1. You are here:
  2. Research
  3. Research Articles
  4. 2020 Articles

2020 Articles

Pharmacokinetic analysis of two different doses of simvastatin following oral administration in dogs.
Kim MS, Baek IH.
J. Vet. Pharmacol. Ther., DOI 10.1111/jvp.12944.

Pharmacokinetics of doxycycline in dogs.
Papich MG.
J. Vet. Pharmacol. Ther., DOI 10.1111/jvp.12941.

Metabolic study of GW1516 in equine urine using liquid chromatography/electrospray ionization Q-Exactive high-resolution mass spectrometer for doping control.
Ishii H, Shibuya M, Leung GNW, Yamashita S, Yamada M, Kushiro A, Kasashima Y, Okada J, Kawasaki K, Kijima-Suda I.
Rapid Commun. Mass Spectrom., DOI 10.1002/rcm.9028.

Stability of ketoprofen methylester in plasma of different species.
Hu SX, Ernst K, Benner CP, Feenstra KL.
Curr. Drug Metab., DOI 10.2174/1389200221666201217141025.

Label-free proteomics for discovering biomarker candidates of RAD140 administration to castrated horses.
Cheung HW, Wong KS, To NS, Bond AJ, Farrington AF, Prabhu A, Curl P, Wan TSM, Ho ENM.
Drug Test. Anal., DOI 10.1002/dta.2988.

Quantitative determination of AZD3264, a selective Ikb-kinase IKK2 inhibitor, in dog plasma by solvent-induced phase transition extraction coupled with HPLC-MS/MS and its application to pharmacokinetic study in dogs.
Li G, Liang S, Qiao K, Wang C.
J. AOAC Int., DOI 10.1093/jaoacint/qsaa134.

In vitro metabolism of slowly cleared GPR139 agonist TAK-041 using rat, dog, monkey and human hepatocyte models (HepatoPac): correlation with in vivo metabolism.
Kamel A, Bowlin S, Hosea N, Arkilo D, Laurenza A.
Drug Metab. Dispos., DOI 10.1124/dmd.120.000246.

Tiludronic acid can be detected in blood and urine samples from Thoroughbred racehorses over three years after last administration.
Riggs CM, Thompson SL, Wong JKY, So YM, Wan TSM, Robinson P, Stewart BD, Ho ENM.
Equine Vet. J., DOI 10.1111/evj.13395.

Metabolism and excretion of the benzodiazepine analog etizolam in the horse.
Johnson E, van Heemst J, Benavides J, Gray B.
Drug Test. Anal., DOI 10.1002/dta.2967.

Pharmacokinetics of doxycycline after oral administration of multiple doses in dogs.
De Lucas JJ, Rodríguez C, San Andrés MD, Sainz A, Villaescusa A, García‐Sancho M, Rodríguez‐Franco F, San Andrés MI.
J. Vet. Pharmacol. Ther., DOI 10.1111/jvp.12926.

The pharmacokinetics and antiparasitic activity of ivermectin in Hutsul and Toric horses.
Vyniarska A, Ziółkowski H, Madej-Śmiechowska H, Jaroszewski JJ.
J. Vet. Pharmacol. Ther., DOI 10.1111/jvp.12924.

Concentration profiles and safety of topically applied betulinic acid and NVX‐207 in eight healthy horses—A randomized, blinded, placebo‐controlled, crossover pilot study.
Weber LA, Puff C, Kalbitz J, Kietzmann M, Feige K, Bosse K, Rohn K, Cavalleri JMV.
J. Vet. Pharm. Toxicol., DOI 10.1111/jvp.12903.

Application of a non-target variable data independent workflow (vDIA) for the screening of prohibited substances in doping control testing.
Leung DKK, Wong ASY, Zhou QL, Wan TSM, Ho ENM.
Drug Test. Anal., DOI 10.1002/dta.2881.

Analysis of illicit glucocorticoid levels in camel hair using competitive ELISA - comparison with LC-MS/MS.
Ashraf SS, El-Gahany W, Alraeesi A, Al-Hajj L, Al-Maidalli A, Shah I.
Drug Test. Anal., 2020, 12, 458–464.

Pharmacokinetics of maropitant citrate after oral administration of multiple doses in adult horses.
Berryhill EH, Knych H, Chigerwe M, Edman J, Magdesian KG.
J. Vet. Pharmacol. Ther., 2020, 43, 282–287.

Doping control analysis of total arsenic in equine plasma.
Chan GHM, Tang W, Curl P, Lin Y, Wan TSM, Ho ENM.
Drug Test. Anal., 2020, 12, 1462–1469.

Determination of grapiprant plasma and urine concentrations in horses.
Cox S, Sommardahl C, Fortner C, Davis R, Bergman J, Doherty T.
Vet. Anaesth. Analg., 2020, 47, 705–709.

Investigation of the metabolism of the selective androgen receptor modulator LGD-4033 in equine urine, plasma and hair following oral administration.
Cutler C, Viljanto M, Hincks P, Habershon-Butcher J, Muir T, Biddle S.
Drug Test. Anal., 2020, 12, 247–260.

Screening and confirmatory analysis of recombinant Human EPO for racing camels' doping control.
Delcourt V, Garcia P, Chabot B, Loup B, Remy P, Popot MA, Bailly-Chouriberry L.
Drug Test. Anal., 2020, 12, 763–770.

Pharmacokinetics and analgesic efficacy of intranasal administration of tramadol in dogs after ovariohysterectomy.
Di Salvo A, Conti MB, Nannarone S, Bufalari A, Giorgi M, Moretti G, Marenzoni ML, Della Rocca G.
Vet. Anaesth. Analg., 2020, 47, 557–566.

Field-amplified sample injection in capillary zone electrophoresis for the pharmacokinetic research of trace risperidone and its major metabolite 9-hydroxyrisperidone in beagle dogs.
Fan X, Li J, Wu S, Jiang J, Wang J, Wang S, Lou Y, Fan G.
J. Sep. Sci., 2020, 43, 3555–3564.

An innovative derivatization-free IC-MS/MS method for the detection of bisphosphonates in horse plasma.
Garcia P, Pinètre J, Morel S, Jaubert M, Deruy X, Perot I, Delcourt V, Loup B, Popot MA, Bailly-Chouriberry L.
Drug Test. Anal., 2020, 12, 1452–1461.

Quantification and validation of nine non-steroidal anti-inflammatory drugs in equine urine by gas chromatography mass spectrometry for doping control.
Göktaş EF, Kabil E, Arıöz F.
Drug Test. Anal., 2020, 12, 1065–1077.

Investigations into the analysis of intact drug conjugates in animal sport doping control - development and assessment of a rapid and economical approach for screening greyhound urine.
Gray B, Tuckley L, Cutler C, Biddle S, Hudson S, Gower S, Vanhaecke L.
Drug Test. Anal., 2020, 12, 731–742.

Metabolism, pharmacokinetics and selected pharmacodynamic effects of codeine following a single oral administration to horses.
Gretler SR, Finno CJ, McKemie DS, Kass PH, Knych HK.
Vet. Anaesth. Analg., 2020, 47, 694–704.

Identification of ex vivo catabolites of peptides with doping potential in equine plasma by HILIC‐HRMS
Guan F, Fay S, Li X, You Y, Robinson MA.
Drug Test. Anal., 2020, 12, 771–784.

Pharmacokinetics and clinical effects of xylazine and dexmedetomidine in horses recovering from isoflurane anesthesia.
Guedes A, Knych H, Tucker L, Almeida DC, Baldo CF, Wendt‐Hornickle E, Allweiler S.
J. Vet. Pharmacol. Ther., 2020, 43, 369–376.

Re‐evaluation of the pharmacokinetics of xylazine administered to Thoroughbred horses.
Habershon‐Butcher J, Cutler C, Viljanto M, Hincks PR, Biddle S, Paine SW.
J. Vet. Pharmacol. Ther., 2020, 43, 6–12.

Meperidine pharmacokinetics and effects on physiologic parameters and thermal threshold following intravenous administration of three doses to horses.
Hamamoto-Hardman BD, Steffey EP, McKemie DS, Kass PH, Knych HK.
BMC Vet. Res., 2020, 16, 368.

Serum cannabidiol, tetrahydrocannabinol (THC), and their native acid derivatives after transdermal application of a low-THC Cannabis sativa extract in beagles.
Hannon MB, Deabold KA, Talsma BN, Lyubimov A, Iqbal A, Zakharov A, Gamble LJ, Wakshlag JJ.
J. Vet. Pharmacol. Ther., 2020, 43, 508–511.

Detection of intra‐articular gene therapy in horses using quantitative real time PCR in synovial fluid and plasma.
Haughan J, Jiang Z, Stefanovski D, Moss KL, Ortved KF, Robinson MA.
Drug Test.Anal., 2020, 12, 743–751.

Pharmacokinetics and biotransformation investigation in beagle dog of active compounds from naoxintong capsule.
He Y, Su W, He X, Chen T, Zeng X, Yan Z, Zhang W, Yang W, Guo J, Wu H.
Biomed. Pharmacother. J., 2020, 133, 110940.

Concentrations of medetomidine enantiomers and vatinoxan, an α2-adrenoceptor antagonist, in plasma and central nervous tissue after intravenous coadministration in dogs.
Honkavaara JM, Raekallio MR, Syrja PM, Pypendop BH, Knych HK, Kallio-Kujala IJ, Vainio OM.
Vet. Anaesth. Analg., 2020, 47, 47–52.

Pharmacokinetics of xylazine after 2‐, 4‐, and 6‐hr durations of continuous rate infusions in horses.
Hopster K, Soma LR, Li X, Hopster‐Iversen C, Boston RC, Driessen B.
J. Vet. Pharmacol. Ther., 2020, 43, 557–564.

Pharmacokinetic and bioavailability study of kurarinone in dog plasma by UHPLC-MS/MS.
Huang Y, Lin H, Chen Y, Huang X.
Biomed. Chromatogr., 2020, 34, e4945.

Quantitative analysis of paracetamol, metacetamol, and orthocetamol in equine urine from racehorses in Japan using liquid chromatography-electrospray ionisation-tandem mass spectrometry.
Ishii H, Obara T, Kusano K, Kijima-Suda I.
Drug Test. Anal., 2020, 12, 1196–1202.

Simultaneous measurement of acalabrutinib, ibrutinib, and their metabolites in beagle dog plasma by UPLC-MS/MS and its application to a pharmacokinetic study.
Jiang Z, Shi L, Zhang Y, Lin G , Wang Y.
J. Pharm. Biomed. Anal., 2020, 191, 113613.

Is 9β-dehydrohalogenation of betamethasone and dexamethasone hindering the detection of banned co-eluting meprednisone? A reverse-phase chiral liquid chromatography high-resolution mass spectrometry approach.
Karatt TK, Sathiq MA, Laya S.
Steroids, 2020, 155, 108572.

Pharmacokinetics of morphine in combination with dexmedetomidine and maropitant following intramuscular injection in dogs anaesthetized with halothane.
Karna SR, Singh P, Chambers P, Kongara K.
J. Vet. Pharmacol. Ther., 2020, 43, 153–161.

Separation and determination of the enantiomeric levamisole and dexamisolein equine plasma samples using chiral polysaccharide column/LC-MS/MS.
Karakka Kal AK, Karatt TK, Philip M, Meissir S, Nalakath J.
Curr. Anal. Chem., 2020, 16, 761–767.

Development and validation of a chiral LC‐MS method for the enantiomeric resolution of (+) and (−)‐medetomidine in equine plasma by using polysaccharide‐based chiral stationary phases.
Karakka Kal AK, Nalakath J, Karatt TK, Perwad Z, Mathew B, Subhahar M.
Chirality, 2020, 32, 314–323.

Using inductively coupled plasma mass spectrometry to assess essential and performance-enhancing metals in the urine of racehorses.
Karakka Kal AK, Perwad Z, Karatt TK, Nalakath J, Subhahar M.
J. Anal. Toxicol., 2020, 44, 490–498.

Pharmacokinetic analysis of mosapride following intravenous and oral administration in beagle dogs.
Kim MS, Baek IH.
J. Vet. Pharmacol. Ther., 2020, 43, 454–460.

Serum concentrations, pharmacokinetic/pharmacodynamic modeling, and effects of dexamethasone on inflammatory mediators following intravenous and oral administration to exercised horses.
Knych HK, Weiner D, Arthur RM, Baden R, McKemie DS, Kass PH.
Drug Test. Anal., 2020, 12, 1087–1101.

Detection of bioactive peptides including gonadotrophin-releasing factors (GnRHs) in horse urine using ultra-high performance liquid chromatography-high resolution mass spectrometry (UHPLC/HRMS).
Kwok KY, Choi TLS, Kwok WH, Lau MY, Leung EMK, Leung GNW, Wong JKY, Wan TSM, Adrian FF, Prabhu A, Ho ENM.
Drug Test. Anal., 2020, 12, 1274–1286.

Administration study of recombinant human relaxin-2 in horse for doping control purpose.
Kwok WH, Choi TLS, Leung GNW, Wong ASY, Yue SK, Wan TSM, Ho ENM.
Drug Test. Anal., 2020, 12, 361–370.

Simultaneous determination of donepezil, 6-O-desmethyl donepezil and spinosin in beagle dog plasma using liquid chromatography‒tandem mass spectrometry and its application to a drug-drug interaction study.
Lee CB, Min JS, Chae SU, Kim HM, Jang JH, Jung IH, Zheng YF, Ryu JH, Bae SK.
J. Pharm. Biomed. Anal., 2020, 178, 112919.

Pharmacokinetics and bioavailability of ipatasertib in dog plasma by LC/MS/MS.
Liu Y, Ma C, Jiao W, Yang Y, Zhang H, Du L, Ma M, Sun P, Li X, Chen J.
Biomed. Chromatogr., 2020, 34, e4923.

Pharmacokinetics and pharmacodynamics of hydromorphone hydrochloride in healthy horses.
Martins FC, Keating SC, Clark-Price SC, Schaeffer DJ, Lascola KM, DiMaio Knych H.
Vet. Anaesth. Analg., 2020, 47, 509–517.

Comparative pharmacokinetics of imepitoin after oral and rectal administration in healthy dogs.
Martlé V, Devreese M, Rauch S, Van Ham L, Croubels S, Vanhoorne V, Vervaet C, Bhatti S.
Vet. J., 2020, 259–260, 105459.

Pharmacokinetics and safety of mitragynine in beagle dogs.
Maxwell EA, King TI, Kamble SH, Raju KSR, Berthold EC, León F, Avery BA, McMahon LR, McCurdy CR, Sharma A.
Planta Med., 2020, 86, 1278–1285.

Comparison of immunofluorescence and chemiluminescence assays for measuring ACTH in equine plasma.
McGilvray TA, Knowles EJ, Harris PA, Menzies-Gow NJ.
Equine Vet. J., 2020, 52, 709–714.

Pharmacokinetics and safety of repeated oral dosing of acetaminophen in adult horses.
Mercer MA, McKenzie HC, Davis JL, Wilson KE, Hodgson DR, Cecere TE, McIntosh BJ.
Equine Vet. J., 2020, 52, 120–125.

Morphine plasmatic concentration in a pregnant mare and its foal after long term epidural administration.
Mirra A, Birras J, Diez Bernal S, Spadavecchia C.
BMC Vet Res., 2020, 16, 19.

Presence of antimicrobials in postrace samples in Japanese Thoroughbred racing.
Mizobe F, Mori M, Nagata SI, Yamashita S, Okada J, Kusano K.
J. Equine Vet. Sci., 2020, 91, 103115.

Pharmacokinetics of carprofen and firocoxib for medication control in racing greyhounds.
Morris TH, Paine SW, Zahra PW, Li EC, Colgan SA, Karamatic SL.
Aust. Vet. J., 2020, 98, 578–585.

Pharmacokinetics and efficacy of trazodone following rectal administration of a single dose to healthy dogs.
O'Donnell EM, Press SA, Karriker MJ, Istvan SA.
Am. J. Vet. Res., 2020, 81, 739–746.

Metabolism and pharmacokinetics characterization of metarrestin in multiple species.
Padilha EC, Shah P, Wang AQ, Singleton MD, Hughes EA, Li D, Rice KA, Konrath KM, Patnaik S, Marugan J, Rudloff U, Xu X.
Cancer Chemother. Pharmacol., 2020, 85, 805–816.

The intravenous pharmacokinetics of butorphanol and detomidine dosed in combination compared with individual dose administrations to exercised horses.
Paine SW, Bright J, Scarth JP, Hincks PR, Pearce CM, Hannan C, Machnik M, Hillyer L.
J. Vet. Pharmacol. Ther., 2020, 43, 162–170.

Population pharmacokinetics and pharmacodynamics modeling of torasemide and furosemide after oral repeated administration in healthy dogs.
Pelligand L, Guillot E, Geneteau A, Guyonnet J, Magnier R, Elliott J, Peyrou M, Jacobs M.
Front. Vet. Sci., 2020, 7, 151.

Comparative pharmacokinetics and pharmacodynamics of the advanced Retinol-Binding Protein 4 antagonist in dog and cynomolgus monkey.
Racz B, Varadi A, Pearson PG, Petrukhin K.
PLoS One, 2020, 15, e0228291.

Pharmacokinetic study of oral amitriptyline in horses.
Recchi L, Alvariza S, Benech A, Ruiz N, Estradé MJ, Suarez G, Crosignani N.
J. Vet. Pharmacol. Ther., 2020, 43, 381–384.

Determination of oroxylin A, oroxylin A 7-O-glucuronide, and oroxylin A sodium sulfonate in beagle dogs via ultra-high-performance liquid chromatography/tandem mass spectrometry: Application in a pharmacokinetic study.
Ren G, Chen H, Zhang M, Yang N, Yang H, Xu C, Li J, Ning C, Song Z, Zhou S, Zhang S, Wang X, Lu Y, Li N, Zhang Y, Chen X, Zhao D.
J. Sep. Sci., 2020, 43, 2290–2300.

Pharmacokinetics of low-dose methotrexate in horses.
Rostang A, Desjardins I, Espana B, Panzuti P, Berny P, Prouillac C, Pin D.
J. Vet. Pharmacol. Ther., 2020, 43, 461–469.

Separation and identification of the enantiomeric doping agent racemorphan in equine urine by using normal phase chiral-high resolution mass spectrometry.
Sayed R, Karakka Kal AK, Karatt TK, Perwad Z, Nalakath J, Subhahar M.
Anal. Chem. Lett., 2020, 9, 747–756.

Development of a novel and quick UPLC-MS/MS method for the pharmacokinetic analysis of duvelisib in beagle dogs.
Shao Y, Xie S, Zhu H, Du X, Xu RA.
J. Pharm. Biomed. Anal., 2020, 187, 113355.

Detection and pharmacokinetics of etoricoxib in Thoroughbred horses.
Subhahar MB, Singh J, Albert PH, Kadry AM.
J. Equine Vet. Sci., 2020, 88, 102942.

Extraction of α‐neurotoxins from equine plasma by receptor based affinity purification.
Timms M, Ganio K, Steel R.
Drug Test. Anal., 2020, 12, 918–928.

Tozaki T, Ohnuma A, Kikuchi M, Ishige T, Kakoi H, Hirota KI, Hamilton NA, Kusano K, Nagata SI.
J. Equine Sci., 2020, 31, 75–83.

Microfluidic quantitative PCR detection of 12 transgenes from horse plasma for gene doping control.
Tozaki T, Ohnuma A, Kikuchi M, Ishige T, Kakoi H, Hirota KI, Kusano K, Nagata SI.
Genes (Basel), 2020, 11, E457.

Development of a multi-residue high-throughput UHPLC-MS/MS method for routine monitoring of SARM compounds in equine and bovine blood.
Ventura E, Gadaj A, Buckley T, Mooney MH.
Drug Test. Anal., 2020, 12, 1373–1379.

Bioformation of boldenone and related precursors/metabolites in equine faeces and urine, with relevance to doping control.
Viljanto M, Kicman AT, Walker CJ, Wolff K, Muir T, Hincks P, Biddle S, Scarth J.
Drug Test. Anal., 2020, 12, 215–229.

Pharmacokinetics of cannabidiol, cannabidiolic acid, Δ9-tetrahydrocannabinol, tetrahydrocannabinolic acid and related metabolites in canine serum after dosing with three oral forms of hemp extract.
Wakshlag JJ, Schwark WS, Deabold KA, Talsma BN, Cital S, Lyubimov A, Iqbal A, Zakharov A.
Front. Vet. Sci., 2020, 7, 505.

In vivo metabolism of the designer anabolic steroid hemapolin in the Thoroughbred horse.
Waller CC, Weththasinghe SA, McClure L, Cawley AT, Suann C, Suann E, Sutherland E, Cooper E, Heather A, McLeod MD.
Drug Test. Anal., 2020, 12, 752–762.

Pharmacokinetics of three formulations of vitacoxib in horses.
Wang J, Qiu J, Xiao H, Gong X, Sun P, Li J, Zhang S, Cao X.
J. Vet. Pharmacol. Ther., 2020, 43, 364–368.

Determination of bromhexine and its metabolites in equine serum samples by liquid chromatography-tandem mass spectrometry: applicability to the elimination study after single oral dose.
Waraksa E, Owczarek K, Kubica P, Kłodzińska E, Ozimek M, Wrzesień R, Bobrowska-Korczak B, Namieśnik J.
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 2020, 1151, 122197.

Doping control analysis of antipsychotics and other prohibited substances in equine plasma by liquid chromatography/tandem mass spectrometry.
Wong ASY, Choi TLS, Kwok KY, Wong JKY, Wan TSM, Ho ENM.
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 2020, 1147, 122132.

A high-throughput and broad spectrum screening method for analysing over 120 drugs in horse urine by liquid chromatography-high resolution mass spectrometry.
Wong JKY, Chan GHM, Choi TLS, Kwok KY, Lau MY, Leung GNW, Wan TSM, Ho ENM.
Drug Test. Anal., 2020, 12, 900–917.

Pharmacokinetics and tolerability of the novel non-immunosuppressive fingolimod derivative, OSU-2S, in dogs and comparisons with data in mice and rats.
Xie Z, Chen M, Goswami S, Mani R, Wang D, Kulp SK, Coss CC, Schaaf LJ, Cui F, Byrd JC, Jennings RN, Schober KK, Freed C, Lewis S, Malbrue R, Muthusamy N, Bennett C, Kisseberth WC, Phelps MA.
AAPS J., 2020, 22, 92.

A validated LC-MS/MS method for the quantification of capivasertib in dog plasma: application to its pharmacokinetics study.
Zhang Z, Nong L, Chen ML, Liu MH, Cheng WW.
Biomed. Chromatogr., 2020, 34, e4920.

Magnetic solid phase extraction followed with LC-MS/MS for determination of glimepiride in beagle dog plasma and its application to bioequivalence study.
Zhu J, Li Y, Xiang Y, Zhou L, Li Y.
J. Pharm. Biomed. Anal., 2020, 184, 113180.