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2020 Articles

An innovative derivatization-free IC-MS/MS method for the detection of bisphosphonates in horse plasma.
Garcia P, Pinètre J, Morel S, Jaubert M, Deruy X, Perot I, Delcourt V, Loup B, Popot M-A, Bailly-Chouriberry L.
Drug Test. Anal., DOI 10.1002/dta.2892.

Application of a non-target variable data independent workflow (vDIA) for the screening of prohibited substances in doping control testing.
Leung DKK, Wong ASY, Zhou QL, Wan TSM, Ho ENM.
Drug Test. Anal., DOI 10.1002/dta.2881.

Field-amplified sample injection in capillary zone electrophoresis for the pharmacokinetic research of trace risperidone and its major metabolite 9-hydroxyrisperidone in beagle dogs.
Fan X, Li J, Wu S, Jiang J, Wang J, Wang S, Lou Y, Fan G.
J. Sep. Sci., DOI 10.1002/jssc.202000252.

Detection of bioactive peptides including gonadotrophin-releasing factors (GnRHs) in horse urine using ultra-high performance liquid chromatography-high resolution mass spectrometry (UHPLC/HRMS).
Kwok KY, Choi TLS, Kwok WH, Lau MY, Leung EMK, Leung GNW, Wong JKY, Wan TSM, Adrian FF, Prabhu A, Ho ENM.
Drug Test. Anal., DOI 10.1002/dta.2880.

A validated LC-MS/MS method for the quantification of capivasertib in dog plasma: application to its pharmacokinetics study.
Zhang Z, Nong L, Chen ML, Liu MH, Cheng WW.
Biomed. Chromatogr., DOI 10.1002/bmc.4920.

Pharmacokinetics and bioavailability of ipatasertib in dog plasma by LC/MS/MS.
Liu Y, Ma C, Jiao W, Yang Y, Zhang H, Du L, Ma M, Sun P, Li X, Chen J.
Biomed. Chromatogr., DOI 10.1002/bmc.4923.

Pharmacokinetics and analgesic efficacy of intranasal administration of tramadol in dogs after ovariohysterectomy.
Di Salvo A, Conti MB, Nannarone S, Bufalari A, Giorgi M, Moretti G, Marenzoni ML, Della Rocca G.
Vet. Anaesth. Analg., DOI 10.1016/j.vaa.2019.12.011.

Determination of bromhexine and its metabolites in equine serum samples by liquid chromatography-tandem mass spectrometry: applicability to the elimination study after single oral dose.
Waraksa E, Owczarek K, Kubica P, Kłodzińska E, Ozimek M, Wrzesień R, Bobrowska-Korczak B, Namieśnik J.
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., DOI 10.1016/j.jchromb.2020.122197.

Development of a multi-residue high-throughput UHPLC-MS/MS method for routine monitoring of SARM compounds in equine and bovine blood.
Ventura E, Gadaj A, Buckley T, Mooney MH.
Drug Test. Anal., DOI 10.1002/dta.2875.

Quantification and validation of nine non-steroidal anti-inflammatory drugs in equine urine by gas chromatography mass spectrometry for doping control.
Göktaş EF, Kabil E, Arıöz F.
Drug Test. Anal., DOI 10.1002/dta.2864.

Pharmacokinetics of xylazine after 2‐, 4‐, and 6‐hr durations of continuous rate infusions in horses.
Hopster K, Soma LR, Li X, Hopster‐Iversen C, Boston RC, Driessen B.
J. Vet. Pharmacol. Ther., DOI 10.1111/jvp.12873.

Quantitative analysis of paracetamol, metacetamol, and orthocetamol in equine urine from racehorses in Japan using liquid chromatography-electrospray ionisation-tandem mass spectrometry.
Ishii H, Obara T, Kusano K, Kijima-Suda I.
Drug Test. Anal., DOI 10.1002/dta.2860.

Determination of grapiprant plasma and urine concentrations in horses.
Cox S, Sommardahl C, Fortner C, Davis R, Bergman J, Doherty T.
Vet. Anaesth. Analg., DOI 10.1016/j.vaa.2020.04.006.

Pharmacokinetics and pharmacodynamics of hydromorphone hydrochloride in healthy horses.
Martins FC, Keating SC, Clark-Price SC, Schaeffer DJ, Lascola KM, DiMaio Knych H.
Vet. Anaesth. Analg., DOI 10.1016/j.vaa.2020.03.005.

Pharmacokinetic analysis of mosapride following intravenous and oral administration in beagle dogs.
Kim MS, Baek IH.
J. Vet. Pharmacol. Ther., DOI 10.1111/jvp.12867.

A high-throughput and broad spectrum screening method for analysing over 120 drugs in horse urine by liquid chromatography-high resolution mass spectrometry.
Wong JKY, Chan GHM, Choi TLS, Kwok KY, Lau MY, Leung GNW, Wan TSM, Ho ENM.
Drug Test. Anal., DOI 10.1002/dta.2799.

Pharmacokinetics of low-dose methotrexate in horses.
Rostang A, Desjardins I, Espana B, Panzuti P, Berny P, Prouillac C, Pin D.
J. Vet. Pharmacol. Ther., DOI 10.1111/jvp.12857.

Metabolism and pharmacokinetics characterization of metarrestin in multiple species.
Padilha EC, Shah P, Wang AQ, Singleton MD, Hughes EA, Li D, Rice KA, Konrath KM, Patnaik S, Marugan J, Rudloff U, Xu X.
Cancer Chemother. Pharmacol., DOI 10.1007/s00280-020-04042-y.

Determination of oroxylin A, oroxylin A 7-O-glucuronide, and oroxylin A sodium sulfonate in beagle dogs via ultra-high-performance liquid chromatography/tandem mass spectrometry: Application in a pharmacokinetic study.
Ren G, Chen H, Zhang M, Yang N, Yang H, Xu C, Li J, Ning C, Song Z, Zhou S, Zhang S, Wang X, Lu Y, Li N, Zhang Y, Chen X, Zhao D.
J. Sep. Sci., DOI 10.1002/jssc.201901259.

Pharmacokinetics and clinical effects of xylazine and dexmedetomidine in horses recovering from isoflurane anesthesia.
Guedes A, Knych H, Tucker L, Almeida DC, Baldo CF, Wendt‐Hornickle E, Allweiler S.
J. Vet. Pharmacol. Ther., DOI 10.1111/jvp.12855.

Pharmacokinetics of three formulations of vitacoxib in horses.
Wang J, Qiu J, Xiao H, Gong X, Sun P, Li J, Zhang S, Cao X.
J. Vet. Pharmacol. Ther., DOI 10.1111/jvp.12852.

Pharmacokinetics and anti-inflammatory effects of flunixin meglumine as a sole agent and in combination with phenylbutazone in exercised Thoroughbred horses.
Knych HK, Arthur RM, McKemie DS, Baden RW, Seminoff K, Kass PH.
Equine Vet. J., DOI 10.1111/evj.13260.

Pharmacokinetics of maropitant citrate after oral administration of multiple doses in adult horses.
Berryhill EH, Knych H, Chigerwe M, Edman J, Magdesian KG.
J. Vet. Pharmacol. Ther., DOI 10.1111/jvp.12844.

The intravenous pharmacokinetics of butorphanol and detomidine dosed in combination compared with individual dose administrations to exercised horses.
Paine SW, Bright J, Scarth JP, Hincks PR, Pearce CM, Hannan C, Machnik M, Hillyer L.
J. Vet. Pharmacol. Ther., DOI 10.1111/jvp.12838.

Using inductively coupled plasma mass spectrometry to assess essential and performance-enhancing metals in the urine of racehorses.
Abdul Khader KK, Perwad Z, Karatt TK, Nalakath J, Subhahar M.
J. Anal. Toxicol., DOI 10.1093/jat/bkaa004.

Development and validation of a chiral LC‐MS method for the enantiomeric resolution of (+) and (−)‐medetomidine in equine plasma by using polysaccharide‐based chiral stationary phases.
Abdul Khader KK, Nalakath J, Karatt TK, Perwad Z, Mathew B, Subhahar M.
Chirality, DOI 10.1002/chir.23166.

Comparison of immunofluorescence and chemiluminescence assays for measuring ACTH in equine plasma.
McGilvray TA, Knowles EJ, Harris PA, Menzies-Gow NJ.
Equine Vet. J., DOI 10.1111/evj.13227.

Analysis of illicit glucocorticoid levels in camel hair using competitive ELISA - comparison with LC-MS/MS.
Ashraf SS, El-Gahany W, Alraeesi A, Al-Hajj L, Al-Maidalli A, Shah I.
Drug Test. Anal., 2020, 12, 458–464.

Investigation of the metabolism of the selective androgen receptor modulator LGD-4033 in equine urine, plasma and hair following oral administration.
Cutler C, Viljanto M, Hincks P, Habershon-Butcher J, Muir T, Biddle S.
Drug Test. Anal., 2020, 12, 247–260.

Screening and confirmatory analysis of recombinant Human EPO for racing camels' doping control.
Delcourt V, Garcia P, Chabot B, Loup B, Remy P, Popot MA, Bailly-Chouriberry L.
Drug Test. Anal., 2020, 12, 763–770.

Investigations into the analysis of intact drug conjugates in animal sport doping control - development and assessment of a rapid and economical approach for screening greyhound urine.
Gray B, Tuckley L, Cutler C, Biddle S, Hudson S, Gower S, Vanhaecke L.
Drug Test. Anal., 2020, 12, 731–742.

Identification of ex vivo catabolites of peptides with doping potential in equine plasma by HILIC‐HRMS
Guan F, Fay S, Li X, You Y, Robinson MA.
Drug Test. Anal., 2020, 12, 771–784.

Re‐evaluation of the pharmacokinetics of xylazine administered to Thoroughbred horses.
Habershon‐Butcher J, Cutler C, Viljanto M, Hincks PR, Biddle S, Paine SW.
J. Vet. Pharmacol. Ther., 2020, 43, 6–12.

Detection of intra‐articular gene therapy in horses using quantitative real time PCR in synovial fluid and plasma.
Haughan J, Jiang Z, Stefanovski D, Moss KL, Ortved KF, Robinson MA.
Drug Test.Anal., 2020, 12, 743–751.

Concentrations of medetomidine enantiomers and vatinoxan, an α2-adrenoceptor antagonist, in plasma and central nervous tissue after intravenous coadministration in dogs.
Honkavaara JM, Raekallio MR, Syrja PM, Pypendop BH, Knych HK, Kallio-Kujala IJ, Vainio OM.
Vet. Anaesth. Analg., 2020, 47, 47–52.

Is 9β-dehydrohalogenation of betamethasone and dexamethasone hindering the detection of banned co-eluting meprednisone? A reverse-phase chiral liquid chromatography high-resolution mass spectrometry approach.
Karatt TK, Sathiq MA, Laya S.
Steroids, 2020, 155, 108572.

Pharmacokinetics of morphine in combination with dexmedetomidine and maropitant following intramuscular injection in dogs anaesthetized with halothane.
Karna SR, Singh P, Chambers P, Kongara K.
J. Vet. Pharmacol. Ther., 2020, 43, 153–161.

Administration study of recombinant human relaxin-2 in horse for doping control purpose.
Kwok WH, Choi TLS, Leung GNW, Wong ASY, Yue SK, Wan TSM, Ho ENM.
Drug Test. Anal., 2020, 12, 361–370.

Simultaneous determination of donepezil, 6-O-desmethyl donepezil and spinosin in beagle dog plasma using liquid chromatography‒tandem mass spectrometry and its application to a drug-drug interaction study.
Lee CB, Min JS, Chae SU, Kim HM, Jang JH, Jung IH, Zheng YF, Ryu JH, Bae SK.
J. Pharm. Biomed. Anal., 2020, 178, 112919.

Comparative pharmacokinetics of imepitoin after oral and rectal administration in healthy dogs.
Martlé V, Devreese M, Rauch S, Van Ham L, Croubels S, Vanhoorne V, Vervaet C, Bhatti S.
Vet. J., 2020, 259–260, 105459.

Pharmacokinetics and safety of repeated oral dosing of acetaminophen in adult horses.
Mercer MA, McKenzie HC, Davis JL, Wilson KE, Hodgson DR, Cecere TE, McIntosh BJ.
Equine Vet. J., 2020, 52, 120–125.

Morphine plasmatic concentration in a pregnant mare and its foal after long term epidural administration.
Mirra A, Birras J, Diez Bernal S, Spadavecchia C.
BMC Vet Res., 2020, 16, 19.

Population pharmacokinetics and pharmacodynamics modeling of torasemide and furosemide after oral repeated administration in healthy dogs.
Pelligand L, Guillot E, Geneteau A, Guyonnet J, Magnier R, Elliott J, Peyrou M, Jacobs M.
Front. Vet. Sci., 2020, 7, 151.

Comparative pharmacokinetics and pharmacodynamics of the advanced Retinol-Binding Protein 4 antagonist in dog and cynomolgus monkey.
Racz B, Varadi A, Pearson PG, Petrukhin K.
PLoS One, 2020, 15, e0228291.

Separation and identification of the enantiomeric doping agent racemorphan in equine urine by using normal phase chiral-high resolution mass spectrometry.
Sayed R, Abdul Khader KK, Karatt TK, Perwad Z, Nalakath J, Subhahar M.
Anal. Chem. Lett., 2020, 9, 747–756.

Development of a novel and quick UPLC-MS/MS method for the pharmacokinetic analysis of duvelisib in beagle dogs.
Shao Y, Xie S, Zhu H, Du X, Xu R-A.
J. Pharm. Biomed. Anal., 2020, 187, 113355.

Detection and pharmacokinetics of etoricoxib in Thoroughbred horses.
Subhahar MB, Singh J, Albert PH, Kadry AM.
J. Equine Vet. Sci., 2020, 88, 102942.

Microfluidic quantitative PCR detection of 12 transgenes from horse plasma for gene doping control.
Tozaki T, Ohnuma A, Kikuchi M, Ishige T, Kakoi H, Hirota KI, Kusano K, Nagata SI.
Genes (Basel), 2020, 11, E457.

Bioformation of boldenone and related precursors/metabolites in equine faeces and urine, with relevance to doping control.
Viljanto M, Kicman AT, Walker CJ, Wolff K, Muir T, Hincks P, Biddle S, Scarth J.
Drug Test. Anal., 2020, 12, 215–229.

In vivo metabolism of the designer anabolic steroid hemapolin in the Thoroughbred horse.
Waller CC, Weththasinghe SA, McClure L, Cawley AT, Suann C, Suann E, Sutherland E, Cooper E, Heather A, McLeod MD.
Drug Test. Anal., 2020, 12, 752–762.

Doping control analysis of antipsychotics and other prohibited substances in equine plasma by liquid chromatography/tandem mass spectrometry.
Wong ASY, Choi TLS, Kwok KY, Wong JKY, Wan TSM, Ho ENM.
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 2020, 1147, 122132.

Magnetic solid phase extraction followed with LC-MS/MS for determination of glimepiride in beagle dog plasma and its application to bioequivalence study.
Zhu J, Li Y, Xiang Y, Zhou L, Li Y.
J. Pharm. Biomed. Anal., 2020, 184, 113180.