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2021 Articles

Accepted articles

Pharmacokinetics of paracetamol in the Thoroughbred horse following an oral multi-dose administration.
Pesko B, Habershon-Butcher J, Muir T, Gray B, Taylor P, Fenwick S, Hincks P, Scarth J, Paine S.
J. Vet. Pharmacol. Ther., DOI 10.1111/jvp.13024.
Abstract

LC-HRMS/MS study of the prodrug ciclesonide and its active metabolite desisobutyryl-ciclesonide in plasma after an inhalative administration to horses for doping control purposes.
Trevisiol S, Moulard Y, Kaabia Z, Delcourt V, Loup B, Garcia P, Boyer S, Dauriac K, Groseille G, Rouger S, Narbe R, Popot MA, Bailly-Chouriberry L.
Drug Test. Anal., DOI 10.1002/dta.3174.
Abstract

Low-copy transgene detection using nested digital PCR for gene doping control.
Tozaki T, Ohnuma A, Hamilton NA, Kikuchi M, Ishige T, Kakoi H, Hirota KI, Kusano K, Nagata SI.
Drug Test. Anal., DOI 10.1002/dta.3173.
Abstract

Comprehensive metabolic study of IOX4 in equine urine and plasma using liquid chromatography/electrospray ionization Q Exactive high-resolution mass spectrometer for the purpose of doping control.
Ishii H, Shibuya M, So YM, Wong JKY, Ho ENM, Kusano K, Sone Y, Kamiya T, Wakuno A, Ito H, Miyata K, Yamada M, Leung GN.
Drug Test. Anal., DOI 10.1002/dta.3172.
Abstract

The equine metabolism of the catechol-O-methyltransferase enzyme inhibitor nitecapone.
Stanley S, Deng D, Van den Berg K, Foo HC.
Drug Test. Anal., DOI 10.1002/dta.3163.
Abstract

Pyrotinib in vitro metabolite profiling via rat, dog and human hepatocytes by liquid chromatography-quadrupole/orbitrap mass spectrometry.
Su G, Qin L, Su X, Tao C.
Rapid Commun. Mass Spectrom., DOI 10.1002/rcm.9195.
Abstract

Plasma and urine pharmacokinetics of hydroxyzine and cetirizine following repeated oral administrations to exercised horses.
Paine SW, Aldurdunji M, Garth-Greeves A, Muir T, Hincks PR.
J. Vet. Pharmacol. Ther., DOI 10.1111/jvp.13010.
Abstract

Pharmacokinetic profiles of metamizole metabolites after intramuscular and intravenous administration in healthy Arabian horses.
Yılmaz İ, Maraş Z, Uğur Y, Özgür ME, Durmaz M, Ulusoy Hİ, Erdoğan S.
J. Vet. Pharmacol. Ther., DOI 10.1111/jvp.13003.
Abstract

Sequence determination of phosphorothioated oligonucleotides using MALDI-TOF mass spectrometry for controlling gene doping in equestrian sports.
Tozaki T, Kwak HG, Nakamura K, Takasu M, Ishii H, Ohnuma A, Kikuchi M, Ishige T, Kakoi H, Hirota KI, Kusano K, Hirata M, Nirasawa T, Nagata SI.
Drug Test. Anal., DOI 10.1002/dta.3154.
Abstract

Pharmacokinetics of S-epacadostat, an indoleamine 2,3-dioxygenase 1 inhibitor, in dog plasma and identification of its metabolites in vivo and in vitro.
Zhang Y, Li X, Sun Y, Liu X, Wang W, Tian J.
Biomed. Chromatogr., DOI 10.1002/bmc.5226.
Abstract

Simulated validation of intron-less transgene detection using DELLY for gene-doping control in horse sports.
Tozaki T, Ohnuma A, Kikuchi K, Ishige T, Kakoi H, Hirota K, Kusano K, Nagata S.
Anim. Genet., DOI 10.1111/age.13127.
Abstract

Detection and confirmation of zilpaterol in equine hair using liquid chromatography-mass spectrometry.
Moeller BC, Clifford A, Emery RT, Alarcio G, Favro G, Arthur RM.
Drug Test. Anal., DOI 10.1002/dta.3138.
Abstract

Bioanalysis of niclosamide in plasma using liquid chromatography-tandem mass and application to pharmacokinetics in rats and dogs.
Choi HI, Kim T, Lee SW, Woo Kim J, Ju Noh Y, Kim GY, Jin Park H, Chae YJ, Lee KR, Kim SJ, Koo TS.
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., DOI 10.1016/j.jchromb.2021.122862.
Abstract

Screening for gene doping transgenes in horses via the use of massively parallel sequencing.
Maniego J, Pesko B, Habershon-Butcher J, Huggett J, Taylor P, Scarth J, Ryder E.
Gene Ther., DOI 10.1038/s41434-021-00279-1.
Abstract

Pharmacokinetics of dipyrone in horses: A multi-dose, dose escalation study.
O'Banion MP, Sundman E, Edmonds M, Davis J.
J. Vet. Pharmacol. Ther., DOI 10.1111/jvp.12996.
Abstract

In vitro metabolism of the REV-ERB agonist SR-9009 and subsequent detection of metabolites in associated routine equine plasma and urine doping control samples.
Cutler C, White D, Viljanto M.
Drug Test. Anal., DOI 10.1002/dta.3124.
Abstract

Multidose pharmacokinetics and safety of a modified, compounded theophylline product in dogs.
Reinhart JM, Perkowski C, Lester C, Campos V, Kadotani S, Li Z, McKiernan BC, Fries R.
J. Vet. Pharmacol. Ther., DOI 10.1111/jvp.12997.
Abstract

Pharmacokinetics of enflicoxib in dogs: Effects of prandial state and repeated administration.
Homedes J, Salichs M, Solà J, Menargues A, Cendrós JM, Encina G.
J. Vet. Pharmacol. Ther., DOI 10.1111/jvp.12995.
Abstract

Control of gene doping in human and horse sports.
Tozaki T, Hamilton NA.
Gene Ther., DOI 10.1038/s41434-021-00267-5.
Abstract

Establishment of a post-race biomarkers database and application of pathway analysis to identify potential biomarkers in post-race equine plasma.
Ohnuma K, Uchida T, Leung GN, Ueda T, Obara T, Ishii H.
Drug Test. Anal., DOI 10.1002/dta.3041.
Abstract

A quick approach for medetomidine enantiomers determination in dog plasma by chiral LC-MS/MS and application to a pharmacokinetic study.
Bardhi A, Zaghini A, Levionnois O, Barbarossa A.
Drug Test. Anal., DOI 10.1002/dta.3015.
Abstract

The pharmacokinetics of a fentanyl matrix patch applied at three different anatomical locations in horses.
Skrzypczak H, Reed R, Brainard B, Sakai D, Barletta M, Quandt J, Smyth C, Ruch M, Kynch H.
Equine Vet. J., DOI 10.1111/evj.13424.
Abstract

Systemic detectability of dexamethasone and prednisolone after eye drop application in horses.
Stucki M, Voegel CD, Binz TM, Kraemer T, Lavaud A, Voelter K.
Equine Vet. J., DOI 10.1111/evj.13418.
Abstract

Published articles

Plasma levels of a methadone constant rate infusion and their corresponding effects on thermal and mechanical nociceptive thresholds in dogs.
Amon T, Kästner SBR, Kietzmann M, Tünsmeyer J.
BMC Vet. Res., 2021, 17, 35.
Abstract

The effect of serial administration of bicarbonate on plasma total CO2 concentrations in horses.
Bailey SR, Forbes G, Selvadurai N, McLarney K, Jones S, Steel CM.
Drug Test. Anal., 2021, 13, 397–403.
Abstract

Investigation of equine in vivo and in vitro derived metabolites of the selective androgen receptor modulator (SARM) ACP-105 for improved doping control.
Broberg MN, Knych H, Bondesson U, Pettersson C, Stanley S, Thevis M, Hedeland M.
Metabolites, 2021, 11, 85.
Abstract

Quantification of 17 endogenous and exogenous steroidal hormones in equine and bovine blood for doping control with UHPLC-MS/MS.
Caprioli G, Genangeli M, Mustafa AM, Petrelli R, Ricciutelli M, Sagratini G, Sartori S, Laus F, Vittori S, Cortese M.
Pharmaceuticals (Basel), 2021, 14, 393.
Abstract

A duplex qPCR assay for human erythropoietin (EPO) transgene to control gene doping in horses.
Cheung HW, Wong KS, Lin VYC, Wan TSM, Ho ENM.
Drug Test. Anal., 2021, 13, 113–121.
Abstract

Label-free proteomics for discovering biomarker candidates of RAD140 administration to castrated horses.
Cheung HW, Wong KS, To NS, Bond AJ, Farrington AF, Prabhu A, Curl P, Wan TSM, Ho ENM.
Drug Test. Anal., 2021, 13, 1034–1047.
Abstract

Equine metabolism of the selective androgen receptor modulator AC‐262536 in vitro and in urine, plasma and hair following oral administration.
Cutler C, Viljanto M, Taylor P, Habershon‐Butcher J, Muir T, Biddle S, Van Eenoo P.
Drug Test. Anal., 2021, 13, 369–385.
Abstract

Long-term detection of clodronate in equine plasma by liquid chromatography-tandem mass spectrometry.
Garcia P, Perot I, Loup B, Balssa F, Jaubert M, Delcourt V, Dujardin C, Popot MA, Bailly-Chouriberry L.
Drug Test. Anal., 2021, 13, 1527–1534.
Abstract

Unravelling androgens in sport: Altrenogest shows strong activation of the androgen receptor in a mammalian cell bioassay.
Gillon A, Ho ENM, Chan GHM, Kauff A, Hughes G, Lund RA, Ashley Z, Wan TSM, Heather AK.
Drug Test. Anal., 2021, 13, 523–528.
Abstract

Novel algorithms for comprehensive untargeted detection of doping agents in biological samples.
Guan F, You Y, Fay S, Li X, Robinson MA.
Anal. Chem., 2021, 93, 7746–7753.
Abstract

Tolerance and pharmacokinetics of Galliprant™ administered orally to collies homozygous for MDR1-1Δ.
Heit MC, Mealey KL, King SB.
J. Vet. Pharmacol. Ther., 2021, 44, 705–713.
Abstract

Stability of ketoprofen methylester in plasma of different species.
Hu SX, Ernst K, Benner CP, Feenstra KL.
Curr. Drug Metab., 2021, 22, 215–223.
Abstract

Detection and longitudinal distribution of GW1516 and its metabolites in equine hair for doping control using liquid chromatography - high-resolution mass spectrometry.
Ishii H, Shibuya M, Leung GNW, Nozawa S, Yamashita S, Yamada M, Kushiro A, Kasashima Y, Okada J, Kawasaki K, Kijima-Suda I.
Rapid Commun. Mass Spectrom., 2021, 35, e9050.
Abstract

Metabolic study of GW1516 in equine urine using liquid chromatography/electrospray ionization Q-Exactive high-resolution mass spectrometer for doping control.
Ishii H, Shibuya M, Leung GNW, Yamashita S, Yamada M, Kushiro A, Kasashima Y, Okada J, Kawasaki K, Kijima-Suda I.
Rapid Commun. Mass Spectrom., 2021, 35, e9028.
Abstract

Metabolism and excretion of the benzodiazepine analog etizolam in the horse.
Johnson E, van Heemst J, Benavides J, Gray B.
Drug Test. Anal., 2021, 13, 583–594.
Abstract

In vitro metabolism of slowly cleared GPR139 agonist TAK-041 using rat, dog, monkey and human hepatocyte models (HepatoPac): correlation with in vivo metabolism.
Kamel A, Bowlin S, Hosea N, Arkilo D, Laurenza A.
Drug Metab. Dispos., 2021, 49, 121–132.
Abstract

Towards an untargeted mass spectrometric approach for improved screening in equine anti-doping.
Keen B, Cawley A, Fouracre C, Pyke J, Fu S.
Drug Test. Anal., 2021, 13, 1001–1007.
Abstract

Pharmacokinetic analysis of two different doses of simvastatin following oral administration in dogs.
Kim MS, Baek IH.
J. Vet. Pharmacol. Ther., 2021, 44, 333–341.
Abstract

Determination of the route of excretion of robenacoxib (Onsior™) in cats and dogs: A pilot study.
King JN, Jung M.
J. Vet. Pharmacol. Ther., 2021, 44, 411–416.
Abstract

Finding the proverbial needle: Non-targeted screening of synthetic opioids in equine plasma.
Klingberg J, Cawley A, Shimmon R, Fouracre C, Pasin D, Fu S.
Drug Test. Anal., 2021, 13, 977–989.
Abstract

Single‐dose pharmacokinetics of mycophenolic acid following administration of immediate‐release mycophenolate mofetil in healthy beagle dogs.
Klotsman M, Sathyan G, Anderson WH.
J. Vet. Pharmacol. Ther., 2021, 44, 650–656.
Abstract

Pharmacokinetics of transdermal flunixin meglumine and effects on biomarkers of inflammation in horses.
Knych HK, Arthur RM, Gretler SR, McKemie DS, Goldin S, Kass PH.
J. Vet. Pharmacol. Ther., 2021, 44, 745–753.
Abstract

Pharmacokinetics and anti-inflammatory effects of flunixin meglumine as a sole agent and in combination with phenylbutazone in exercised Thoroughbred horses.
Knych HK, Arthur RM, McKemie DS, Baden RW, Seminoff K, Kass PH.
Equine Vet. J., 2021, 53, 102–116.
Abstract

Identification and characterization of the enzymes responsible for the metabolism of the non‐steroidal anti‐inflammatory drugs, flunixin meglumine and phenylbutazone, in horses.
Knych HK, Finno CJ, Baden R, Arthur RM, McKemie DS.
J. Vet. Pharmacol. Ther., 2021, 44, 36–46.
Abstract

Species difference in hydrolysis of an ester-type prodrug of levodopa in human and animal plasma: Different contributions of alpha-1 acid glycoprotein.
Kono K, Nunoya KI, Nakamura Y, Bi J, Mukunoki A, Takeo T, Nakagata N, Hitoshi M, Yamaura Y, Imawaka H, Watanabe H, Maruyama T.
Mol. Pharm., 2021, 18, 1985–1991.
Abstract

Agomelatine: A novel melatonergic antidepressant. Method validation and first exploratory pharmacokinetic study in fasted and fed dogs.
Łebkowska-Wieruszewska B, DELLYZiółkowski H, Sartini I, Lisowski A, Kowalski CJ, Poapolathep A, Giorgi M.
Res. Vet. Sci., 2021, 139, 140–144.
Abstract

Application of a non-target variable data independent workflow (vDIA) for the screening of prohibited substances in doping control testing.
Leung DKK, Wong ASY, Zhou QL, Wan TSM, Ho ENM.
Drug Test. Anal., 2021, 13, 1008–1033.
Abstract

Quantitative determination of AZD3264, a selective Ikb-kinase IKK2 inhibitor, in dog plasma by solvent-induced phase transition extraction coupled with HPLC-MS/MS and its application to pharmacokinetic study in dogs.
Li G, Liang S, Qiao K, Wang C.
J. AOAC Int., 2021, 104, 348–354.
Abstract

A sensitive HPLC-MS/MS method for the detection, resolution and quantitation of cathinone enantiomers in horse blood plasma and urine.
Loganathan D, Yi R, Patel B, Zhang J, Kong N.
Anal. Bioanal. Chem., 2021, 413, 2147–2161.
Abstract

Identification of HIF stabilizer roxadustat and its possible metabolites in Thoroughbred horses for doping control.
Mathew B, Philip M, Perwad Z, Karatt TK, Caveney MR, Subhahar MB, Karakka Kal AK.
Drug Test. Anal., 2021, 13, 1203–1215.
Abstract

Oral pharmacokinetics in beagle dogs of the mitragynine metabolite, 7-hydroxymitragynine.
Maxwell EA, King TI, Kamble SH, Raju KSR, Berthold EC, León F, Hampson A, McMahon LR, McCurdy CR, Sharma A.
Eur. J. Drug Metab. Pharmacokinet., 2021, 46, 459–463.
Abstract

A validated method for the quantification of IOX-2, a potent prolyl hydroxylase inhibitor in equine urine and plasma using liquid chromatography-high-resolution mass spectrometry.
Mikhail E, Siccardi E, Bawazir A, Rajesh A, Prathyush S, Al Wazani DMK, Sabeek M, John T.
Drug Test. Anal., 2021, 13, 1178–1190.
Abstract

Detection of methylphenidate in equine hair using liquid chromatography-high-resolution mass spectrometry.
Moeller BC, Flores L, Clifford A, Alarcio G, Mosburg M, Arthur RM.
Molecules, 2021, 26, 5798.
Abstract

Evaluation of dried blood spots as an alternative sample matrix for equine anti-doping analysis.
Moeller BC, Yang Z.
Drug Test. Anal., 2021, 13, 386–396.
Abstract

Doping detection in animals: A review of analytical methodologies published from 1990 to 2019.
Moreira F, Carmo H, de Pinho PG, de Lourdes Bastos M.
Drug Test. Anal., 2021, 13, 474–504.
Abstract

Plasma and urine pharmacokinetics of two formulations of dexamethasone in greyhound dogs.
Morris T, Paine SW, Zahra P, Li E, Colgan S, Karamatic S.
J. Vet. Pharmacol. Ther., 2021, 44, 689–695.
Abstract

Pharmacodynamics and plasma concentrations of dexmedetomidine with or without vatinoxan as a constant-rate infusion in horses anaesthetized with isoflurane—A pilot study.
Neudeck S, Twele L, Kopp V, Kästner S.
J. Vet. Pharmacol. Ther., 2021, 44, 754–765.
Abstract

Preliminary bioequivalence of an oral integrating film formulation containing meloxicam with a suspension formulation in beagle dogs.
Park JS, Kim S, Lee J, Choi JC, Kim Y, Park CW, Lee S.
J. Vet. Pharmacol. Ther., 2021, 44, 342–348.
Abstract

Metabolic studies of HIF stabilizers IOX2, IOX3, and IOX4 (in vitro) for doping control.
Philip M, Mathew B, Karatt TK, Perwad Z, Subhahar MB, Karakka Kal AK.
Drug Test. Anal., 2021, 13, 794–816.
Abstract

Pharmacodynamics and pharmacokinetics of injectable pimobendan and its metabolite, O-desmethyl-pimobendan, in healthy dogs.
Pichayapaiboon P, Tantisuwat L, Boonpala P, Saengklub N, Boonyarattanasoonthorn T, Khemawoot P, Kijtawornrat A.
Front. Vet. Sci., 2021, 8, 656902.
Abstract

The in vivo metabolism of Furazadrol in greyhounds.
Pranata A, Curtis B, Waller CC, Caldwell K, Zahra PW, Karamatic SL, McLeod MD.
Drug Test. Anal., 2021, 13, 1749–1757.
Abstract

Tiludronic acid can be detected in blood and urine samples from Thoroughbred racehorses over three years after last administration.
Riggs CM, Thompson SL, Wong JKY, So YM, Wan TSM, Robinson P, Stewart BD, Ho ENM.
Equine Vet. J., 2021, 53, 1287–1295.
Abstract

Pharmacokinetics and effects on arachidonic acid metabolism of low doses of cannabidiol following oral administration to horses.
Ryan D, McKemie DS, Kass PH, Puschner B, Knych HK.
Drug Test. Anal., 2021, 13, 1305–1317.
Abstract

Pharmacokinetics of acetaminophen after intravenous and oral administration in fasted and fed Labrador retriever dogs.
Sartini I, Łebkowska-Wieruszewska B, Lisowski A, Poapolathep A, Cuniberti B, Giorgi M.
J. Vet. Pharmacol. Ther., 2021, 44, 28–35.
Abstract

Kinetic disposition of diazepam and its metabolites after intravenous administration of diazepam in the horse: Relevance for doping control.
Schenk I, Machnik M, Broussou D, Meuly A, Roques BB, Lallemand E, Düe M, Röttgen H, Lagershausen H, Toutain PL, Thevis M.
J. Vet. Pharmacol. Ther., 2021, 44, 733–744.
Abstract

Pharmacokinetics and pharmacodynamics of intravenous continuous rate infusion and repeated intramuscular administration of dexmedetomidine in standing horses.
Shane SE, Langston VC, Wills RW, Denney WS, Knych H, Fontenot RL, Meyer RE, Natalini CC.
J. Vet. Pharmacol. Ther., 2021, 44, 533–543.
Abstract

Metabolic studies of selective androgen receptor modulators RAD140 and S-23 in horses.
So YM, Wong JKY, Choi TLS, Prabhu A, Stewart B, Farrington AF, Robinson P, Wan TSM, Ho ENM.
Drug Test. Anal., 2021, 13, 318–337.
Abstract

Detection and identification of ACP‐105 and its metabolites in equine urine using LC/MS/MS after oral administration.
Subhahar MB, Karakka Kal AK, Philip M, Karatt TK, Ibrahimwaseem N., Vazhat RA, Muhammed Ajeebsanu M.P.
Drug Test. Anal., 2021, 13, 299–317.
Abstract

Robustness of digital PCR and real-time PCR against inhibitors in transgene detection for gene doping control in equestrian sports.
Tozaki T, Ohnuma A, Kikuchi M, Ishige T, Kakoi H, Hirota KI, Kusano K, Nagata SI.
Drug Test. Anal., 2021, 13, 1768–1775.
Abstract

Comprehensive characterization of the PPAR-δ agonist GW501516 for horse doping control analysis.
Trevisiol S, Moulard Y, Delcourt V, Jaubert M, Boyer S, Tendon S, Haryouli H, Taleb W, Caroff M, Chabot B, Drif L, André F, Garcia P, Loup B, Barnabé A, Popot MA, Bailly-Chouriberry L.
Drug Test. Anal., 2021, 13, 1191–1202.
Abstract

Pharmacokinetics and pharmacodynamics of intravenous and oral apixaban in horses.
Wallace GE, McKaba VF, Reinhart JM, Li Z, Austin S, Fries RC.
J. Vet. Pharmacol. Ther., 2021, 44, 724–732.
Abstract

Development of an UPLC-MS/MS method for the quantitative analysis of upadacitinib in beagle dog plasma and pharmacokinetics study.
Wang MJ, Zhao YH, Fan C, Wang YJ, Wang XQ, Qiu XJ, Shen RL.
Drug Des. Devel. Ther., 2021, 15, 4167–4175.
Abstract

Concentration profiles and safety of topically applied betulinic acid and NVX‐207 in eight healthy horses—A randomized, blinded, placebo‐controlled, crossover pilot study.
Weber LA, Puff C, Kalbitz J, Kietzmann M, Feige K, Bosse K, Rohn K, Cavalleri JMV.
J. Vet. Pharmacol. Ther., 2021, 44, 47–57.
Abstract

Quantitation of apremilast in beagle dogs plasma by UPLC-MS-MS and iIts application to pharmacokinetic studies.
Xiong W, Wang L, Zhang H, Tao X, Jiang X, Liu Z, Zhao J, Xu W.
J. Anal. Methods Chem., 2021, 8881076.
Abstract

Simultaneous determination of naproxen and esomeprazole in beagle dog plasma by supercritical fluid chromatography-tandem mass spectrometry coupled with evaporation-free liquid-liquid extraction.
Yang Y, Li X, Zhou Q, Sun L, Zhang T.
J. Pharm. Biomed. Anal., 2021, 193, 113668.
Abstract

Use of high resolution/accurate mass full scan/data-dependent acquisition for targeted/non-targeted screening in equine doping control.
You Y, Proctor RM, Guo K, Li X, Xue E, Guan F, Robinson MA.
Anal. Methods, 2021, 13, 1565–l1575.
Abstract

Absorption, metabolism and excretion of pictilisib, a potent pan-class I phosphatidylinositol-3-kinase (PI3K) inhibitor, in rats, dogs, and humans.
Yue Q, Khojasteh SC, Cho S, Ma S, Mulder T, Chen J, Pang J, Ding X, Deese A, Pellet J, Siebers N, Joas L, Salphati L, Ware J.
Xenobiotica, 2021, 51, 796–810.
Abstract