AB, Hiremath RA, Raj A, Zainuddin M, Bhamidipati RK, Mullangi R.
Eur. J. Drug Metab. Pharmacokinet., 2018, 43, 453–460.

Quantitative determination of meloxicam in dog plasma by high performance liquid chromatography-tandem mass spectrometry and its application in a pharmacokinetic study.
Tian Y, Wu X, Zhang M, Zhao L, Xiong Z, Qin F.
Biomed. Chromatogr., 2018, 32, e4228.

Detection of phosphorothioated (PS) oligonucleotides in horse plasma using a product ion (m/z 94.9362) derived from the PS moiety for doping control.
Tozaki T, Karasawa K, Minamijima Y, Ishii H, Kikuchi M, Kakoi H, Hirota KI, Kusano K, Nagata SI.
BMC Res. Notes, 2018, 11, 770.

Re-evaluation of the regulation of omeprazole in racehorses: An evidence-based approach.
Viljanto M, Hillyer L, Hincks P, Pearce C, Paine SW.
J. Vet. Pharmacol. Ther., 2018, 41, 469‐475.

Monitoring dehydroepiandrosterone (DHEA) in the urine of Thoroughbred geldings for doping control purposes.
Viljanto M, Hincks P, Hillyer L, Cawley A, Suann C, Noble G, Walker CJ, Parkin MC, Kicman AT, Scarth J.
Drug Test. Anal., 2018, 10, 1518–1527.

Evaluation of pharmacokinetic properties of vitacoxib in fasted and fed horses.
Wang J, Xue J, Kong J, Li J, Zhang S, Cao X.
J. Vet. Pharmacol. Ther., 2018, 41, 843–847.

Simultaneous determination and pharmacokinetics of peimine and peiminine in Beagle dog plasma by UPLC-MS/MS after the oral administration of Fritillariae ussuriensis Maxim and Fritillariae thunbergii Miq powder.
Wang Z, Cao F, Chen Y, Tang Z, Wang Z.
Molecules, 2018, 23, E1573.

A rapid and sensitive method for the quantitative analysis of ibuprofen and its metabolites in equine urine samples by gas chromatography with tandem mass spectrometry.
Waraksa E, Woźniak MK, Kłodzińska E, Wrzesień R, Bobrowska-Korczak B, Namieśnik J.
J. Sep. Sci., 2018, 41, 3881–3891.

Doping control analysis of 121 prohibited substances in equine hair by liquid chromatography-tandem mass spectrometry.
Wong JKY, Choi TLS, Kwok KY, Lei ENY, Wan TSM.
J. Pharm. Biomed. Anal., 2018, 158, 189–203.

Comparative single-dose pharmacokinetics of sildenafil after oral and rectal administration in healthy beagle dogs.
Yang HJ, Oh YI, Jeong JW, Song KH, Koo TS, Seo KW.
BMC Vet. Res., 2018, 14, 291.

Application of a sensitive and specific LC-ESI-MS/MS method for the simultaneous quantification of twelve bioactive components in dog plasma for an intravenous pharmacokinetic study of Yiqifumai Injection in Beagle dogs.
Zhang F, Qiao X, Lu H, Zhang S, Du W, Xiao X.
Biomed. Chromatogr., 2018, 32, e4256.