2021 Articles
Plasma levels of a methadone constant rate infusion and their corresponding effects on thermal and mechanical nociceptive thresholds in dogs.
Amon T, Kästner SBR, Kietzmann M, Tünsmeyer J.
BMC Vet. Res., 2021, 17, 35.
Abstract
The effect of serial administration of bicarbonate on plasma total CO2 concentrations in horses.
Bailey SR, Forbes G, Selvadurai N, McLarney K, Jones S, Steel CM.
Drug Test. Anal., 2021, 13, 397–403.
Abstract
A quick approach for medetomidine enantiomers determination in dog plasma by chiral LC-MS/MS and application to a pharmacokinetic study.
Bardhi A, Zaghini A, Levionnois O, Barbarossa A.
Drug Test. Anal., 2021, 13, 1249–1255.
Abstract
Investigation of equine in vivo and in vitro derived metabolites of the selective androgen receptor modulator (SARM) ACP-105 for improved doping control.
Broberg MN, Knych H, Bondesson U, Pettersson C, Stanley S, Thevis M, Hedeland M.
Metabolites, 2021, 11, 85.
Abstract
Quantification of 17 endogenous and exogenous steroidal hormones in equine and bovine blood for doping control with UHPLC-MS/MS.
Caprioli G, Genangeli M, Mustafa AM, Petrelli R, Ricciutelli M, Sagratini G, Sartori S, Laus F, Vittori S, Cortese M.
Pharmaceuticals (Basel), 2021, 14, 393.
Abstract
A duplex qPCR assay for human erythropoietin (EPO) transgene to control gene doping in horses.
Cheung HW, Wong KS, Lin VYC, Wan TSM, Ho ENM.
Drug Test. Anal., 2021, 13, 113–121.
Abstract
Label-free proteomics for discovering biomarker candidates of RAD140 administration to castrated horses.
Cheung HW, Wong KS, To NS, Bond AJ, Farrington AF, Prabhu A, Curl P, Wan TSM, Ho ENM.
Drug Test. Anal., 2021, 13, 1034–1047.
Abstract
Bioanalysis of niclosamide in plasma using liquid chromatography-tandem mass and application to pharmacokinetics in rats and dogs.
Choi HI, Kim T, Lee SW, Woo Kim J, Ju Noh Y, Kim GY, Jin Park H, Chae YJ, Lee KR, Kim SJ, Koo TS.
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 2021, 1179, 122862.
Abstract
Equine metabolism of the selective androgen receptor modulator AC‐262536 in vitro and in urine, plasma and hair following oral administration.
Cutler C, Viljanto M, Taylor P, Habershon‐Butcher J, Muir T, Biddle S, Van Eenoo P.
Drug Test. Anal., 2021, 13, 369–385.
Abstract
Transcriptomic markers of recombinant human erythropoietin micro-dosing in Thoroughbred horses.
Dahlgren AR, Knych HK, Arthur RM, Durbin-Johnson BP, Finno CJ.
Genes (Basel), 2021, 12, 1874.
Abstract
Development of a standardized microflow LC gradient to enable sensitive and long-term detection of synthetic anabolic-androgenic steroids for high-throughput doping controls.
Delcourt V, Garcia P, Pottier I, Mansoibou N, Bache N, Glavieux Y, Chabot B, Perot I, André F, Loup B, Barnabé A, Popot MA, Bailly-Chouriberry L.
Anal. Chem., 2021, 93, 15590-15596.
Abstract
Long-term detection of clodronate in equine plasma by liquid chromatography-tandem mass spectrometry.
Garcia P, Perot I, Loup B, Balssa F, Jaubert M, Delcourt V, Dujardin C, Popot MA, Bailly-Chouriberry L.
Drug Test. Anal., 2021, 13, 1527–1534.
Abstract
Unravelling androgens in sport: Altrenogest shows strong activation of the androgen receptor in a mammalian cell bioassay.
Gillon A, Ho ENM, Chan GHM, Kauff A, Hughes G, Lund RA, Ashley Z, Wan TSM, Heather AK.
Drug Test. Anal., 2021, 13, 523–528.
Abstract
Novel algorithms for comprehensive untargeted detection of doping agents in biological samples.
Guan F, You Y, Fay S, Li X, Robinson MA.
Anal. Chem., 2021, 93, 7746–7753.
Abstract
Tolerance and pharmacokinetics of Galliprant™ administered orally to collies homozygous for MDR1-1Δ.
Heit MC, Mealey KL, King SB.
J. Vet. Pharmacol. Ther., 2021, 44, 705–713.
Abstract
Pharmacokinetics of enflicoxib in dogs: Effects of prandial state and repeated administration.
Homedes J, Salichs M, Solà J, Menargues A, Cendrós JM, Encina G.
J. Vet. Pharmacol. Ther., 2021, 44, 888–901.
Abstract
Stability of ketoprofen methylester in plasma of different species.
Hu SX, Ernst K, Benner CP, Feenstra KL.
Curr. Drug Metab., 2021, 22, 215–223.
Abstract
Detection and longitudinal distribution of GW1516 and its metabolites in equine hair for doping control using liquid chromatography - high-resolution mass spectrometry.
Ishii H, Shibuya M, Leung GNW, Nozawa S, Yamashita S, Yamada M, Kushiro A, Kasashima Y, Okada J, Kawasaki K, Kijima-Suda I.
Rapid Commun. Mass Spectrom., 2021, 35, e9050.
Abstract
Metabolic study of GW1516 in equine urine using liquid chromatography/electrospray ionization Q-Exactive high-resolution mass spectrometer for doping control.
Ishii H, Shibuya M, Leung GNW, Yamashita S, Yamada M, Kushiro A, Kasashima Y, Okada J, Kawasaki K, Kijima-Suda I.
Rapid Commun. Mass Spectrom., 2021, 35, e9028.
Abstract
Metabolism and excretion of the benzodiazepine analog etizolam in the horse.
Johnson E, van Heemst J, Benavides J, Gray B.
Drug Test. Anal., 2021, 13, 583–594.
Abstract
In vitro metabolism of slowly cleared GPR139 agonist TAK-041 using rat, dog, monkey and human hepatocyte models (HepatoPac): correlation with in vivo metabolism.
Kamel A, Bowlin S, Hosea N, Arkilo D, Laurenza A.
Drug Metab. Dispos., 2021, 49, 121–132.
Abstract
Simultaneous analysis of 44 frequently abused corticosteroid drugs using polysaccharide-based chiral column-HRMS approach.
Karakka Kal AK, Karatt TK, Nalakath J, Subhahar MB, Koshy SA, Perwad Z, Muhammed Ajeebsanu MP.
Anal. Sci. Adv., 2021, 2, 427–439.
Abstract
Towards an untargeted mass spectrometric approach for improved screening in equine anti-doping.
Keen B, Cawley A, Fouracre C, Pyke J, Fu S.
Drug Test. Anal., 2021, 13, 1001–1007.
Abstract
Pharmacokinetic analysis of two different doses of simvastatin following oral administration in dogs.
Kim MS, Baek IH.
J. Vet. Pharmacol. Ther., 2021, 44, 333–341.
Abstract
Determination of the route of excretion of robenacoxib (Onsior™) in cats and dogs: A pilot study.
King JN, Jung M.
J. Vet. Pharmacol. Ther., 2021, 44, 411–416.
Abstract
Finding the proverbial needle: Non-targeted screening of synthetic opioids in equine plasma.
Klingberg J, Cawley A, Shimmon R, Fouracre C, Pasin D, Fu S.
Drug Test. Anal., 2021, 13, 977–989.
Abstract
Single‐dose pharmacokinetics of mycophenolic acid following administration of immediate‐release mycophenolate mofetil in healthy beagle dogs.
Klotsman M, Sathyan G, Anderson WH.
J. Vet. Pharmacol. Ther., 2021, 44, 650–656.
Abstract
Pharmacokinetics of transdermal flunixin meglumine and effects on biomarkers of inflammation in horses.
Knych HK, Arthur RM, Gretler SR, McKemie DS, Goldin S, Kass PH.
J. Vet. Pharmacol. Ther., 2021, 44, 745–753.
Abstract
Pharmacokinetics and anti-inflammatory effects of flunixin meglumine as a sole agent and in combination with phenylbutazone in exercised Thoroughbred horses.
Knych HK, Arthur RM, McKemie DS, Baden RW, Seminoff K, Kass PH.
Equine Vet. J., 2021, 53, 102–116.
Abstract
Identification and characterization of the enzymes responsible for the metabolism of the non‐steroidal anti‐inflammatory drugs, flunixin meglumine and phenylbutazone, in horses.
Knych HK, Finno CJ, Baden R, Arthur RM, McKemie DS.
J. Vet. Pharmacol. Ther., 2021, 44, 36–46.
Abstract
Species difference in hydrolysis of an ester-type prodrug of levodopa in human and animal plasma: Different contributions of alpha-1 acid glycoprotein.
Kono K, Nunoya KI, Nakamura Y, Bi J, Mukunoki A, Takeo T, Nakagata N, Hitoshi M, Yamaura Y, Imawaka H, Watanabe H, Maruyama T.
Mol. Pharm., 2021, 18, 1985–1991.
Abstract
Agomelatine: A novel melatonergic antidepressant. Method validation and first exploratory pharmacokinetic study in fasted and fed dogs.
Łebkowska-Wieruszewska B, DELLYZiółkowski H, Sartini I, Lisowski A, Kowalski CJ, Poapolathep A, Giorgi M.
Res. Vet. Sci., 2021, 139, 140–144.
Abstract
Application of a non-target variable data independent workflow (vDIA) for the screening of prohibited substances in doping control testing.
Leung DKK, Wong ASY, Zhou QL, Wan TSM, Ho ENM.
Drug Test. Anal., 2021, 13, 1008–1033.
Abstract
Quantitative determination of AZD3264, a selective Ikb-kinase IKK2 inhibitor, in dog plasma by solvent-induced phase transition extraction coupled with HPLC-MS/MS and its application to pharmacokinetic study in dogs.
Li G, Liang S, Qiao K, Wang C.
J. AOAC Int., 2021, 104, 348–354.
Abstract
A sensitive HPLC-MS/MS method for the detection, resolution and quantitation of cathinone enantiomers in horse blood plasma and urine.
Loganathan D, Yi R, Patel B, Zhang J, Kong N.
Anal. Bioanal. Chem., 2021, 413, 2147–2161.
Abstract
Identification of HIF stabilizer roxadustat and its possible metabolites in Thoroughbred horses for doping control.
Mathew B, Philip M, Perwad Z, Karatt TK, Caveney MR, Subhahar MB, Karakka Kal AK.
Drug Test. Anal., 2021, 13, 1203–1215.
Abstract
Oral pharmacokinetics in beagle dogs of the mitragynine metabolite, 7-hydroxymitragynine.
Maxwell EA, King TI, Kamble SH, Raju KSR, Berthold EC, León F, Hampson A, McMahon LR, McCurdy CR, Sharma A.
Eur. J. Drug Metab. Pharmacokinet., 2021, 46, 459–463.
Abstract
A validated method for the quantification of IOX-2, a potent prolyl hydroxylase inhibitor in equine urine and plasma using liquid chromatography-high-resolution mass spectrometry.
Mikhail E, Siccardi E, Bawazir A, Rajesh A, Prathyush S, Al Wazani DMK, Sabeek M, John T.
Drug Test. Anal., 2021, 13, 1178–1190.
Abstract
Detection of methylphenidate in equine hair using liquid chromatography-high-resolution mass spectrometry.
Moeller BC, Flores L, Clifford A, Alarcio G, Mosburg M, Arthur RM.
Molecules, 2021, 26, 5798.
Abstract
Evaluation of dried blood spots as an alternative sample matrix for equine anti-doping analysis.
Moeller BC, Yang Z.
Drug Test. Anal., 2021, 13, 386–396.
Abstract
Doping detection in animals: A review of analytical methodologies published from 1990 to 2019.
Moreira F, Carmo H, de Pinho PG, de Lourdes Bastos M.
Drug Test. Anal., 2021, 13, 474–504.
Abstract
Plasma and urine pharmacokinetics of two formulations of dexamethasone in greyhound dogs.
Morris T, Paine SW, Zahra P, Li E, Colgan S, Karamatic S.
J. Vet. Pharmacol. Ther., 2021, 44, 689–695.
Abstract
Pharmacodynamics and plasma concentrations of dexmedetomidine with or without vatinoxan as a constant-rate infusion in horses anaesthetized with isoflurane—A pilot study.
Neudeck S, Twele L, Kopp V, Kästner S.
J. Vet. Pharmacol. Ther., 2021, 44, 754–765.
Abstract
Pharmacokinetics of dipyrone in horses: A multi-dose, dose escalation study.
O'Banion MP, Sundman E, Edmonds M, Davis J.
J. Vet. Pharmacol. Ther., 2021, 44, 919–926.
Abstract
Preliminary bioequivalence of an oral integrating film formulation containing meloxicam with a suspension formulation in beagle dogs.
Park JS, Kim S, Lee J, Choi JC, Kim Y, Park CW, Lee S.
J. Vet. Pharmacol. Ther., 2021, 44, 342–348.
Abstract
Characterization of equine liver microsome-generated metabolites of growth hormone secretagogue small molecule ibutamoren.
Philip M, Karakka Kal AK, Subhahar MB, Perwad Z, Karatt TK.
Rapid Commun. Mass Spectrom., 2021, 35, e9201.
Abstract
Metabolic studies of HIF stabilizers IOX2, IOX3, and IOX4 (in vitro) for doping control.
Philip M, Mathew B, Karatt TK, Perwad Z, Subhahar MB, Karakka Kal AK.
Drug Test. Anal., 2021, 13, 794–816.
Abstract
Pharmacodynamics and pharmacokinetics of injectable pimobendan and its metabolite, O-desmethyl-pimobendan, in healthy dogs.
Pichayapaiboon P, Tantisuwat L, Boonpala P, Saengklub N, Boonyarattanasoonthorn T, Khemawoot P, Kijtawornrat A.
Front. Vet. Sci., 2021, 8, 656902.
Abstract
The in vivo metabolism of Furazadrol in greyhounds.
Pranata A, Curtis B, Waller CC, Caldwell K, Zahra PW, Karamatic SL, McLeod MD.
Drug Test. Anal., 2021, 13, 1749–1757.
Abstract
Multidose pharmacokinetics and safety of a modified, compounded theophylline product in dogs.
Reinhart JM, Perkowski C, Lester C, Campos V, Kadotani S, Li Z, McKiernan BC, Fries R.
J. Vet. Pharmacol. Ther., 2021, 44, 902–909.
Abstract
Tiludronic acid can be detected in blood and urine samples from Thoroughbred racehorses over three years after last administration.
Riggs CM, Thompson SL, Wong JKY, So YM, Wan TSM, Robinson P, Stewart BD, Ho ENM.
Equine Vet. J., 2021, 53, 1287–1295.
Abstract
The effect of posaconazole and isavuconazole on the pharmacokinetics of erdafitinib in beagle dogs by UPLC-MS/MS.
Ruan LH, Fan LL, Wang K, Zhang WQ, Wang XJ, Qiu XJ.
Front. Pharmacol., 2021, 12, 749169.
Abstract
Pharmacokinetics and effects on arachidonic acid metabolism of low doses of cannabidiol following oral administration to horses.
Ryan D, McKemie DS, Kass PH, Puschner B, Knych HK.
Drug Test. Anal., 2021, 13, 1305–1317.
Abstract
Pharmacokinetics of acetaminophen after intravenous and oral administration in fasted and fed Labrador retriever dogs.
Sartini I, Łebkowska-Wieruszewska B, Lisowski A, Poapolathep A, Cuniberti B, Giorgi M.
J. Vet. Pharmacol. Ther., 2021, 44, 28–35.
Abstract
Kinetic disposition of diazepam and its metabolites after intravenous administration of diazepam in the horse: Relevance for doping control.
Schenk I, Machnik M, Broussou D, Meuly A, Roques BB, Lallemand E, Düe M, Röttgen H, Lagershausen H, Toutain PL, Thevis M.
J. Vet. Pharmacol. Ther., 2021, 44, 733–744.
Abstract
Pharmacokinetics and pharmacodynamics of intravenous continuous rate infusion and repeated intramuscular administration of dexmedetomidine in standing horses.
Shane SE, Langston VC, Wills RW, Denney WS, Knych H, Fontenot RL, Meyer RE, Natalini CC.
J. Vet. Pharmacol. Ther., 2021, 44, 533–543.
Abstract
Metabolic studies of selective androgen receptor modulators RAD140 and S-23 in horses.
So YM, Wong JKY, Choi TLS, Prabhu A, Stewart B, Farrington AF, Robinson P, Wan TSM, Ho ENM.
Drug Test. Anal., 2021, 13, 318–337.
Abstract
Comparative in vitro metabolism of enflicoxib in dogs, rats, and humans: main metabolites and proposed metabolic pathways.
Solà J, Menargues À, Homedes J, Salichs M, Serafini MT, Encina G.
Drug Metab. Lett., 2021, 14, 206-218.
Abstract
Systemic detectability of dexamethasone and prednisolone after eye drop application in horses.
Stucki M, Voegel CD, Binz TM, Kraemer T, Lavaud A, Voelter K.
Equine Vet. J., 2021, 53, 1250–1256.
Abstract
Pyrotinib in vitro metabolite profiling via rat, dog and human hepatocytes by liquid chromatography-quadrupole/orbitrap mass spectrometry.
Su G, Qin L, Su X, Tao C.
Rapid Commun. Mass Spectrom., 2021, 35, e9195.
Abstract
Detection and identification of ACP‐105 and its metabolites in equine urine using LC/MS/MS after oral administration.
Subhahar MB, Karakka Kal AK, Philip M, Karatt TK, Ibrahimwaseem N., Vazhat RA, Muhammed Ajeebsanu M.P.
Drug Test. Anal., 2021, 13, 299–317.
Abstract
Simulated validation of intron-less transgene detection using DELLY for gene-doping control in horse sports.
Tozaki T, Ohnuma A, Kikuchi K, Ishige T, Kakoi H, Hirota K, Kusano K, Nagata SI.
Anim. Genet., 2021, 52, 759–761.
Abstract
Robustness of digital PCR and real-time PCR against inhibitors in transgene detection for gene doping control in equestrian sports.
Tozaki T, Ohnuma A, Kikuchi M, Ishige T, Kakoi H, Hirota KI, Kusano K, Nagata SI.
Drug Test. Anal., 2021, 13, 1768–1775.
Abstract
Design and storage stability of reference materials for microfluidic quantitative PCR-based equine gene doping tests.
Tozaki T, Ohnuma A, Kikuchi M, Ishige T, Kakoi H, Hirota KI, Kusano K, Nagata SI.
J. Equine Sci., 2021, 32, 125–134.
Abstract
Comprehensive characterization of the PPAR-δ agonist GW501516 for horse doping control analysis.
Trevisiol S, Moulard Y, Delcourt V, Jaubert M, Boyer S, Tendon S, Haryouli H, Taleb W, Caroff M, Chabot B, Drif L, André F, Garcia P, Loup B, Barnabé A, Popot MA, Bailly-Chouriberry L.
Drug Test. Anal., 2021, 13, 1191–1202.
Abstract
Pharmacokinetics and pharmacodynamics of intravenous and oral apixaban in horses.
Wallace GE, McKaba VF, Reinhart JM, Li Z, Austin S, Fries RC.
J. Vet. Pharmacol. Ther., 2021, 44, 724–732.
Abstract
The pharmacokinetic effect of itraconazole and voriconazole on ripretinib in beagle dogs by UPLC-MS/MS technique.
Wang HJ, Zhou CY, Su YD, Gou KF, Geng XN, Qiu XJ.
Drug Des. Devel. Ther., 2021, 15, 4865–4873.
Abstract
Development of an UPLC-MS/MS method for the quantitative analysis of upadacitinib in beagle dog plasma and pharmacokinetics study.
Wang MJ, Zhao YH, Fan C, Wang YJ, Wang XQ, Qiu XJ, Shen RL.
Drug Des. Devel. Ther., 2021, 15, 4167–4175.
Abstract
Concentration profiles and safety of topically applied betulinic acid and NVX‐207 in eight healthy horses—A randomized, blinded, placebo‐controlled, crossover pilot study.
Weber LA, Puff C, Kalbitz J, Kietzmann M, Feige K, Bosse K, Rohn K, Cavalleri JMV.
J. Vet. Pharmacol. Ther., 2021, 44, 47–57.
Abstract
Effect of sijunzi pills on pharmacokinetics of omeprazole in beagle dogs by HPLC-UV: A herb-drug interaction study.
Xia HL, Zhao XJ, Zhang YJ, Su XH, Sun B, Qiu XJ.
Evid. Based Complement. Alternat. Med., 2021, 4181196.
Abstract
Quantitation of apremilast in beagle dogs plasma by UPLC-MS-MS and iIts application to pharmacokinetic studies.
Xiong W, Wang L, Zhang H, Tao X, Jiang X, Liu Z, Zhao J, Xu W.
J. Anal. Methods Chem., 2021, 8881076.
Abstract
Simultaneous determination of naproxen and esomeprazole in beagle dog plasma by supercritical fluid chromatography-tandem mass spectrometry coupled with evaporation-free liquid-liquid extraction.
Yang Y, Li X, Zhou Q, Sun L, Zhang T.
J. Pharm. Biomed. Anal., 2021, 193, 113668.
Abstract
Pharmacokinetic profiles of metamizole metabolites after intramuscular and intravenous administration in healthy Arabian horses.
Yılmaz İ, Maraş Z, Uğur Y, Özgür ME, Durmaz M, Ulusoy Hİ, Erdoğan S.
J. Vet. Pharmacol. Ther., 2021, 44, 927–936.
Abstract
Use of high resolution/accurate mass full scan/data-dependent acquisition for targeted/non-targeted screening in equine doping control.
You Y, Proctor RM, Guo K, Li X, Xue E, Guan F, Robinson MA.
Anal. Methods, 2021, 13, 1565–l1575.
Abstract
Absorption, metabolism and excretion of pictilisib, a potent pan-class I phosphatidylinositol-3-kinase (PI3K) inhibitor, in rats, dogs, and humans.
Yue Q, Khojasteh SC, Cho S, Ma S, Mulder T, Chen J, Pang J, Ding X, Deese A, Pellet J, Siebers N, Joas L, Salphati L, Ware J.
Xenobiotica, 2021, 51, 796–810.
Abstract
Pharmacokinetics of S-epacadostat, an indoleamine 2,3-dioxygenase 1 inhibitor, in dog plasma and identification of its metabolites in vivo and in vitro.
Zhang Y, Li X, Sun Y, Liu X, Wang W, Tian J.
Biomed. Chromatogr., 2021, 35, e5226.
Abstract
Simultaneous determination of loratadine and its metabolite desloratadine in beagle plasma by LC-MS/MS and application for pharmacokinetics study of loratadine tablets and omeprazole‑induced drug-drug interaction.
Zhang Y, Zhang J, Xu Q, Wang Y, Wu W, Wang W, Li X, Zhang T.
Drug Des. Devel. Ther., 2021, 15, 5109–5122.
Abstract
