1. You are here:
  2. Research
  3. Research Articles
  4. 2019 Articles

2019 Articles

Pharmacokinetic study of sudaxine in dog plasma using novel LC/MS/MS method.
Altawallbeh G, Smith L, Lewis SJ, Authier S, Bujold K, Gaston B, Bederman I.
Drug Test. Anal., 2019, 11, 403–410.

Pharmacokinetics of harpagoside in horses after intragastric administration of a Devil's claw (Harpagophytum procumbens) extract.
Axmann S, Hummel K, Nöbauer K, Razzazi-Fazeli E, Zitterl-Eglseer K.
J. Vet. Pharmacol. Ther., 2019, 42, 37–44.

Pharmacokinetic modeling and simulation of etodolac following single oral administration in dogs.
Baek IH.
Xenobiotica, 2019, 49, 981–986.

Clinical and pharmacokinetic interactions between oral fluconazole and intravenous ketamine and midazolam in dogs.
Berke K, KuKanich B, Orchard R, Rankin D, Joo H.
Vet. Anaesth. Analg., 2019, 46, 745–752.

Pharmacokinetics of single doses of maropitant citrate in adult horses.
Berryhill EH, Knych H, Edman JM, Magdesian KG.
J. Vet. Pharmacol. Ther., 2019, 42, 487–491.

Thyroid hormone and thyrotropin concentrations and responses to thyrotropin-stimulating hormone in horses with PPID compared with age-matched normal horses.
Breuhaus BA.
J. Equine Vet. Sci., 2019, 75, 35–40.

A pharmacokinetic model optimized by covariates for propofol target-controlled infusion in dogs.
Cattai A, Bizzotto R, Cagnardi P, Di Cesare F, Franci P.
Vet. Anaesth. Analg., 2019, 46, 568–578.

Detection of erythropoiesis-stimulating agents (ESAs) in equine urine and blood by SAR-PAGE.
Cavalcanti RTC, Teixeira PAC, Levy RS, Pereira HMG, Aquino Neto FR.
Drug Test. Anal., 2019, 11, 772–781.

Pharmacokinetics of a modified, compounded theophylline product in dogs.
Cavett CL, Li Z, McKiernan BC, Reinhart JM.
J. Vet. Pharmacol. Ther., 2019, 42, 593–601.

Single-dose pharmacokinetics and preliminary safety assessment with use of CBD-rich hemp nutraceutical in healthy dogs and cats.
Deabold KA, Schwark WS, Wolf L, Wakshlag JJ.
Animals (Basel), 2019, 9, 832.

Clinical pharmacokinetics of a dexmedetomidine-methadone combination in dogs undergoing routine anaesthesia after buccal or intramuscular administration.
Di Cesare F, Gioeni D, Ravasio G, Pellegrini A, Lucatello L, Bisutti V, Villa R, Cagnardi P.
J. Vet. Pharmacol. Ther., 2019, 42, 392–400.

Diphenhydramine pharmacokinetics after oral and intravenous administration of diphenhydramine and oral administration of dimenhydrinate to healthy dogs, and pharmacodynamic effect on histamine-induced wheal formation: a pilot study.
Ehling S, Bäumer W, Papich MG.
Vet. Dermatol., 2019, 30, 91–e24.

Pharmacokinetics of intrarectal altrenogest in horses.
Ellis KE, Council-Troche RM, Von Dollen KA, Beachler TM, Bailey CS, Davis JL, Lyle SK.
J. Equine Vet. Sci., 2019, 72, 41–46.

Tamoxifen in horses: pharmacokinetics and safety study.
Gajardo G, López-Muñoz R, Plaza A, Uberti B, Sarmiento J, Morán G, Henríquez C.
Ir. Vet. J., 2019, 72, 5.

Pharmacokinetics and metabolism of H3B-6545, a selective estrogen receptor covalent antagonist, in dog plasma by liquid chromatography combined with electrospray ionization tandem mass spectrometry.
Ge Y, Zhang Y, Li X, Yu Y, Liu Q.
J. Pharm. Biomed. Anal., 2019, 172, 189–199.

Simultaneous quantitation of 9 anabolic and natural steroidal hormones in equine urine by UHPLC-MS/MS triple quadrupole.
Genangeli M, Caprioli G, Cortese M, Laus F, Petrelli R, Ricciutelli M, Sagratini G, Sartori S, Vittori S.
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 2019, 1117, 36–40.

Oral reserpine administration in horses results in low plasma concentrations that alter platelet biology.
Gilbertie JM, Davis JL, Davidson GS, McDonald AM, Schirmer JM, Schnabel LV.
Equine Vet. J., 2019, 51, 537–543.

Alfaxalone for total intravenous anaesthesia in horses.
Goodwin WA, Pasloske K, Keates HL, Ranasinghe MG, Woldeyohannes S, Perkins N.
Vet. Anaesth. Analg., 2019, 46, 188–199.

A possible solution to model nonlinearity in elimination and distributional clearances with α2‐adrenergic receptor agonists: Example of the intravenous detomidine and methadone combination in sedated horses.
Gozalo-Marcilla M, Moreira da Silva R, Pacca Loureiro Luna S, Rodrigues de Oliveira A, Werneck Fonseca M, Peporine Lopes N, Taylor PM, Pelligand L.
J. Vet. Pharmacol. Ther., 2019, 42, 738–744.

Pharmacokinetics and physiologic/behavioral effects of buprenorphine administered sublingually and intravenously to neonatal foals.
Grubb TL, Kurkowski D, Sellon DC, Seino KK, Coffey T, Davis JL.
J. Vet. Pharmacol. Ther., 2019, 42, 26–36.

A comprehensive approach to detecting multitudinous bioactive peptides in equine plasma and urine using hydrophilic interaction liquid chromatography coupled to high resolution mass spectrometry.
Guan F, You Y, Li X, Robinson MA.
Drug Test. Anal., 2019, 11, 1308–1325.

Plasma adrenocorticotropic hormone concentration in horses decreases after freezing for 60 days.
Haffner JC, Neal DL, Hoffman RM, Grubbs ST.
J. Vet. Diagn. Invest., 2019, 31, 856–858.

Pharmacokinetics and selected pharmacodynamics of morphine and its active metabolites in horses after intravenous administration of four doses.
Hamamoto-Hardman BD, Steffey EP, Weiner D, McKemie DS, Kass P, Knych HK.
J. Vet. Pharmacol. Ther., 2019, 42, 401–410.

Age related and seasonal changes of plasma concentrations of insulin-like peptide 3 and testosterone from birth to early-puberty in Thoroughbred male horses.
Hannan MA, Murase H, Sato F, Tsogtgerel M, Kawate N, Nambo Y.
Theriogenology, 2019, 132, 212–217.

Development and validation of a simple and sensitive high resolution LC/MS method for determination of PF-04620110 in dog plasma: application to the pharmacokinetic study.
He F, Zheng W, Chen Y, Mo C, Chen Y.
Biomed. Chromataogr., 2019, 33, e4562.

Identification of prototype compounds and derived metabolites of naoxintong capsule in Beagle dog urine and feces by UFLC-Q-TOF-MS/MS.
He Y, Su W, Chen T, Zeng X, Yan Z, Guo J, Yang W, Wu H.
J. Pharm. Biomed. Anal., 2019, 176, 112806.

Systematic analysis to assess the scientific validity of the international residue limits for caffeine and theophylline in horse-racing.
Hertzsch R, Richter A.
Vet. Rec., 2019, 185, 230.

Studies of pharmacokinetics in beagle dogs and drug-drug interaction potential of a novel selective ZAK inhibitor 3h for hypertrophic cardiomyopathy treatment.
Jiang W, Ding L, Dai T, Guo J, Dai R, Chang Y.
J. Pharm. Biomed. Anal., 2019, 172, 206–213.

The pharmacokinetics of cytarabine administered at three distinct subcutaneous dosing protocols in dogs with meningoencephalomyelitis of unknown origin.
Jones A, McGrath S, Gustafson DL.
J. Vet. Pharmacol. Ther., 2019, 42, 588–592.

Metabolism of scoparone in experimental animals and humans.
Juvonen RO, Novák F, Emmanouilidou E, Auriola S, Timonen J, Heikkinen AT, Küblbeck J, Finel M, Raunio H.
Planta Med., 2019, 85, 453–464.

Separation of ephedrine and pseudoephedrine enantiomers using a polysaccharide‐based chiral column: A normal phase liquid chromatography–high‐resolution mass spectrometry approach.
Karakka Kal AK, Karatt TK, Sayed R, Philip M, Meissir S, Nalakath J.
Chirality, 2019, 31, 568–574.

Use of polysaccharide-based chiral columns: enantiomeric separation of seven pairs of abused drugs by high-performance liquid chromatography–mass spectrometry.
Karatt TK, Karakka Kal AK, Sayed R, Nalakath J, Perwad Z.
Forensic Toxicol., 2019, 37, 254–260.

Use of gas chromatography-mass spectrometry for definitive diagnosis of synthetic cannabinoid toxicity in a dog.
Kelmer E, Shimshoni JA, Merbl Y, Kolski O, Klainbart S.
J. Vet. Emerg. Crit. Care (San Antonio), 2019, 29, 573–577.

Simultaneous quantification of tegoprazan and its major metabolite M1 in dog plasma using liquid chromatography-tandem mass spectrometry.
Kim J, Kim S, Noh HJ, Ryu SY, Kim SJ.
J. Pharm. Biomed. Anal., 2019, 171, 99–103.

Plasma steroid profiles before and after ACTH stimulation test in healthy horses.
Kirchmeier A, van Herwaarden AE, van der Kolk JH, Sauer FJ, Gerber V.
Domest. Anim. Endocrinol., 2019, 72, 106419.

Detection, pharmacokinetics, and selected pharmacodynamic effects of methamphetamine following a single transmucosal and intravenous administration to exercised Thoroughbred horses.
Knych HK, Arthur RM, Kanarr KL, McKemie DS, Kass PH.
Drug Test. Anal., 2019, 11, 1431–1443.

Pharmacokinetics of intravenous flumethasone and effects on plasma hydrocortisone concentrations and inflammatory mediators in the horse.
Knych HK, Arthur RM, McKemie DS, Baden R, Oldberg N, Kass PH.
Equine Vet. J., 2019, 51, 238–245.

Phenylbutazone blood and urine concentrations, pharmacokinetics, and effects on biomarkers of inflammation in horses following intravenous and oral administration of clinical doses.
Knych HK, Arthur RM, McKemie DS, Seminoff K, Hamamoto‐Hardman B, Kass PH.
Drug Test. Anal., 2019, 11, 792–803.

Plasma and synovial fluid concentrations and cartilage toxicity of bupivacaine following intra-articular administration of a liposomal formulation to horses.
Knych HK, Mama KR, Moore C, Hill AE, McKemie DS.
Equine Vet. J., 2019, 51, 408–414.

Pharmacokinetics of hydroxyzine and cetirizine following oral administration of hydroxyzine to exercised Thoroughbred horses.
Knych HK, Weiner D, Steinmetz S, Flynn K, McKemie DS.
J. Vet. Pharmacol. Ther., 2019, 42, 617–623.

Concentrations of indomethacin and its metabolite desmethylindomethacin in plasma and urine after repeated indomethacin topical application to Thoroughbreds.
Kusano K, Minamijima Y, Mashita S, Kunii H, Yamashita S, Nagata S.
Equine Vet. J., 2019, 51, 506–509.

Concentrations of sulphated estrone, estradiol and dehydroepiandrosterone measured by mass spectrometry in pregnant mares.
Legacki EL, Scholtz EL, Ball BA, Esteller-Vico A, Stanley SD, Conley AJ.
Equine Vet. J., 2019, 51, 802–808.

Enantioselective determination of ketamine in dog plasma by chiral liquid chromatography-tandem mass spectrometry.
Li R, Zhong K, Jiang J, Zhan Y, Chen X.
Biomed. Chromataogr., 2019, 33, e4578.

Pharmacokinetic characterizations of ginsenoside ocotillol, RT5 and F11, the promising agents for Alzheimer's disease from American ginseng, in rats and Beagle dogs.
Li Y, Hu H, Li Z, Li R, Xu F, Zhao C, An Y, Liu Y, Wang Z, Zhang B, Geng C.
Pharmacology, 2019, 104, 7–20.

Effect of heart rate on the pharmacokinetics of fentanyl in dogs anesthetized with isoflurane and hydromorphone.
Machado ML, Soares JH, Pypendop BH, Henao-Guerrero N, Pavlisko ND, Ross J.
Vet. Anaesth. Analg., 2019, 46, 736–744.

Variability in plasma concentrations of methylprednisolone six days after intrasynovial injection of methylprednisolone acetate in racing horses: A field study.
Machin J, Duer W, Maylin G, Fenger C, Wilson D, Ivey M, Berthold B, Allison S, Tobin T.
Equine Vet. J., 2019, 51, 343–348.

The use of feathers from racing pigeons for doping control purposes.
Moreira FX, Carmo H, Melo A, André MB, Silva R, Azevedo Z, Bastos ML, de Pinho PG.
J. Anal. Toxicol., 2019, 43, 307–315.

Plasma and urine pharmacokinetics of intravenously administered flunixin in greyhound dogs.
Morris T, Paine SW, Zahra P, Li E, Colgan S, Karamatic S.
J. Vet. Pharmacol. Ther., 2019, 42, 505–510.

Pharmacological regulation in the USA and pharmacokinetics parameters of firocoxib, a highly selective Cox-2, by pain management in horses.
Rangel-Nava A, Ramírez-Uribe JM, Recillas-Morales S, Ibancovichi-Camarillo JA, Venebra-Muñoz A, Sánchez-Aparicio P.
J. Equine Vet. Sci., 2019, 77, 36–42.

Ultrahigh-performance liquid chromatography with tandem mass spectrometry for the determination of 10 alkaloids in Beagle plasma after the oral administration of the three Coptidis rhizoma extracts.
Ren Y, Wang Z, Wu C, Dong H, Gan C, Fan L, Wang W, Yang C.
J. Ethnopharmacol., 2019, 239, 111896.

Evaluation of methadone concentrations in bitches and in umbilical cords after epidural or systemic administration for caesarean section: a randomized trial.
Romagnoli N, Barbarossa A, Cunto M, Ballotta G, Zambelli D, Armorini S, Zaghini A, Lambertini C.
Vet. Anaesth. Analg., 2019, 46, 375–383.

Effect of feeding on the pharmacokinetics of vilazodone in dogs.
Sartini I, Gbylik-Sikorska M, Łebkowska-Wieruszewska B, Gajda A, Lisowski A, Kowalski CJ, Posyniak A, Poapolathep A, Giorgi M.
Res. Vet. Scil., 2019, 125, 309–314.

Bioactive indanes: Development and validation of an LC-MS/MS bioanalytical method for the determination of PH46A, a new potential anti-inflammatory agent, in dog and rat plasma and its application to a pharmacokinetic study in dog.
Scalabrino GA, Zhang T, Frankish N, Sheridan H.
J. Pharm. Biomed. Anal., 2019, 179, 113011.

Ionized magnesium and calcium concentration and their ratio in equine plasma samples as determined by a regulatory laboratory compared to a clinical reference laboratory.
Schumacher SA, Yardley J, Bertone AL.
Drug Test. Anal., 2019, 11, 455–460.

Tear fluid pharmacokinetics following oral prednisone administration in dogs with and without conjunctivitis.
Sebbag L, Yan Y, Smith JS, Allbaugh RA, Wulf LW, Mochel JP.
J. Ocul. Pharmacol. Ther., 2019, 35, 341–349.

Development, validation of LC-MS/MS method and determination of pharmacokinetic parameters of the stroke neuroprotectant neurounina-1 in Beagle dog plasma after intravenous administration.
Severino B, Corvino A, Fiorino F, Frecentese F, Perissutti E, Caliendo G, Santagada V, Magli E, Molinaro P, Pignataro G, Annunziato L, Antunes NJ, Rojas-Moscoso J, de Freitas NL, Mendes GD, De Nucci G.
Front. Pharmacol., 2019, 10, 432.

Pharmacokinetics and intraocular pressure-lowering activity of TAK-639, a novel C-type natriuretic peptide analog, in rabbit, dog, and monkey.
Savinainen A, Prusakiewicz JJ, Oswald J, Spencer E, Lou Z, Cohen ML, Rashidzadeh H, Josiah S.
Exp. Eye Res., 2019, 189, 107836.

Metabolism and elimination of the catechol O-methyltransferase inhibitor tolcapone in the horse.
Stanley S, Van den Berg K, Foo HC, Deng D.
Drug Test. Anal., 2019, 11, 578–585.

Tracking main environmental factors masking a minor steroidal doping effect using metabolomic analysis of horse urine by liquid chromatography-high-resolution mass spectrometry.
Stojiljkovic N, Leroux F, Bubanj S, Popot MA, Paris A, Tabet JC, Junot C.
Eur. J. Mass Spectrom. (Chichester), 2019, 25, 339–353.

Pharmacokinetics, metabolism and excretion of celecoxib, a selective cyclooxygenase-2 inhibitor, in horses.
Subhahar MB, Singh J, Albert PH, Kadry AM.
J. Vet. Pharmacol. Ther., 2019, 42, 518–524.

Pilot study to quantify the time to clear dexamethasone from plasma and urine of adult horses following a single nebulisation.
Symonds NE, Dart AJ, Keledjian J, Lau ML, Ennis LC, McIver VC, Tsang AS, Biasutti SA, Jeffcott LB.
Aust. Vet. J., 2019, 97, 144–148.

Effects of vatinoxan on cardiorespiratory function, fecal output and plasma drug concentrations in horses anesthetized with isoflurane and infusion of medetomidine.
Tapio HA, Raekallio MR, Mykkänen AK, Al-Ramahi D, Scheinin M, Hautajärvi HJ, Männikkö S, Vainio O.
Vet. J., 2019, 251, 105345.

An immuno polymerase chain reaction screen for the detection of CJC‐1295 and other growth‐hormone‐releasing hormone analogs in equine plasma.
Timms M, Ganio K, Forbes G, Bailey S, Steel R.
Drug Test. Anal., 2019, 11, 804–812.

A method for confirming CJC‐1295 abuse in equine plasma samples by LC–MS/MS.
Timms M, Ganio K, Steel R.
Drug Test. Anal., 2019, 11, 1248–1257.

Droplet digital PCR detection of the erythropoietin transgene from horse plasma and urine for gene-doping control.
Tozaki T, Ohnuma A, Takasu M, Kikuchi M, Kakoi H, Hirota KI, Kusano K, Nagata SI.
Genes (Basel), 2019, 10, 243.

Identification of metabolomic changes in horse plasma after racing by liquid chromatography-high resolution mass spectrometry as a strategy for doping testing.
Ueda T, Tozaki T, Nozawa S, Kinoshita K, Gawahara H.
J. Equine Sci., 2019, 30, 55–61.

Elucidation of the biosynthetic pathways of boldenone in the equine testis.
Viljanto MJ, Kicman AT, Walker CJ, Parkin MC, Wolff K, Pearce CM, Scarth J.
Steroids, 2019, 146, 79–91.

Pharmacokinetics of furosemide in thoroughbred horses subjected to supramaximal treadmill exercise with and without controlled access to water.
Villarino NF, Lopez CM, Sams RA, Bayly WM.
BMC Vet. Res., 2019, 15, 275.

Pharmacokinetics and pharmacodynamics of intranasal and intravenous naloxone hydrochloride administration in healthy dogs.
Wahler BM, Lerche P, Ricco Pereira CH, Bednarski RM, KuKanich B, Lakritz J, Aarnes TK.
Am. J. Vet. Res., 2019, 80, 696–701.

Clinical pharmacokinetics and pharmacodynamics of intravenous alfaxalone in young Thoroughbred horses premedicated with medetomidine and midazolam.
Wakuno A, Aoki M, Kushiro A, Mae N, Maeda T, Yamazaki Y, Minamijima Y, Nagata SI, Ohta M.
Vet. Rec., 2019, 184, 411.

Simultaneous determination of idelalisib and its metabolite GS-563117 in dog plasma by LC-MS/MS: application to a pharmacokinetic study.
Wang C, Jia F, Zhang Y.
Biomed. Chromatogr., 2019, 33, e4511.

Nonlinear mixed‐effects pharmacokinetic modeling of the novel COX‐2 selective inhibitor vitacoxib in dogs.
Wang J, Schneider BK, Sun P, Gong X, Qiu J, Li J, Seo Y-J, Mochel JP, Cao X.
J. Vet. Pharmacol. Ther., 2019, 42, 530–540.

An LC-MS/MS method for quantification of HR011303, a novel highly selective urate transporter 1 inhibitor in Beagle dogs and the application to a pharmacokinetic study.
Wang J, Yao W, Fan D, Qiu Z, Song J, Pan K, Hang T.
Biomed. Chromatogr., 2019, 33, e4604.

A rapid and eco-friendly method for determination of the main components of gamma-oryzanol in equestrian dietary and nutritional supplements by liquid chromatography-Tandem mass spectrometry.
Waraksa E, Kowalski K, Kłodzińska E, Rola R, Ciekot J, Filipiak W, Bieńkowski T, Namieśnik J.
J. Pharm. Biomed. Anal., 2019, 172, 339–348.

Pharmacodynamics and pharmacokinetics of a new type of compound lansoprazole capsule in gastric ulcer rats and Beagle dogs: importance of adjusting oxidative stress and inflammation.
Wei B, Wang Y, Wu H, Liu M, Yao W, Wei M.
Pharmaceutics, 2019, 11, 49.

Cobalt accumulation in horses following repeated administration of cobalt chloride.
Wenzel RG, Major D, Hesp KF, Hall E, Doble P.
Aust. Vet. J., 2019, 97, 465–472.

Pharmacokinetics of cligosiban in dog plasma after oral administration by liquid chromatography electrospray ionization tandem mass spectrometry.
Xi W, Zou Q, Ouyang P.
Biomed. Chromatogr., 2019, 33, e4611.

Simultaneous determination of evobrutinib and its metabolite evobrutinib-diol in dog plasma by liquid chromatography combined with electrospray ionization tandem mass spectrometry.
Yang J, Yu H, Tang Q.
Biomed. Chromatogr., 2019, 33, e4575.

High-throughput doping control analysis of 28 amphetamine-type stimulants in equine plasma using hydrophilic interaction liquid chromatography-tandem mass spectrometry.
You Y, Guan F, D'Ippolito R, Li X, Soma LR, Robinson MA.
Drug Test. Anal., 2019, 11, 441–454.

Doping control analysis of four JWH-250 metabolites in equine urine by LC-MS/MS.
You Y, Proctor RM, Vasilko ED, Robinson MA.
Drug Test. Anal., 2019, 11, 649–658.

Evaluation of plasma concentration after intravenous and intramuscular penicillin administration over 24 hr in healthy adult horses.
Younkin JT, Santschi EM, Kukanich B, Lubbers BV, Warner M.
J. Vet. Pharmacol. Ther., 2019, 11, 38.

The chiral bioconversion and pharmacokinetic analysis of trelagliptin in Beagle dog plasma by LC-MS/MS.
Zhou L, Xi W, Zhang H, Sun L, Yu J, Zou Q.
J. Chromatogr. Sci., 2019, 58, 31–36.

Simultaneous quantitation of a novel α₁/β₁-blocker TJ0711 and its two metabolites in dog plasma using LC-MS/MS and its application to a pharmacokinetic study after intravenous infusion.
Zhu W, Liu W, Li H, Xu G, Li Q, Huang J, Li G, Si L.
Pharmaceutics, 2019, 42, 239–242.