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2019 Articles

Concentrations of medetomidine enantiomers and vatinoxan, an α2-adrenoceptor antagonist, in plasma and central nervous tissue after intravenous coadministration in dogs.
Honkavaara JM, Raekallio MR, Syrja PM, Pypendop BH, Knych HK, Kallio-Kujala IJ, Vainio OM.
Vet. Anaesth. Analg., DOI 10.1016/j.vaa.2019.07.004.

Administration study of recombinant human relaxin-2 in horse for doping control purpose.
Kwok WH, Choi TLS, Leung GNW, Wong ASY, Yue SK, Wan TSM, Ho ENM.
Drug Test. Anal., DOI 10.1002/dta.2732.

Plasma adrenocorticotropic hormone concentration in horses decreases after freezing for 60 days.
Haffner JC, Neal DL, Hoffman RM, Grubbs ST.
J. Vet. Diagn. Invest., DOI 10.1177/1040638719882374.

Bioformation of boldenone and related precursors/metabolites in equine faeces and urine, with relevance to doping control.
Viljanto M, Kicman AT, Walker CJ, Wolff K, Muir T, Hincks P, Biddle S, Scarth J.
Drug Test. Anal., DOI 10.1002/dta.2706.

Simultaneous determination of donepezil, 6-O-desmethyl donepezil and spinosin in beagle dog plasma using liquid chromatography‒tandem mass spectrometry and its application to a drug-drug interaction study.
Lee CB, Min JS, Chae SU, Kim HM, Jang JH, Jung IH, Zheng YF, Ryu JH, Bae SK.
J. Pharm. Biomed. Anal., DOI 10.1016/j.jpba.2019.112919.

Investigation of the metabolism of the selective androgen receptor modulator LGD-4033 in equine urine, plasma and hair following oral administration.
Cutler C, Viljanto M, Hincks P, Habershon-Butcher J, Muir T, Biddle S.
Drug Test. Anal., DOI 10.1002/dta.2719.

Re‐evaluation of the pharmacokinetics of xylazine administered to Thoroughbred horses.
Habershon‐Butcher J, Cutler C, Viljanto M, Hincks PR, Biddle S, Paine SW.
J. Vet. Pharmacol. Ther., DOI 10.1111/jvp.12820.

Pharmacokinetics and intraocular pressure-lowering activity of TAK-639, a novel C-type natriuretic peptide analog, in rabbit, dog, and monkey.
Savinainen A, Prusakiewicz JJ, Oswald J, Spencer E, Lou Z, Cohen ML, Rashidzadeh H, Josiah S.
Exp. Eye Res., DOI 10.1016/j.exer.2019.107836.

A possible solution to model nonlinearity in elimination and distributional clearances with α2‐adrenergic receptor agonists: Example of the intravenous detomidine and methadone combination in sedated horses.
Gozalo-Marcilla M, Moreira da Silva R, Pacca Loureiro Luna S, Rodrigues de Oliveira A, Werneck Fonseca M, Peporine Lopes N, Taylor PM, Pelligand L.
J. Vet. Pharmacol. Ther., DOI 10.1111/jvp.12815.

The pharmacokinetics of cytarabine administered at three distinct subcutaneous dosing protocols in dogs with meningoencephalomyelitis of unknown origin.
Jones A, McGrath S, Gustafson DL.
J. Vet. Pharmacol. Ther., DOI 10.1111/jvp.12809.

Clinical and pharmacokinetic interactions between oral fluconazole and intravenous ketamine and midazolam in dogs.
Berke K, KuKanich B, Orchard R, Rankin D, Joo H.
Vet. Anaesth. Analg., DOI 10.1016/j.vaa.2019.06.007.

Systematic analysis to assess the scientific validity of the international residue limits for caffeine and theophylline in horse-racing.
Hertzsch R, Richter A.
Vet. Rec., DOI 10.1136/vr.105404.

Cobalt accumulation in horses following repeated administration of cobalt chloride.
Wenzel RG, Major D, Hesp KF, Hall E, Doble P.
Aust. Vet. J., DOI 10.1111/avj.12872.

Effect of heart rate on the pharmacokinetics of fentanyl in dogs anesthetized with isoflurane and hydromorphone.
Machado ML, Soares JH, Pypendop BH, Henao-Guerrero N, Pavlisko ND, Ross J.
Vet. Anaesth. Analg., DOI 10.1016/j.vaa.2019.06.005.

A pharmacokinetic model optimized by covariates for propofol target-controlled infusion in dogs.
Cattai A, Bizzotto R, Cagnardi P, Di Cesare F, Franci P.
Vet. Anaesth. Analg., DOI 10.1016/j.vaa.2019.04.009.

Use of gas chromatography-mass spectrometry for definitive diagnosis of synthetic cannabinoid toxicity in a dog.
Kelmer E, Shimshoni JA, Merbl Y, Kolski O, Klainbart S.
J. Vet. Emerg. Crit. Care (San Antonio), DOI 10.1111/vec.12872.

Clinical pharmacokinetics of a dexmedetomidine-methadone combination in dogs undergoing routine anaesthesia after buccal or intramuscular administration.
Di Cesare F, Gioeni D, Ravasio G, Pellegrini A, Lucatello L, Bisutti V, Villa R, Cagnardi P.
J. Vet. Pharmacol. Ther., DOI 10.1111/jvp.12771.

Pharmacokinetics of single doses of maropitant citrate in adult horses.
Berryhill EH, Knych H, Edman JM, Magdesian KG.
J. Vet. Pharmacol. Ther., DOI 10.1111/jvp.12768.

Pharmacokinetics of cligosiban in dog plasma after oral administration by liquid chromatography electrospray ionization tandem mass spectrometry.
Xi W, Zou Q, Ouyang P.
Biomed. Chromatogr., DOI 10.1002/bmc.4611.

An LC-MS/MS method for quantification of HR011303, a novel highly selective urate transporter 1 inhibitor in Beagle dogs and the application to a pharmacokinetic study.
Wang J, Yao W, Fan D, Qiu Z, Song J, Pan K, Hang T.
Biomed. Chromatogr., DOI 10.1002/bmc.4604.

Tear fluid pharmacokinetics following oral prednisone administration in dogs with and without conjunctivitis.
Sebbag L, Yan Y, Smith JS, Allbaugh RA, Wulf LW, Mochel JP.
J. Ocul. Pharmacol. Ther., DOI 10.1089/jop.2019.0020.

Enantioselective determination of ketamine in dog plasma by chiral liquid chromatography-tandem mass spectrometry.
Li R, Zhong K, Jiang J, Zhan Y, Chen X.
Biomed. Chromataogr., DOI 10.1002/bmc.4578.

Simultaneous determination of evobrutinib and its metabolite evobrutinib-diol in dog plasma by liquid chromatography combined with electrospray ionization tandem mass spectrometry.
Yang J, Yu H, Tang Q.
Biomed. Chromatogr., DOI 10.1002/bmc.4575.

Development and validation of a simple and sensitive high resolution LC/MS method for determination of PF-04620110 in dog plasma: application to the pharmacokinetic study.
He F, Zheng W, Chen Y, Mo C, Chen Y.
Biomed. Chromataogr., DOI 10.1002/bmc.4562.

Ultrahigh-performance liquid chromatography with tandem mass spectrometry for the determination of 10 alkaloids in beagle plasma after the oral administration of the three Coptidis rhizoma extracts.
Ren Y, Wang Z, Wu C, Dong H, Gan C, Fan L, Wang W, Yang C.
J. Ethnopharmacol., DOI 10.1016/j.jep.2019.111896.

Evaluation of methadone concentrations in bitches and in umbilical cords after epidural or systemic administration for caesarean section: A randomized trial.
Romagnoli N, Barbarossa A, Cunto M, Ballotta G, Zambelli D, Armorini S, Zaghini A, Lambertini C.
Vet. Anaesth. Analg., DOI 10.1016/j.vaa.2018.10.005.

Pharmacokinetics and selected pharmacodynamics of morphine and its active metabolites in horses after intravenous administration of four doses.
Hamamoto-Hardman BD, Steffey EP, Weiner D, McKemie DS, Kass P, Knych HK.
J. Vet. Pharmacol. Ther., DOI 10.1111/jvp.12759.

Pharmacokinetics and safety of repeated oral dosing of acetaminophen in adult horses.
Mercer MA, McKenzie HC, Davis JL, Wilson KE, Hodgson DR, Cecere TE, McIntosh BJ.
Equine Vet. J., DOI 10.1111/evj.13112.

Concentrations of sulphated estrone, estradiol and dehydroepiandrosterone measured by mass spectrometry in pregnant mares.
Legacki EL, Scholtz EL, Ball BA, Esteller-Vico A, Stanley SD, Conley AJ.
Equine Vet. J., DOI 10.1111/evj.13109.

Simultaneous determination of idelalisib and its metabolite GS-563117 in dog plasma by LC-MS/MS: application to a pharmacokinetic study.
Wang C, Jia F, Zhang Y.
Biomed. Chromatogr., DOI 10.1002/bmc.4511.

Diphenhydramine pharmacokinetics after oral and intravenous administration of diphenhydramine and oral administration of dimenhydrinate to healthy dogs, and pharmacodynamic effect on histamine-induced wheal formation: a pilot study.
Ehling S, Bäumer W, Papich MG.
Vet. Dermatol., DOI 10.1111/vde.12727.

Alfaxalone for total intravenous anaesthesia in horses.
Goodwin WA, Pasloske K, Keates HL, Ranasinghe MG, Woldeyohannes S, Perkins N.
Vet. Anaesth. Analg., DOI 10.1016/j.vaa.2018.09.047.

Metabolism of scoparone in experimental animals and humans.
Juvonen RO, Novák F, Emmanouilidou E, Auriola S, Timonen J, Heikkinen AT, Küblbeck J, Finel M, Raunio H.
Planta Med., DOI 10.1055/a-0835-2301.

Pharmacokinetics of harpagoside in horses after intragastric administration of a Devil's claw (Harpagophytum procumbens) extract.
Axmann S, Hummel K, Nöbauer K, Razzazi-Fazeli E, Zitterl-Eglseer K.
J. Vet. Pharmacol. Ther., 2019, 42, 37–44.

Thyroid hormone and thyrotropin concentrations and responses to thyrotropin-stimulating hormone in horses with PPID compared with age-matched normal horses.
Breuhaus BA.
J. Equine Vet. Sci., 2019, 75, 35–40.

Detection of erythropoiesis-stimulating agents (ESAs) in equine urine and blood by SAR-PAGE.
Cavalcanti RTC, Teixeira PAC, Levy RS, Pereira HMG, Aquino Neto FR.
Drug Test. Anal., 2019, 11, 772–781.

Pharmacokinetics of a modified, compounded theophylline product in dogs.
Cavett CL, Li Z, McKiernan BC, Reinhart JM.
J. Vet. Pharmacol. Ther., 2019, 42, 593–601.

Single-dose pharmacokinetics and preliminary safety assessment with use of CBD-rich hemp nutraceutical in healthy dogs and cats.
Deabold KA, Schwark WS, Wolf L, Wakshlag JJ.
Animals (Basel), 2019, 9, 832.

Pharmacokinetics of intrarectal altrenogest in horses.
Ellis KE, Council-Troche RM, Von Dollen KA, Beachler TM, Bailey CS, Davis JL, Lyle SK.
J. Equine Vet. Sci., 2019, 72, 41–46.

Tamoxifen in horses: pharmacokinetics and safety study.
Gajardo G, López-Muñoz R, Plaza A, Uberti B, Sarmiento J, Morán G, Henríquez C.
Ir. Vet. J., 2019, 72, 5.

Pharmacokinetics and metabolism of H3B-6545, a selective estrogen receptor covalent antagonist, in dog plasma by liquid chromatography combined with electrospray ionization tandem mass spectrometry.
Ge Y, Zhang Y, Li X, Yu Y, Liu Q.
J. Pharm. Biomed. Anal., 2019, 172, 189–199.

Simultaneous quantitation of 9 anabolic and natural steroidal hormones in equine urine by UHPLC-MS/MS triple quadrupole.
Genangeli M, Caprioli G, Cortese M, Laus F, Petrelli R, Ricciutelli M, Sagratini G, Sartori S, Vittori S.
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 2019, 1117, 36–40.

A comprehensive approach to detecting multitudinous bioactive peptides in equine plasma and urine using hydrophilic interaction liquid chromatography coupled to high resolution mass spectrometry.
Guan F, You Y, Li X, Robinson MA.
Drug Test. Anal., 2019, 11, 1308–1325.

Age related and seasonal changes of plasma concentrations of insulin-like peptide 3 and testosterone from birth to early-puberty in Thoroughbred male horses.
Hannan MA, Murase H, Sato F, Tsogtgerel M, Kawate N, Nambo Y.
Theriogenology, 2019, 132, 212–217.

Identification of prototype compounds and derived metabolites of naoxintong capsule in Beagle dog urine and feces by UFLC-Q-TOF-MS/MS.
He Y, Su W, Chen T, Zeng X, Yan Z, Guo J, Yang W, Wu H.
J. Pharm. Biomed. Anal., 2019, 176, 112806.

Studies of pharmacokinetics in beagle dogs and drug-drug interaction potential of a novel selective ZAK inhibitor 3h for hypertrophic cardiomyopathy treatment.
Jiang W, Ding L, Dai T, Guo J, Dai R, Chang Y.
J. Pharm. Biomed. Anal., 2019, 172, 206–213.

Simultaneous quantification of tegoprazan and its major metabolite M1 in dog plasma using liquid chromatography-tandem mass spectrometry.
Kim J, Kim S, Noh HJ, Ryu SY, Kim SJ.
J. Pharm. Biomed. Anal., 2019, 171, 99–103.

Detection, pharmacokinetics, and selected pharmacodynamic effects of methamphetamine following a single transmucosal and intravenous administration to exercised Thoroughbred horses.
Knych HK, Arthur RM, Kanarr KL, McKemie DS, Kass PH.
Drug Test. Anal., 2019, 11, 1431–1443.

Phenylbutazone blood and urine concentrations, pharmacokinetics, and effects on biomarkers of inflammation in horses following intravenous and oral administration of clinical doses.
Knych HK, Arthur RM, McKemie DS, Seminoff K, Hamamoto‐Hardman B, Kass PH.
Drug Test. Anal., 2019, 11, 792–803.

Pharmacokinetics of hydroxyzine and cetirizine following oral administration of hydroxyzine to exercised Thoroughbred horses.
Knych HK, Weiner D, Steinmetz S, Flynn K, McKemie DS.
J. Vet. Pharmacol. Ther., 2019, 42, 617–623.

Pharmacokinetic characterizations of ginsenoside ocotillol, RT5 and F11, the promising agents for Alzheimer's disease from American ginseng, in rats and Beagle dogs.
Li Y, Hu H, Li Z, Li R, Xu F, Zhao C, An Y, Liu Y, Wang Z, Zhang B, Geng C.
Pharmacology, 2019, 104, 7–20.

Variability in plasma concentrations of methylprednisolone six days after intrasynovial injection of methylprednisolone acetate in racing horses: A field study.
Machin J, Duer W, Maylin G, Fenger C, Wilson D, Ivey M, Berthold B, Allison S, Tobin T.
Equine Vet. J., 2019, 51, 343–348.

Plasma and urine pharmacokinetics of intravenously administered flunixin in greyhound dogs.
Morris T, Paine SW, Zahra P, Li E, Colgan S, Karamatic S.
J. Vet. Pharmacol. Ther., 2019, 42, 505–510.

Pharmacological regulation in the USA and pharmacokinetics parameters of firocoxib, a highly selective Cox-2, by pain management in horses.
Rangel-Nava A, Ramírez-Uribe JM, Recillas-Morales S, Ibancovichi-Camarillo JA, Venebra-Muñoz A, Sánchez-Aparicio P.
J. Equine Vet. Sci., 2019, 77, 36–42.

Effect of feeding on the pharmacokinetics of vilazodone in dogs.
Sartini I, Gbylik-Sikorska M, Łebkowska-Wieruszewska B, Gajda A, Lisowski A, Kowalski CJ, Posyniak A, Poapolathep A, Giorgi M.
Res. Vet. Scil., 2019, 125, 309–314.

Ionized magnesium and calcium concentration and their ratio in equine plasma samples as determined by a regulatory laboratory compared to a clinical reference laboratory.
Schumacher SA, Yardley J, Bertone AL.
Drug Test. Anal., 2019, 11, 455–460.

Development, validation of LC-MS/MS method and determination of pharmacokinetic parameters of the stroke neuroprotectant neurounina-1 in Beagle dog plasma after intravenous administration.
Severino B, Corvino A, Fiorino F, Frecentese F, Perissutti E, Caliendo G, Santagada V, Magli E, Molinaro P, Pignataro G, Annunziato L, Antunes NJ, Rojas-Moscoso J, de Freitas NL, Mendes GD, De Nucci G.
Front. Pharmacol., 2019, 10, 432.

Metabolism and elimination of the catechol O-methyltransferase inhibitor tolcapone in the horse.
Stanley S, Van den Berg K, Foo HC, Deng D.
Drug Test. Anal., 2019, 11, 578–585.

Tracking main environmental factors masking a minor steroidal doping effect using metabolomic analysis of horse urine by liquid chromatography-high-resolution mass spectrometry.
Stojiljkovic N, Leroux F, Bubanj S, Popot MA, Paris A, Tabet JC, Junot C.
Eur. J. Mass Spectrom. (Chichester), 2019, 25, 339–353.

Pharmacokinetics, metabolism and excretion of celecoxib, a selective cyclooxygenase-2 inhibitor, in horses.
Subhahar MB, Singh J, Albert PH, Kadry AM.
J. Vet. Pharmacol. Ther., 2019, 42, 518–524.

Pilot study to quantify the time to clear dexamethasone from plasma and urine of adult horses following a single nebulisation.
Symonds NE, Dart AJ, Keledjian J, Lau ML, Ennis LC, McIver VC, Tsang AS, Biasutti SA, Jeffcott LB.
Aust. Vet. J., 2019, 97, 144–148.

Effects of vatinoxan on cardiorespiratory function, fecal output and plasma drug concentrations in horses anesthetized with isoflurane and infusion of medetomidine.
Tapio HA, Raekallio MR, Mykkänen AK, Al-Ramahi D, Scheinin M, Hautajärvi HJ, Männikkö S, Vainio O.
Vet. J., 2019, 251, 105345.

An immuno polymerase chain reaction screen for the detection of CJC‐1295 and other growth‐hormone‐releasing hormone analogs in equine plasma.
Timms M, Ganio K, Forbes G, Bailey S, Steel R.
Drug Test. Anal., 2019, 11, 804–812.

A method for confirming CJC‐1295 abuse in equine plasma samples by LC–MS/MS.
Timms M, Ganio K, Steel R.
Drug Test. Anal., 2019, 11, 1248–1257.

Droplet digital PCR detection of the erythropoietin transgene from horse plasma and urine for gene-doping control.
Tozaki T, Ohnuma A, Takasu M, Kikuchi M, Kakoi H, Hirota KI, Kusano K, Nagata SI.
Genes (Basel), 2019, 10, 243.

Identification of metabolomic changes in horse plasma after racing by liquid chromatography-high resolution mass spectrometry as a strategy for doping testing.
Ueda T, Tozaki T, Nozawa S, Kinoshita K, Gawahara H.
J. Equine Sci., 2019, 30, 55–61.

Elucidation of the biosynthetic pathways of boldenone in the equine testis.
Viljanto MJ, Kicman AT, Walker CJ, Parkin MC, Wolff K, Pearce CM, Scarth J.
Steroids, 2019, 146, 79–91.

Pharmacokinetics of furosemide in thoroughbred horses subjected to supramaximal treadmill exercise with and without controlled access to water.
Villarino NF, Lopez CM, Sams RA, Bayly WM.
BMC Vet. Res., 2019, 15, 275.

Pharmacokinetics and pharmacodynamics of intranasal and intravenous naloxone hydrochloride administration in healthy dogs.
Wahler BM, Lerche P, Ricco Pereira CH, Bednarski RM, KuKanich B, Lakritz J, Aarnes TK.
Am. J. Vet. Res., 2019, 80, 696–701.

Clinical pharmacokinetics and pharmacodynamics of intravenous alfaxalone in young Thoroughbred horses premedicated with medetomidine and midazolam.
Wakuno A, Aoki M, Kushiro A, Mae N, Maeda T, Yamazaki Y, Minamijima Y, Nagata SI, Ohta M.
Vet. Rec., 2019, 184, 411.

Nonlinear mixed‐effects pharmacokinetic modeling of the novel COX‐2 selective inhibitor vitacoxib in dogs.
Wang J, Schneider BK, Sun P, Gong X, Qiu J, Li J, Seo Y-J, Mochel JP, Cao X.
J. Vet. Pharmacol. Ther., 2019, 42, 530–540.

A rapid and eco-friendly method for determination of the main components of gamma-oryzanol in equestrian dietary and nutritional supplements by liquid chromatography-Tandem mass spectrometry.
Waraksa E, Kowalski K, Kłodzińska E, Rola R, Ciekot J, Filipiak W, Bieńkowski T, Namieśnik J.
J. Pharm. Biomed. Anal., 2019, 172, 339–348.

Pharmacodynamics and pharmacokinetics of a new type of compound lansoprazole capsule in gastric ulcer rats and Beagle dogs: importance of adjusting oxidative stress and inflammation.
Wei B, Wang Y, Wu H, Liu M, Yao W, Wei M.
Pharmaceutics, 2019, 11, 49.

High-throughput doping control analysis of 28 amphetamine-type stimulants in equine plasma using hydrophilic interaction liquid chromatography-tandem mass spectrometry.
You Y, Guan F, D'Ippolito R, Li X, Soma LR, Robinson MA.
Drug Test. Anal., 2019, 11, 441–454.

Evaluation of plasma concentration after intravenous and intramuscular penicillin administration over 24 hr in healthy adult horses.
Younkin JT, Santschi EM, Kukanich B, Lubbers BV, Warner M.
J. Vet. Pharmacol. Ther., 2019, 11, 38.

Simultaneous quantitation of a novel α₁/β₁-blocker TJ0711 and its two metabolites in dog plasma using LC-MS/MS and its application to a pharmacokinetic study after intravenous infusion.
Zhu W, Liu W, Li H, Xu G, Li Q, Huang J, Li G, Si L.
Pharmaceutics, 2019, 42, 239–242.